ID Q9I8Q7_LITPI Unreviewed; 106 AA.
AC Q9I8Q7;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Insulin {ECO:0000256|RuleBase:RU000406};
OS Lithobates pipiens (Northern leopard frog) (Rana pipiens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX NCBI_TaxID=8404 {ECO:0000313|EMBL:AAF87285.1};
RN [1] {ECO:0000313|EMBL:AAF87285.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10818274; DOI=10.1016/S0305-0491(99)00182-0;
RA Irwin D.M., Sivarajah P.;
RT "Proinsulin cDNAs from the leopard frog, Rana pipiens: evolution of
RT proinsulin processing.";
RL Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 125:405-410(2000).
CC -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC cell permeability to monosaccharides, amino acids and fatty acids. It
CC accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC synthesis in liver. {ECO:0000256|ARBA:ARBA00002985,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds. {ECO:0000256|RuleBase:RU000406}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR EMBL; AF227187; AAF87285.1; -; mRNA.
DR AlphaFoldDB; Q9I8Q7; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04367; IlGF_insulin_like; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR004825; Insulin.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR11454:SF9; INSULIN; 1.
DR PANTHER; PTHR11454; INSULIN/INSULIN GROWTH FACTOR; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR00277; INSULIN.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 2: Evidence at transcript level;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277,
KW ECO:0000256|RuleBase:RU000406};
KW Glucose metabolism {ECO:0000256|ARBA:ARBA00022526,
KW ECO:0000256|RuleBase:RU000406};
KW Hormone {ECO:0000256|ARBA:ARBA00022702, ECO:0000256|RuleBase:RU000406};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..106
FT /note="Insulin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004327608"
FT DOMAIN 27..105
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
SQ SEQUENCE 106 AA; 12183 MW; 3A870EEC70217F92 CRC64;
MALWIQCLHI AVLLSLFTPT LKTFDNQYLC GSHLVEALYM VCGDRGFFYS PRSRRDLEQP
LVNGLQGSEL DEMQVQSQAF QKRKPGIVEQ CCHNTCSLYD LENYCN
//
