ID Q9HX42_PSEAE Unreviewed; 795 AA.
AC Q9HX42;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 135.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN Name=ladS {ECO:0000313|EMBL:AAG07361.1};
GN OrderedLocusNames=PA3974 {ECO:0000313|EMBL:AAG07361.1};
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964 {ECO:0000313|EMBL:AAG07361.1, ECO:0000313|Proteomes:UP000002438};
RN [1] {ECO:0000313|EMBL:AAG07361.1, ECO:0000313|Proteomes:UP000002438}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC 1C / PRS 101 / PAO1 {ECO:0000313|Proteomes:UP000002438};
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R., Smith K.,
RA Spencer D., Wong G.K., Wu Z., Paulsen I.T., Reizer J., Saier M.H.,
RA Hancock R.E., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; AE004091; AAG07361.1; -; Genomic_DNA.
DR PIR; D83149; D83149.
DR RefSeq; NP_252663.1; NC_002516.2.
DR RefSeq; WP_003114327.1; NZ_QZGE01000001.1.
DR AlphaFoldDB; Q9HX42; -.
DR SMR; Q9HX42; -.
DR STRING; 208964.PA3974; -.
DR PaxDb; 208964-PA3974; -.
DR GeneID; 878890; -.
DR KEGG; pae:PA3974; -.
DR PATRIC; fig|208964.12.peg.4166; -.
DR PseudoCAP; PA3974; -.
DR HOGENOM; CLU_000445_105_2_6; -.
DR InParanoid; Q9HX42; -.
DR OrthoDB; 9797243at2; -.
DR PhylomeDB; Q9HX42; -.
DR BioCyc; PAER208964:G1FZ6-4048-MONOMER; -.
DR BRENDA; 2.7.13.3; 5087.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009927; F:histidine phosphotransfer kinase activity; IBA:GO_Central.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IBA:GO_Central.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 2.60.40.2380; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR011623; 7TMR_DISM_rcpt_extracell_dom1.
DR InterPro; IPR011622; 7TMR_DISM_rcpt_extracell_dom2.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR45339; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR PANTHER; PTHR45339:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR Pfam; PF07695; 7TMR-DISM_7TM; 1.
DR Pfam; PF07696; 7TMR-DISMED2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000002438};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..795
FT /note="histidine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004328305"
FT TRANSMEM 183..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 425..645
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 669..785
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT COILED 391..425
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 718
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 795 AA; 88206 MW; 516B2B5F5299CA75 CRC64;
MRHWLILFLL ALPCLAGAVS FNEQVERLPL GQSIDVFEDV RGSADINDIT SRAIDSSFRR
HDKDVLNAGY SRSVFWLRLD LDYRPVASSD PRTWLLELAY PPLDKLDLYL PDGQGGYRLA
QRTGDTLPFA SRPIRQNNYL FELGLEPNKP QRVYLRLESQ GSIQAPLTLW SPKAYLEEQP
ERIYVLGIIY GVLLVMLIYN LFIFLSVRDT SYLYYILYIA SFGLYQVSVN GAGIEYFWPD
SPWWANAATP FLIGSAALFG CQFARSFLHT RDHSVWVDRG LLALMAVGAL VMLMALTMSY
AVALRLATYL ALAFTGLIFA AGILAWLRGM RVARYFIIAW TAFLLGGIVN TLMVLGYLPN
MFLTMYASQI GSALEVGLLS LALADRINAM KEERARILQE SSRKLEALNQ ELANSNRLKD
EFLATVTHEL RTPMSGVIGS LELMQTVPMD VELAEYQRTA AGSARDMMRM VNDILALIEL
QAGKLYPRRE PFSLRGLFDS LRAQYAPRVE EKGLRFALQL DDSLPDTLEG DAGKLAQALG
YLVDNAIKFT ARGSVTLRVA AGRTHDGVAL RVEVIDTGIG FDMAAGSDLY QRFVQADSSL
TRGYGGLGIG LALCRKLVEL LGGELTHESR PGQGSRFLLR LQLTQPAQGL APPPRRAGGQ
AVRRPEECTV LVVEDNAINQ LVTRGMLLKL GYRVRTADNG SEALELLARE RPDGVLLDCQ
MPVMDGFATC RAIRALPGCA ELPVLALTAH SHSGDRERCL AAGMSDYMAK PVKFEELQTL
LHDWLLCQPI VTKSA
//
