ID Q9D506_MOUSE Unreviewed; 307 AA.
AC Q9D506;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 152.
DE SubName: Full=Predicted gene 3404 {ECO:0000313|Ensembl:ENSMUSP00000106226.2};
GN Name=Gm3404 {ECO:0000313|Ensembl:ENSMUSP00000106226.2,
GN ECO:0000313|MGI:MGI:3781582};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAB30045.1};
RN [1] {ECO:0000313|EMBL:BAB30045.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB30045.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAB30045.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAB30045.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB30045.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAB30045.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAB30045.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB30045.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAB30045.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:BAB30045.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB30045.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAB30045.1};
RA Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T.,
RA Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T.,
RA Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F., Imotani K.,
RA Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y.,
RA Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A.,
RA Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C.,
RA Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K.,
RA Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M.,
RA Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T.,
RA Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y.;
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:BAB30045.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB30045.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAB30045.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [6] {ECO:0000313|EMBL:BAB30045.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB30045.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAB30045.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [7] {ECO:0000313|EMBL:BAB30045.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB30045.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAB30045.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [8] {ECO:0000313|EMBL:BAB30045.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB30045.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAB30045.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
RN [9] {ECO:0000313|Ensembl:ENSMUSP00000106226.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000106226.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [10] {ECO:0000313|Ensembl:ENSMUSP00000106226.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000106226.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AK015946; BAB30045.1; -; mRNA.
DR RefSeq; NP_001230038.1; NM_001243109.1.
DR PaxDb; 10090-ENSMUSP00000106226; -.
DR Ensembl; ENSMUST00000110596.2; ENSMUSP00000106226.2; ENSMUSG00000079091.2.
DR GeneID; 100041554; -.
DR KEGG; mmu:100041554; -.
DR UCSC; uc009anh.1; mouse.
DR AGR; MGI:3781582; -.
DR MGI; MGI:3781582; Gm3404.
DR VEuPathDB; HostDB:ENSMUSG00000079091; -.
DR eggNOG; KOG3629; Eukaryota.
DR GeneTree; ENSGT00940000155423; -.
DR HOGENOM; CLU_882671_0_0_1; -.
DR OrthoDB; 5085327at2759; -.
DR TreeFam; TF339069; -.
DR BioGRID-ORCS; 100041554; 5 hits in 33 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 5.
DR Bgee; ENSMUSG00000079091; Expressed in spermatid and 3 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR PANTHER; PTHR46793:SF1; 1700018F24RIK PROTEIN-RELATED; 1.
DR PANTHER; PTHR46793; 1700018F24RIK PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 2: Evidence at transcript level;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00135};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 58..181
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT REGION 191..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 307 AA; 34926 MW; 88BC689735921F3E CRC64;
MFSCFQGSRG SGHKKAKSGF LVRFWRRLIR PLTHFRHASH SEPKVCSQNE QEPDSLPKRP
QFNYDSQEYV VQMIHYIPAA IQKRDHICIT IFLGVYRTYA STWEVLDLLM RTYASFRPDC
IKDQQTKRAI FRFLFGWFKK YPQDFYESPD LAVVRQFIDY VKRNVPSSDV DRARELLSVL
EDQEAIELQI EQAPEPSEQD ASGRQETLAP RPASETEPQG DKQPREDPEL VKGAVLDPFE
PKATIELPPS LHQAVPTSDG TLSPVDVTAD EATGVAADVS PARQLFVSYT VQLGTPDFVI
PLPEVDI
//