ID Q9HUS3_PSEAE Unreviewed; 209 AA.
AC Q9HUS3;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 147.
DE SubName: Full=DesT {ECO:0000313|EMBL:AAG08275.1};
GN Name=desT {ECO:0000313|EMBL:AAG08275.1};
GN OrderedLocusNames=PA4890 {ECO:0000313|EMBL:AAG08275.1};
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964 {ECO:0000313|EMBL:AAG08275.1, ECO:0000313|Proteomes:UP000002438};
RN [1] {ECO:0000313|EMBL:AAG08275.1, ECO:0000313|Proteomes:UP000002438}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC 1C / PRS 101 / PAO1 {ECO:0000313|Proteomes:UP000002438};
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R., Smith K.,
RA Spencer D., Wong G.K., Wu Z., Paulsen I.T., Reizer J., Saier M.H.,
RA Hancock R.E., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [2] {ECO:0007829|PDB:3LSJ, ECO:0007829|PDB:3LSP}
RP X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH COENZYME A.
RX PubMed=20639888; DOI=10.1038/nsmb.1847;
RA Miller D.J., Zhang Y.M., Subramanian C., Rock C.O., White S.W.;
RT "Structural basis for the transcriptional regulation of membrane lipid
RT homeostasis.";
RL Nat. Struct. Mol. Biol. 17:971-975(2010).
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DR EMBL; AE004091; AAG08275.1; -; Genomic_DNA.
DR PIR; D83034; D83034.
DR RefSeq; NP_253577.1; NC_002516.2.
DR RefSeq; WP_003107570.1; NZ_QZGE01000002.1.
DR PDB; 3LSJ; X-ray; 2.30 A; A/B=1-209.
DR PDB; 3LSP; X-ray; 2.66 A; A=1-209.
DR PDB; 3LSR; X-ray; 2.55 A; A=1-209.
DR PDBsum; 3LSJ; -.
DR PDBsum; 3LSP; -.
DR PDBsum; 3LSR; -.
DR AlphaFoldDB; Q9HUS3; -.
DR SMR; Q9HUS3; -.
DR DIP; DIP-59031N; -.
DR STRING; 208964.PA4890; -.
DR PaxDb; 208964-PA4890; -.
DR DNASU; 882265; -.
DR GeneID; 882265; -.
DR KEGG; pae:PA4890; -.
DR PATRIC; fig|208964.12.peg.5123; -.
DR PseudoCAP; PA4890; -.
DR HOGENOM; CLU_081861_3_0_6; -.
DR InParanoid; Q9HUS3; -.
DR OrthoDB; 8617654at2; -.
DR PhylomeDB; Q9HUS3; -.
DR BioCyc; PAER208964:G1FZ6-5004-MONOMER; -.
DR EvolutionaryTrace; Q9HUS3; -.
DR Proteomes; UP000002438; Chromosome.
DR CollecTF; EXPREG_00001570; -.
DR GO; GO:0032993; C:protein-DNA complex; IPI:CollecTF.
DR GO; GO:0001217; F:DNA-binding transcription repressor activity; IPI:CollecTF.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:CollecTF.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; EXP:CollecTF.
DR GO; GO:0045922; P:negative regulation of fatty acid metabolic process; IMP:PseudoCAP.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR PANTHER; PTHR47752; HTH-TYPE TRANSCRIPTIONAL REPRESSOR FABR; 1.
DR PANTHER; PTHR47752:SF1; HTH-TYPE TRANSCRIPTIONAL REPRESSOR FABR; 1.
DR Pfam; PF00440; TetR_N; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3LSJ, ECO:0007829|PDB:3LSP};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW Reference proteome {ECO:0000313|Proteomes:UP000002438};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 10..71
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 34..53
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
FT BINDING 195
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0007829|PDB:3LSJ"
FT BINDING 203
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0007829|PDB:3LSJ"
FT BINDING 205
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0007829|PDB:3LSJ"
SQ SEQUENCE 209 AA; 22899 MW; CE3EE8F29C0D0C1A CRC64;
MSSPRAEQKQ QTRHALMSAA RHLMESGRGF GSLSLREVTR AAGIVPAGFY RHFSDMDQLG
LALVAEVDET FRATLRAVRR NEFELGGLID ASVRIFLDAV GANRSQFLFL AREQYGGSLP
IRQAIASLRQ RITDDLAADL ALLNKMPHLD GAALDVFADL VVKTVFATLP ELIDPPAADL
PPHLMPAAKI THQLRFIMIG GKHWHGLPG
//