ID Q9EHG0_9HIV1 Unreviewed; 328 AA.
AC Q9EHG0;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:AAF90385.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AAF90385.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAF90385.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAF90385.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=068B01 {ECO:0000313|EMBL:AAF90385.1};
RX PubMed=10952598; DOI=10.1128/AAC.44.9.2475-2484.2000;
RA Bacheler L.T., Anton E.D., Kudish P., Baker D., Bunville J., Krakowski K.,
RA Bolling L., Aujay M., Wang X.V., Ellis D., Becker M.F., Lasut A.L.,
RA George H.J., Spalding D.R., Hollis G., Abremski K.;
RT "Human immunodeficiency virus type 1 mutations selected in patients failing
RT efavirenz combination therapy.";
RL Antimicrob. Agents Chemother. 44:2475-2484(2000).
RN [2] {ECO:0000313|EMBL:AAF90385.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=068B01 {ECO:0000313|EMBL:AAF90385.1};
RA Abremski K.E., Bacheler L.T., Li J.;
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the retroviral Pol polyprotein family.
CC {ECO:0000256|RuleBase:RU004064}.
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DR EMBL; AY001514; AAF90385.1; -; Genomic_RNA.
DR MEROPS; A02.001; -.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR CDD; cd05482; HIV_retropepsin_like; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001995; Peptidase_A2_cat.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR034170; Retropepsin-like_cat_dom.
DR InterPro; IPR018061; Retropepsins.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00077; RVP; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50175; ASP_PROT_RETROV; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750,
KW ECO:0000256|RuleBase:RU004064};
KW DNA integration {ECO:0000256|ARBA:ARBA00023195};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004064};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|RuleBase:RU004064};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023195};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 20..89
FT /note="Peptidase A2"
FT /evidence="ECO:0000259|PROSITE:PS50175"
FT DOMAIN 143..328
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAF90385.1"
FT NON_TER 328
FT /evidence="ECO:0000313|EMBL:AAF90385.1"
SQ SEQUENCE 328 AA; 37474 MW; CF90119E91975E3A CRC64;
PQITLWQRPL VTIKVEGQLK EALLDTGADD TVLEDIKLSG KWKPKMIGGI GGFIKVRQYD
QVPIEICGHK AIGTVLVGPT PVNIIGRNLL TQLGCTLNFP ISPIETVPVK LKPGMDGPKV
KQWPLTEEKI KALTEICTEM EKEGKISKIG PENPYNTPIF AIKKKNSDRW RKLVDFRELN
KRTQDFWEVQ LGIPHPAGLK KNKSVTVLDV GDAYFSVPLD KEFRKYTAFT IPSTNNETPG
IRYQYNVLPQ GWKGSPAIFQ SSMTKILEPF RKQNPEVVIY QYMDDLYVGS DLEIEQHRTK
IEKLREHLLR WGFTTPDQKH QKEPPFLW
//
