ID Q9GQ88_DROME Unreviewed; 455 AA.
AC Q9GQ88;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Translation initiation factor eIF2B subunit gamma {ECO:0000256|ARBA:ARBA00044196};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit gamma {ECO:0000256|ARBA:ARBA00044229};
GN Name=eIF2Bgamma {ECO:0000313|FlyBase:FBgn0034029};
GN Synonyms=eIF2B-gamma {ECO:0000313|FlyBase:FBgn0034029};
GN ORFNames=CG8190 {ECO:0000313|FlyBase:FBgn0034029};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAG38016.1};
RN [1] {ECO:0000313|EMBL:AAG38016.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11060303; DOI=10.1074/jbc.M008041200;
RA Williams D.D., Pavitt G.D., Proud C.G.;
RT "Characterization of the initiation factor eIF2B and its regulation in
RT Drosophila melanogaster.";
RL J. Biol. Chem. 276:3733-3742(2001).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC {ECO:0000256|ARBA:ARBA00007878}.
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DR EMBL; AF289102; AAG38016.1; -; mRNA.
DR AlphaFoldDB; Q9GQ88; -.
DR AGR; FB:FBgn0034029; -.
DR FlyBase; FBgn0034029; eIF2Bgamma.
DR VEuPathDB; VectorBase:FBgn0034029; -.
DR HOGENOM; CLU_016743_0_0_1; -.
DR ExpressionAtlas; Q9GQ88; baseline and differential.
DR GO; GO:0005829; C:cytosol; ISS:FlyBase.
DR GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:FlyBase.
DR GO; GO:0032045; C:guanyl-nucleotide exchange factor complex; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; ISS:FlyBase.
DR GO; GO:0071456; P:cellular response to hypoxia; IMP:FlyBase.
DR GO; GO:0002183; P:cytoplasmic translational initiation; IBA:GO_Central.
DR GO; GO:0006413; P:translational initiation; ISS:FlyBase.
DR CDD; cd04198; eIF-2B_gamma_N; 1.
DR CDD; cd04652; LbH_eIF2B_gamma_C; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR45989; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA; 1.
DR PANTHER; PTHR45989:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 2: Evidence at transcript level;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 6..135
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 455 AA; 50685 MW; 6065ABD007515B9F CRC64;
MTEFRAVVFA AGRGTRLPEV LGDAPKCLLP VGPYPLIWYP LNLLQQHNFS EVIVVVLEQE
KLEIQSALEN TPLKLRLDYA TIPSDGDFGT ADSLRYIYDK IKSDFLVVSC DLVSNVSLYP
LINKFREHDA ALAMLLFPSG FESDVVMPGP KSKHKPERDL IGIHAATQRL AFVSAASDCE
ETLNIQRHLL KNRGRLDVYS RLVDAHVYVL KKWVIDYLRR KENISTFKGE FLPHLIKKQH
SKRPPKTVQD TTSEVGVVTK NEDHVLHYVG HTILDQKITQ TSLFNQSLSQ SPYHGDIVRC
YGIQAPRDAI GVRVNNTLSF LAINRKLASI WNNLCGEKHP LISPGAVVKS TQTKEIIAAD
NAKLSEKTSL NFSVFGPNCI ISPKNIVANS LIMSNAIVEE GCNIDNCIIG HRAQVKSGSV
LKNCIIGPNY VVEEGTHSQA VHLSNADQFM EIDIQ
//
