ID Q9F2L2_STRCO Unreviewed; 245 AA.
AC Q9F2L2;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE SubName: Full=TetR family transcriptional regulatory protein {ECO:0000313|EMBL:CAC10307.1};
GN OrderedLocusNames=SCO3769 {ECO:0000313|EMBL:CAC10307.1};
GN ORFNames=SCH63.16c {ECO:0000313|EMBL:CAC10307.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAC10307.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAC10307.1, ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145
RC {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
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DR EMBL; AL939117; CAC10307.1; -; Genomic_DNA.
DR RefSeq; NP_627959.1; NC_003888.3.
DR RefSeq; WP_011029222.1; NZ_VNID01000003.1.
DR AlphaFoldDB; Q9F2L2; -.
DR STRING; 100226.gene:17761393; -.
DR PaxDb; 100226-SCO3769; -.
DR PATRIC; fig|100226.15.peg.3828; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_069356_17_0_11; -.
DR InParanoid; Q9F2L2; -.
DR OrthoDB; 9795011at2; -.
DR PhylomeDB; Q9F2L2; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR InterPro; IPR049445; TetR_SbtR-like_C.
DR PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR PANTHER; PTHR30055:SF246; POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY); 1.
DR Pfam; PF21597; TetR_C_43; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW Reference proteome {ECO:0000313|Proteomes:UP000001973};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 17..76
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 39..58
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 245 AA; 25891 MW; 37C8A1F7E0ED2BA3 CRC64;
MTVGARDGAP RQRRDARRNR ELLLEAAHEV FTEQGLDAAL DVIARRAGVG NATLYRHFPT
RAALVDAVFR DSLTGTMDAG ERARKAPDAW AGLTGYLEVV FGALAADRGS NDLMTTHLRG
VDSLEAVHEH NRRTVDTLLT RLRDEGTVRA DVTTEDVLFG LAALGRAVPA LTAATAATAA
AASAPAAETA PDAWRRPLAL FLGGLRAAPA AASLPAPALT AAELGEVLRE LGPHRTRAGD
REPRA
//
