ID Q9K193_NEIMB Unreviewed; 766 AA.
AC Q9K193;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 141.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=recQ {ECO:0000313|EMBL:AAF40728.1};
GN OrderedLocusNames=NMB0274 {ECO:0000313|EMBL:AAF40728.1};
OS Neisseria meningitidis serogroup B (strain MC58).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=122586 {ECO:0000313|EMBL:AAF40728.1, ECO:0000313|Proteomes:UP000000425};
RN [1] {ECO:0000313|EMBL:AAF40728.1, ECO:0000313|Proteomes:UP000000425}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC58 {ECO:0000313|EMBL:AAF40728.1,
RC ECO:0000313|Proteomes:UP000000425};
RX PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA Tettelin H., Saunders N.J., Heidelberg J., Jeffries A.C., Nelson K.E.,
RA Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA Gwinn M.L., DeBoy R., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L.,
RA White O., Fleischmann R.D., Dougherty B.A., Mason T., Ciecko A.,
RA Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA Utterback T.R., Khouri H., Qin H., Vamathevan J., Gill J., Scarlato V.,
RA Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA Moxon E.R., Rappuoli R., Venter J.C.;
RT "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT MC58.";
RL Science 287:1809-1815(2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; AE002098; AAF40728.1; -; Genomic_DNA.
DR PIR; G81216; G81216.
DR RefSeq; NP_273330.1; NC_003112.2.
DR RefSeq; WP_002221929.1; NC_003112.2.
DR AlphaFoldDB; Q9K193; -.
DR STRING; 122586.NMB0274; -.
DR PaxDb; 122586-NMB0274; -.
DR KEGG; nme:NMB0274; -.
DR PATRIC; fig|122586.8.peg.341; -.
DR HOGENOM; CLU_001103_14_2_4; -.
DR InParanoid; Q9K193; -.
DR OrthoDB; 9760034at2; -.
DR Proteomes; UP000000425; Chromosome.
DR GO; GO:0043590; C:bacterial nucleoid; IBA:GO_Central.
DR GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030894; C:replisome; IBA:GO_Central.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0009378; F:four-way junction helicase activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0032508; P:DNA duplex unwinding; IBA:GO_Central.
DR GO; GO:0006310; P:DNA recombination; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR006293; DNA_helicase_ATP-dep_RecQ_bac.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR01389; recQ; 1.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 3.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 3.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 3.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:AAF40728.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AAF40728.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000425}.
FT DOMAIN 27..195
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 216..366
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 524..604
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT DOMAIN 610..690
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT DOMAIN 691..766
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
SQ SEQUENCE 766 AA; 85960 MW; 01726F0D2C14D09F CRC64;
MHRPTAKQIL HEVFGYPEFR GRQEAVINTL AGGGSLTVLM PTGGGKSLCY QIPALMREGV
AVVVSPLIAL MNDQVANLHA AGIEAAAVNS GTSADEAREI ADRLAQGRLK LLYVAPERLV
TDRFLRFLDQ QTVSLFAIDE AHCVSQWGHD FRPEYQQLGM LAERYPNVPR IALTATADAA
TRADIKHYLH LDDAPEFVSS FDRPNIYYQV IEKNNGKKQL LDFIRKEMTG QSGIVYCLSR
KKVEDVAQFL RENGLNAIPY HAGLSMDVRE ENQRRFTHED NIIVVATVAF GMGIDKPDVR
FVAHLDMPQS VEHFYQESGR AGRDGLPAAS WLCYGLNDWV LLRERIAEGN SDEVQKQIEM
QKLDAMLAVC ETAACRRVLL LKHFGEASEP CGHCDNCLHP PVRFDGTVLV QKLLSCVYRA
GQRFAAGYIT NILRGKSDDW IRGNRHEQLS TFGIGTELSD KEWRSVIRQC ISLGYLTVNI
TRYQALQLTE AAKKVLKGET EVMLRPLKRD KPAARTLKDN WLRTEREERL WQALRVWRMK
QAEAEGIPAY MIFGDKTLRD LVEKMPQDLN GLHDIYGLGE AKIDRFGHGI LEVCRNAAGF
SRDAVIRPQT EREQQLRQKL EAWRYEQARA ENCALHAVLS DESLADMLAD TPETETDLEG
VYGLGSVRAA KYGRDILAVC RPFSDGIDET AKRKRRLMRA LIQWCGETAK HEQSEPYRIL
SKAALRAIAA KQPEGLAELA AVYGVGEEKA ARYGAAVLAV LERNAV
//
