ID Q9FC52_STRCO Unreviewed; 923 AA.
AC Q9FC52;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 135.
DE SubName: Full=Transcriptional regulatory protein {ECO:0000313|EMBL:CAC04240.1};
GN OrderedLocusNames=SCO7134 {ECO:0000313|EMBL:CAC04240.1};
GN ORFNames=SC4B10.35 {ECO:0000313|EMBL:CAC04240.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAC04240.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAC04240.1, ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145
RC {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
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DR EMBL; AL939130; CAC04240.1; -; Genomic_DNA.
DR RefSeq; NP_631195.1; NC_003888.3.
DR RefSeq; WP_011031451.1; NZ_VNID01000012.1.
DR AlphaFoldDB; Q9FC52; -.
DR STRING; 100226.gene:17764794; -.
DR PaxDb; 100226-SCO7134; -.
DR PATRIC; fig|100226.15.peg.7235; -.
DR eggNOG; COG2909; Bacteria.
DR HOGENOM; CLU_006850_4_1_11; -.
DR InParanoid; Q9FC52; -.
DR OrthoDB; 7053960at2; -.
DR PhylomeDB; Q9FC52; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004016; F:adenylate cyclase activity; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR PANTHER; PTHR16305:SF35; TRANSCRIPTIONAL ACTIVATOR DOMAIN; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF00196; GerE; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001973}.
FT DOMAIN 854..920
FT /note="HTH luxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50043"
SQ SEQUENCE 923 AA; 98698 MW; B7560B5054A5B02C CRC64;
MVRDGAGTEL IGRQDECKVL DDLLAQARAG RSGVLVVRGE AGIGKTELLN HLLDGATGCR
VVRAVGVQSE MELSYAGLHQ LCAPLLSHLE SLPEPQRNAL RTAFGMQVGD APDRFLVGLA
TLSLLAAAVG DEPLLCMVDD AQWLDRVSAQ TLEFVARRLL AEPVLLVLAV RESGSREVLA
DLPELAVRGL GERESRELLD SVVTGPLDQR VRDRIVAETR GNPLALVELP RGLTLLEMAG
GFGVPESRPL SGRIEAGFLR RIRSLSAQTQ QLLLIAATEP VGDVSLLRSA AERLGIDVDR
AATEAEASGL MTLGTWVRFR HPLVRSAAYR AVGLEERRRV HAALAESIDA TLYPERRVWH
LASAATGPDE NVAAELEGSA GRAHARGGVA AAAAFLDRAT ALTPDPVRRG ARALAAARAK
YQAGAYDTAR ELVDAAELSH LDEAGAGRAT LLRGQIMSAA KSASAGLPLL LEAAKRLQPF
DPALADQTYR DAIYAALTAG RLATGGVRDV ADAVLSTPGH TGTESRETRL LTGLARVVTE
GYAAGAPVLL DAVAAFREGE FSAEDGLGWL PFACRMAHNT WDFAAWSELS ARLVDLAREN
GALAVLPSAL LLRLSNRVFA GDLRGAASLT VEASAIGEAT GSSFFAHYGA LVLEPFRGRE
PATRQAIETL TQDRLLRGEG KVTTATQWAA AVLYNGLGRY EEAYAAAERG CENPQEMGLS
LQSRVELVEA AVRLGRTERA AEAVRTIEEM AQVSGTPWAL GTSAAARALV SEGETADALH
REAIERLDTA GVRMDSARAR LRHGEWLRLE RRRAQARTRL SEAHEMLDAA GAEAFAERAR
RELKAVGVKV RGRATAETAV LTAKEVEIAR LVQGGFTNPE IGARLFLSPH TVEWHLRKVF
VKLGVSSRKE IDSVRLEAMA TAP
//
