ID Q9GN58_DROSI Unreviewed; 465 AA.
AC Q9GN58;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 24-JAN-2024, entry version 107.
DE RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240 {ECO:0000313|EMBL:AAG22967.1};
RN [1] {ECO:0000313|EMBL:AAG22967.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CT96_2s {ECO:0000313|EMBL:AAG22945.1}, CT96_5s
RC {ECO:0000313|EMBL:AAG22947.1}, CT96_6s {ECO:0000313|EMBL:AAG22949.1},
RC DPF96_3s {ECO:0000313|EMBL:AAG22943.1}, GA96_2s
RC {ECO:0000313|EMBL:AAG22957.1}, GA96_4s {ECO:0000313|EMBL:AAG22959.1},
RC GA96_5s {ECO:0000313|EMBL:AAG22961.1}, HFL97_1s
RC {ECO:0000313|EMBL:AAG22963.1}, HFL97_2s {ECO:0000313|EMBL:AAG22965.1},
RC HFL97_4s {ECO:0000313|EMBL:AAG22967.1}, VA96_7s
RC {ECO:0000313|EMBL:AAG22953.1}, and VA96_8s
RC {ECO:0000313|EMBL:AAG22955.1};
RX PubMed=11063694;
RA Duvernell D.D., Eanes W.F.;
RT "Contrasting molecular population genetics of four hexokinases in
RT Drosophila melanogaster, D. simulans and D. yakuba.";
RL Genetics 156:1191-1201(2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16126;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000435};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17826;
CC Evidence={ECO:0000256|ARBA:ARBA00000435};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000417};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:22741;
CC Evidence={ECO:0000256|ARBA:ARBA00000417};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004888}.
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|RuleBase:RU362007}.
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DR EMBL; AF257637; AAG22943.1; -; Genomic_DNA.
DR EMBL; AF257638; AAG22945.1; -; Genomic_DNA.
DR EMBL; AF257639; AAG22947.1; -; Genomic_DNA.
DR EMBL; AF257640; AAG22949.1; -; Genomic_DNA.
DR EMBL; AF257642; AAG22953.1; -; Genomic_DNA.
DR EMBL; AF257643; AAG22955.1; -; Genomic_DNA.
DR EMBL; AF257644; AAG22957.1; -; Genomic_DNA.
DR EMBL; AF257645; AAG22959.1; -; Genomic_DNA.
DR EMBL; AF257646; AAG22961.1; -; Genomic_DNA.
DR EMBL; AF257647; AAG22963.1; -; Genomic_DNA.
DR EMBL; AF257648; AAG22965.1; -; Genomic_DNA.
DR EMBL; AF257649; AAG22967.1; -; Genomic_DNA.
DR RefSeq; XP_016036400.1; XM_016177578.1.
DR AlphaFoldDB; Q9GN58; -.
DR EnsemblMetazoa; FBtr0364714; FBpp0328130; FBgn0042856.
DR GeneID; 6729739; -.
DR OrthoDB; 3539700at2759; -.
DR UniPathway; UPA00109; UER00180.
DR UniPathway; UPA00242; -.
DR Bgee; FBgn0042856; Expressed in male reproductive system and 2 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.40.367.20; -; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR PANTHER; PTHR19443:SF16; HEXOKINASE TYPE 1-RELATED; 1.
DR Pfam; PF00349; Hexokinase_1; 1.
DR Pfam; PF03727; Hexokinase_2; 1.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS51748; HEXOKINASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362007};
KW Glycolysis {ECO:0000256|RuleBase:RU362007};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362007};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362007};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362007}.
FT DOMAIN 14..208
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 215..447
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
SQ SEQUENCE 465 AA; 52236 MW; C8BACB03A522BE09 CRC64;
MANTFNPEED FPEVYKVCKL FNPSIDDLEK IKQAMDREIT MGLSRDHHDR STVPCHLSYV
QDLPTGRERG QFLALEMMPT NCRIMLVKFS SERDIYTSSK CVIMPHTVAA GRGTEVFTFL
ATIIANFVKE KKVDKDNLPL GIAFAFTLKK LALDVGILVS WTKEFGAQGA IGKDVVQLLR
DALAKFPEIS VDVMGIINVG AGSLLALCWA QPDTRIGLIM GSIANSCYVE RVERCETYEG
DEFRRLMIIN SDWAHFGDTG QLDFIRNEFD RLLDTDSINP GTRIYEKFSG ALCMGELVRI
IVLRLMKAGA IFAEDRRDYI GIQWKLDMVS LIEIVSDPPG VYTKAQEVMD KFRIRHCKER
DLAALKYICD TVTNRAAMLV ASGVSCLIDR MRLPQISIAV DGGIYRLHPT FATVLNKYTR
LLADPNYNFE FVITQDSCGV GAAIMAGMAH ANKYKTDAKL FTMDY
//
