ID Q9IBF1_TAKPA Unreviewed; 1880 AA.
AC Q9IBF1;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Takifugu pardalis (Panther puffer) (Tetraodon pardalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=98921 {ECO:0000313|EMBL:BAA90398.1};
RN [1] {ECO:0000313|EMBL:BAA90398.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:BAA90398.1};
RX PubMed=10623632; DOI=10.1006/bbrc.1999.1974;
RA Yotsu-Yamashita M., Nishimori K., Nitanai Y., Isemura M., Sugimoto A.,
RA Yasumoto T.;
RT "Binding properties of (3)H-PbTx-3 and (3)H-saxitoxin to brain membranes
RT and to skeletal muscle membranes of puffer fish Fugu pardalis and the
RT primary structure of a voltage-gated Na(+) channel alpha-subunit (fMNa1)
RT from skeletal muscle of F. pardalis.";
RL Biochem. Biophys. Res. Commun. 267:403-412(2000).
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC Nav1.4/SCN4A subfamily. {ECO:0000256|ARBA:ARBA00038083}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; AB030482; BAA90398.1; -; mRNA.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF223; SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50096; IQ; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132, ECO:0000313|EMBL:BAA90398.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 121..140
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 185..204
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 216..237
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 398..425
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 592..616
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 628..649
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 669..690
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 711..739
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 801..824
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1059..1077
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1098..1114
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1126..1146
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1175..1201
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1300..1323
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1382..1400
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1412..1434
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1446..1465
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1509..1535
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1603..1626
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 1643..1678
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 34..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 933..968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1824..1844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 422..456
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 34..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..893
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..956
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1880 AA; 212087 MW; 406483C6C3D43E02 CRC64;
MATILPPPGT ALFRHFTRQS LATIERLKEE TLIAPKAGAH EEEEPPTPNP DLEAGKSLPM
IFGDPPSELL GTPLEDIDPF YKAQKTFVVV TKGNTIYRFN AEPACYILSP FSLVRRGAIK
ILIHSLIMIT ILSNCVFMTM SNPPAWSKTV EYVFTGIYTF EATVKVLSRG FCVGPFTFLR
DPWNWLDFMV ISMAYITEFV DLGNVSALRT FRVLRALKTI TVIPGLKTIV AALIQSVKKM
VDVMILTVFA LAVFALVGLQ LFMGNLRHKC IRWPIANETA SELFNGTVFN DTLSYNDTTW
PNDTLYSNST FDFTEYIENA ENQYFLEGSK DALLCGNGTD AGKCPEGYLC MKAGRNPNYG
YTSFDSFGWA FLALFRLMTQ DNWESLFQLT LRAGGQTYML FFVVVIFLGS FYLINLILAV
VAMAYDEQNQ ASQQEAKEKE EEFQRLLEQL KNQEQAQVLG SRASLTSKKS VSLTSDVADD
EQSLENNEAL KDCNGRPIPR LIFRAPTMKE SAADYELREK EESSVHSVVH LEEPGLRERS
ASVATAAASV ATAAAMEELE EAQRPCPPIW YRFADIFLKW NCCEKWVVFK EWVHFVVMDP
FVDLAITICI VLNTLFMAME HYPMTEEFDY MLSVGNLVFT GIFAAEMFFK LIAMDPYYYF
QVGWNIFDSI IVTLSLVELG LANVQGLSVL RSFRLLRVFK LAKSWPTLNM LIKIIGNSVG
ALGNLTLVLA IIVFIFAVVG MQLFGKSYKD CVCKISSDCE LPRWHMNDFF HSFLIVFRIL
CGEWIETMWD CMEVAGAGMC LVVFMMVMVI GNLVVLNLFL ALLLSSFSGD NLSVGDDDGE
LNNLQIAIGR ITRGGNWLKA FFIGTLQRVL GREPQKPAEE DPADEGEGKT EGMEMNHLDG
FKLADGIANC LVGGQPSGVT LDGESSITVP IALGESDSEN PSEDDDDQED DVDSEVTCEE
NEHHSDGVED EFGVLQHVKL MGALTDGDSS VCSTVDYQPP EPEVQEEEEE EPDLVEPEAC
FTDNCVKRWP CLNVDISQGK GKKWWNLRKT CFTIVEHDWF ETFIIFMILL SSGALAFEDI
YIERRRTVKI VLEFADKVFT FIFVIEMLLK WVAYGFKTYF TNAWCWLDFF IVDISLISLS
ANLMGFSDLG PIKSLRTLRA LRPLRALSRF EGMRVVVNAL IGAIPSIFNV LLVCLIFWLI
FSIMGVNLFA GKFYRCINTT TAELFPISVV NNKSDCVALQ EATQEARWVN VKVNYDNVAK
GYLSLLQIAT FKGWMDIMYP AVDSREVEEQ PSYEINLYMY IYFVIFIIFG SFFTLNLFIG
VIIDNFNQQK KKLGDKDIFM TEEQKKYYEA MKKLGSKKPQ KPIPRPANLI QGLVFDFISQ
QFFDIFIMVL ICLNMVTMMV ETDDQSPAKE DFLFKVNVAF IVVFTGECTL KLIALRHYFF
TNGWNIFDFI VVILSIAGTM LSDIIEKYFV SPTLFRVIRL ARIGRILRLI KGARGIRTLL
FALMMSLPAL FNIGLLLFLI MFIFSIFGMS NFAYVKKEAG INDMFNFETF GSSIICLFQI
TTSAGWDTLL LPMLNKEPPD CDPAFENPGT DVKGNCGNPM MGMVFFCSYI IISFLVVVNM
YIAIILENFN VAQEESGDVL CEEDFEMFNE TWEKFDTGGT QFIEYSQLSD FCDALQEPLR
VAKPNRQRLI EMDLPLVIGD RIHCVDVLLA VTQEVLGDTI EMVAMRESIE AKFNLNNPTS
ASYAPITTTV RQKEEDMAAV VIQRAYRNHL HKRGIHHAAY IQRSKTGRKA ATEDAPEKEG
LLAQKMGALY GSDADLAEEV EGLRRRPDPQ TRCSGARCSP EPPEPNIILV PVEITNELLL
HSAPSQQSSP TQTILRETNV
//
