ID Q9GSL1_PHYPO Unreviewed; 536 AA.
AC Q9GSL1;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Fragmin60 {ECO:0000313|EMBL:AAG31138.1};
GN Name=frg60 {ECO:0000313|EMBL:AAG31138.1};
OS Physarum polycephalum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Myxogastria;
OC Myxogastromycetidae; Physariida; Physaraceae; Physarum.
OX NCBI_TaxID=5791 {ECO:0000313|EMBL:AAG31138.1};
RN [1] {ECO:0000313|EMBL:AAG31138.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12167630; DOI=10.1074/jbc.M207052200;
RA Sklyarova T., De Corte V., Meerschaert K., Bailey J., Cook L.J.,
RA Verschelde J.-L., Goethals M., Van Damme J., Puype M., Vandekerckhove J.,
RA Gettemans J.;
RT "Fragmin60 encodes an actin-binding protein with a C2 domain and controls
RT actin Thr-203 phosphorylation in Physarum plasmodia and sclerotia.";
RL J. Biol. Chem. 277:39840-39849(2002).
CC -!- SIMILARITY: Belongs to the villin/gelsolin family.
CC {ECO:0000256|ARBA:ARBA00008418}.
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DR EMBL; AF303112; AAG31138.1; -; mRNA.
DR AlphaFoldDB; Q9GSL1; -.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR CDD; cd11290; gelsolin_S1_like; 1.
DR CDD; cd11289; gelsolin_S2_like; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.40.20.10; Severin; 3.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR007122; Villin/Gelsolin.
DR PANTHER; PTHR11977:SF85; HP DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11977; VILLIN; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00626; Gelsolin; 3.
DR PRINTS; PR00597; GELSOLIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00262; GEL; 3.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 3.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
PE 2: Evidence at transcript level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..120
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 536 AA; 59822 MW; 3E6F1706FB641738 CRC64;
MEPKQGYLLV KLIEARKLAS KDVGGGSDPY AIVGLLNSKG EQGGLLDTKF PQYRSKVIQK
NLNPVWKDEG VYEFKPDIDG KARILHVQLW DEDVTYDDFL GQFNINPRDL PDGQLVDNWF
PVKNRPGKKE GVTGDVHLQL LYTRPPPDKL KPIREGPEEM TDPAYDKNLK VSIEASNIAN
LGTDLEKQVR LEAARHEAAW KSAGQKPGLE IWRIEKFTVK AWPVEEYGKF YNGDSYIILH
TYKKSPDSDA LAWDVHFWLG AYTSQDEAGT AAYKTVELDD FLGGAPVQHR EVQGYESELF
LSYFPQTIQI LGGGIESGFK HVKPAEYACR LLHLKGGKFV RIMQVELTTH SLNSGDAFIL
DDGVTIYQWQ GKSAGPNEKV KAGQIARSLK DERGSKPNII VIDESVDSGS ADFWNKLGGK
AKIATAAEGG SDLESDKKPT PKCLYRLSDA SGRLEFTLMA KDKVFRKHIT SADAFIFDTG
YHVFAWVGKA ASIPEKSKAL KYAQDYLKEH NRPDFIPISR ILDGGENVEF EAAFDG
//
