ID Q9HWM4_PSEAE Unreviewed; 262 AA.
AC Q9HWM4;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 134.
DE SubName: Full=Probable transcriptional regulator {ECO:0000313|EMBL:AAG07544.1};
GN OrderedLocusNames=PA4157 {ECO:0000313|EMBL:AAG07544.1};
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964 {ECO:0000313|EMBL:AAG07544.1, ECO:0000313|Proteomes:UP000002438};
RN [1] {ECO:0000313|EMBL:AAG07544.1, ECO:0000313|Proteomes:UP000002438}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC 1C / PRS 101 / PAO1 {ECO:0000313|Proteomes:UP000002438};
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R., Smith K.,
RA Spencer D., Wong G.K., Wu Z., Paulsen I.T., Reizer J., Saier M.H.,
RA Hancock R.E., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE004091; AAG07544.1; -; Genomic_DNA.
DR PIR; B83126; B83126.
DR RefSeq; NP_252846.1; NC_002516.2.
DR RefSeq; WP_003119004.1; NZ_QZGE01000013.1.
DR AlphaFoldDB; Q9HWM4; -.
DR SMR; Q9HWM4; -.
DR STRING; 208964.PA4157; -.
DR PaxDb; 208964-PA4157; -.
DR DNASU; 880161; -.
DR GeneID; 880161; -.
DR KEGG; pae:PA4157; -.
DR PATRIC; fig|208964.12.peg.4355; -.
DR PseudoCAP; PA4157; -.
DR HOGENOM; CLU_062618_2_0_6; -.
DR InParanoid; Q9HWM4; -.
DR OrthoDB; 6811967at2; -.
DR PhylomeDB; Q9HWM4; -.
DR BioCyc; PAER208964:G1FZ6-4230-MONOMER; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR30136; HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, ICLR FAMILY; 1.
DR PANTHER; PTHR30136:SF8; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF09339; HTH_IclR; 1.
DR Pfam; PF01614; IclR; 1.
DR SMART; SM00346; HTH_ICLR; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51077; HTH_ICLR; 1.
DR PROSITE; PS51078; ICLR_ED; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002438};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 13..75
FT /note="HTH iclR-type"
FT /evidence="ECO:0000259|PROSITE:PS51077"
FT DOMAIN 76..257
FT /note="IclR-ED"
FT /evidence="ECO:0000259|PROSITE:PS51078"
SQ SEQUENCE 262 AA; 28015 MW; 44B183B6DF9BAB15 CRC64;
MPDAPGEKRS GTIQSVSIAA RFLKTLANAE GELALGEVAR RTGTGGSTAH RYLQSLVKEG
LARQDPLSGL YDLGPAALSI GIGALKRIDA VDIAARHMKA LAQRHAASGG VAIWTERGPT
LVRWYRSAYF SINPLALGDI LPIDNTACGL VFQAFLPKAV VDAARKQQPA HFRGSPPSRA
LLDEVRERCW AELTSHLLSN VTGQAAPVFD AQQEIVCAMT TVTDLGQLQS AEDRDALFHE
ALQVNQSTGG LVLHPGMRPP PR
//
