ID Q9K5J8_BACAN Unreviewed; 111 AA.
AC Q9K5J8; A0A2P0HAY6; E9QY83; E9QY84; E9QY85; Q6I2I0; Q6KWA8; Q81U92;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 24-JAN-2024, entry version 157.
DE RecName: Full=Anti-sigma factor antagonist {ECO:0000256|RuleBase:RU003749};
GN Name=rsbV {ECO:0000313|EMBL:CAB95032.1};
GN OrderedLocusNames=GBAA_0990 {ECO:0000313|EMBL:AAT30093.1};
OS Bacillus anthracis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392 {ECO:0000313|EMBL:CAB95032.1};
RN [1] {ECO:0000313|EMBL:CAB95032.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=9131 {ECO:0000313|EMBL:CAB95032.1};
RX PubMed=10960085; DOI=10.1128/JB.182.18.5036-5045.2000;
RA Fouet A., Namy O., Lambert G.;
RT "Characterization of the operon encoding the alternative sigma(B) factor
RT from Bacillus anthracis and its role in virulence.";
RL J. Bacteriol. 182:5036-5045(2000).
RN [2] {ECO:0000313|EMBL:AAT30093.1, ECO:0000313|Proteomes:UP000000594}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor {ECO:0000313|Proteomes:UP000000594}, and Ames
RC Ancestor {ECO:0000313|EMBL:AAT30093.1};
RX PubMed=18952800; DOI=10.1128/JB.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
CC -!- FUNCTION: Positive regulator of sigma-B activity. Non-phosphorylated
CC RsbV binds to RsbW, preventing its association with sigma-B. When
CC phosphorylated, releases RsbW, which is then free to complex with and
CC inactivate sigma-B. {ECO:0000256|ARBA:ARBA00024670}.
CC -!- SIMILARITY: Belongs to the anti-sigma-factor antagonist family.
CC {ECO:0000256|ARBA:ARBA00009013, ECO:0000256|RuleBase:RU003749}.
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DR EMBL; AE017334; AAT30093.1; -; Genomic_DNA.
DR EMBL; AJ272497; CAB95032.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9K5J8; -.
DR DNASU; 1088925; -.
DR KEGG; bar:GBAA_0990; -.
DR HOGENOM; CLU_115403_9_3_9; -.
DR OMA; MNLAINI; -.
DR Proteomes; UP000000594; Chromosome.
DR GO; GO:0043856; F:anti-sigma factor antagonist activity; IEA:InterPro.
DR CDD; cd07043; STAS_anti-anti-sigma_factors; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR003658; Anti-sigma_ant.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00377; ant_ant_sig; 1.
DR PANTHER; PTHR33495; ANTI-SIGMA FACTOR ANTAGONIST TM_1081-RELATED-RELATED; 1.
DR PANTHER; PTHR33495:SF9; ANTI-SIGMA-B FACTOR ANTAGONIST; 1.
DR Pfam; PF01740; STAS; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000594}.
FT DOMAIN 16..111
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 111 AA; 12494 MW; D82F4E2B2D8A7AE0 CRC64;
MNLGINILQN DVGYTVQLNG EIDAYTASDL KNKIMPIASE KEVRIVVDFN KVDYMDSTGL
GVFIALLKAV KKNDGKLEFI GVSKRLKRLF DITGLTEILN LNSDFEKVER R
//
