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Database: UniProt
Entry: Q9J2M7_9GAMA
LinkDB: Q9J2M7_9GAMA
Original site: Q9J2M7_9GAMA 
ID   Q9J2M7_9GAMA            Unreviewed;       188 AA.
AC   Q9J2M7;
DT   01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2000, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE            EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN   Name=ORF02 {ECO:0000313|EMBL:AAF59981.1};
OS   Rhesus monkey rhadinovirus H26-95.
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Orthoherpesviridae; Gammaherpesvirinae; Rhadinovirus;
OC   Rhadinovirus macacinegamma5; Macacine gammaherpesvirus 5.
OX   NCBI_TaxID=69256 {ECO:0000313|EMBL:AAF59981.1, ECO:0000313|Proteomes:UP000162467};
RN   [1] {ECO:0000313|EMBL:AAF59981.1, ECO:0000313|Proteomes:UP000162467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Macaca mulatta rhadinovirus isolate 26-95
RC   {ECO:0000313|EMBL:AAF59981.1};
RX   PubMed=10708456; DOI=10.1128/JVI.74.7.3388-3398.2000;
RA   Alexander L., Denekamp L., Knapp A., Auerbach M.R., Damania B.,
RA   Desrosiers R.C.;
RT   "The primary sequence of rhesus monkey rhadinovirus isolate 26-95: sequence
RT   similarities to Kaposi's sarcoma-associated herpesvirus and rhesus monkey
RT   rhadinovirus isolate 17577.";
RL   J. Virol. 74:3388-3398(2000).
CC   -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-
CC       tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00004903}.
CC   -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC       {ECO:0000256|RuleBase:RU004474}.
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DR   EMBL; AF210726; AAF59981.1; -; Genomic_DNA.
DR   Proteomes; UP000162467; Genome.
DR   GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR   GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro.
DR   CDD; cd00209; DHFR; 1.
DR   Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR   InterPro; IPR012259; DHFR.
DR   InterPro; IPR024072; DHFR-like_dom_sf.
DR   InterPro; IPR017925; DHFR_CS.
DR   InterPro; IPR001796; DHFR_dom.
DR   PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR   PANTHER; PTHR48069:SF6; DIHYDROFOLATE REDUCTASE; 1.
DR   Pfam; PF00186; DHFR_1; 1.
DR   PRINTS; PR00070; DHFR.
DR   SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR   PROSITE; PS00075; DHFR_1; 1.
DR   PROSITE; PS51330; DHFR_2; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          4..184
FT                   /note="DHFR"
FT                   /evidence="ECO:0000259|PROSITE:PS51330"
SQ   SEQUENCE   188 AA;  22051 MW;  C84CD476F7CA7537 CRC64;
     MDIAVNCIVA VDEQLGIGKN GTMPWPYLRN EMMYFQKMTS TPSVVGEKNV VIMGKRTWFS
     IPEKKRPLVN RINIILSREL REPPHGAHFL ARTLDDAFNF YRQYKLKEQL NTVWVIGGKS
     VYESVLNYKC PLKLYITRIM ESFDCDVFFP SINFTEYTML SELPGKDTNF EENGIKYKFQ
     VYEKNFNK
//
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