ID Q9H2E0_HUMAN Unreviewed; 83 AA.
AC Q9H2E0;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Neuropilin-1 {ECO:0000313|EMBL:AAG41893.1};
DE Flags: Fragment;
GN Name=NRP1 {ECO:0000313|EMBL:AAG41893.1};
GN Synonyms=DKFZp686M1967 {ECO:0000313|EMBL:CAH10397.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAG41893.1};
RN [1] {ECO:0000313|EMBL:AAG41893.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11112349; DOI=10.1006/geno.2000.6381;
RA Rossignol M., Gagnon M.L., Klagsbrun M.;
RT "Genomic organization of human neuropilin-1 and neuropilin-2 genes:
RT identification and distribution of splice variants and soluble isoforms.";
RL Genomics 70:211-222(2000).
RN [2] {ECO:0000313|EMBL:CAH10397.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Endometrium carcinoma cell line {ECO:0000313|EMBL:CAH10397.1};
RG The German cDNA Consortium;
RA Bahr A., Lauber J., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G.,
RA Han M., Wiemann S.;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AH010078; AAG41893.1; -; Genomic_DNA.
DR EMBL; AL833608; CAH10397.1; -; mRNA.
DR AlphaFoldDB; Q9H2E0; -.
DR PeptideAtlas; Q9H2E0; -.
DR ChiTaRS; NRP1; human.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00041; CUB; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR46806; F5/8 TYPE C DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46806:SF4; NEUROPILIN-1; 1.
DR Pfam; PF00431; CUB; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00059}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..83
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010847898"
FT DOMAIN 27..83
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 27..54
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT NON_TER 83
FT /evidence="ECO:0000313|EMBL:AAG41893.1"
SQ SEQUENCE 83 AA; 9376 MW; 398AA6A822A407BB CRC64;
MERGLPLLCA VLALVLAPAG AFRNDKCGDT IKIESPGYLT SPGYPHSYHP SEKCEWLIQA
PDPYQRIMIN FNPHFDLEDR DCK
//
