ID Q9GRI7_MUSDO Unreviewed; 468 AA.
AC Q9GRI7;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Bicoid protein {ECO:0000313|EMBL:CAC14290.1};
GN Name=bcd {ECO:0000313|EMBL:CAC14290.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:CAC14290.1};
RN [1] {ECO:0000313|EMBL:CAC14290.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=white {ECO:0000313|EMBL:CAC14290.1};
RX PubMed=11478522; DOI=10.1046/j.1525-142x.2001.003004251.x;
RA Shaw P.J., Salameh A., McGregor A.P., Bala S., Dover G.A.;
RT "Divergent structure and function of the bicoid gene in Muscoidea fly
RT species.";
RL Evol. Dev. 3:251-262(2001).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
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DR EMBL; AJ297853; CAC14290.1; -; mRNA.
DR PIR; A61600; A61600.
DR AlphaFoldDB; Q9GRI7; -.
DR VEuPathDB; VectorBase:MDOA003664; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR PANTHER; PTHR45664:SF19; HOMEOTIC PROTEIN BICOID; 1.
DR PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 74..134
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 76..135
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 468 AA; 51830 MW; 3C3818DD144F57C7 CRC64;
MAQPPPDQNF YHPHPHPHAH PHPHPQLQLP PQFRNPFDLL FDERTGAINY NYIRPYTPNQ
LPKPDDLSDS LVMRRPRRTR TTFTSAQIAE LEQHFLQGRY LTSSRLAELS AKLTLGTAQV
KIWFKNRRRR HKIQSDQQKE FSCDGMPLSP SLSTTIKSEP QGSASSCGSN NSNGSTSSSS
SSGGPPSLQS LSINGNGGST PNPLTPSPTP TTPTTNLMDH YSEPAFNPYY YNNHHSTHHH
HHQPPHHATL THPYGCSAGA TGGQYYPPPP PPSSLQHHHS QHQQQYHSPH PHQFQMEHKP
HAAVIKEDPD YNFNNPYYMR MPLTAGSNPS GVTTVEPSSA MSPNSEVYEP LTPKNDDNSS
LCNGAGGNVD VGDNLDETKA KLRVIVSSNA NRTDDTCSNT NAIGNEGSGT PAINIMEECT
GAFAKYQKMT TADPNDPNYQ CTMDTIMHAY NNHRNTSANN QQFAYCFN
//
