ID Q9KLU5_VIBCH Unreviewed; 605 AA.
AC Q9KLU5;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=L-ornithine N(alpha)-acyltransferase {ECO:0000256|ARBA:ARBA00039866};
DE EC=2.3.2.30 {ECO:0000256|ARBA:ARBA00039058};
GN OrderedLocusNames=VC_A0646 {ECO:0000313|EMBL:AAF96547.1};
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277 {ECO:0000313|EMBL:AAF96547.1, ECO:0000313|Proteomes:UP000000584};
RN [1] {ECO:0000313|EMBL:AAF96547.1, ECO:0000313|Proteomes:UP000000584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961
RC {ECO:0000313|Proteomes:UP000000584};
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D., Ermolaeva M.D.,
RA Vamathevan J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.,
RA Utterback T., Fleishmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3R)-hydroxyacyl-[ACP] + L-ornithine = a lyso-ornithine
CC lipid + H(+) + holo-[ACP]; Xref=Rhea:RHEA:20633, Rhea:RHEA-COMP:9685,
CC Rhea:RHEA-COMP:9945, ChEBI:CHEBI:15378, ChEBI:CHEBI:46911,
CC ChEBI:CHEBI:64479, ChEBI:CHEBI:78827, ChEBI:CHEBI:138482;
CC EC=2.3.2.30; Evidence={ECO:0000256|ARBA:ARBA00036203};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20634;
CC Evidence={ECO:0000256|ARBA:ARBA00036203};
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- SIMILARITY: Belongs to the acetyltransferase family. OlsB subfamily.
CC {ECO:0000256|ARBA:ARBA00038095}.
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DR EMBL; AE003853; AAF96547.1; -; Genomic_DNA.
DR PIR; D82434; D82434.
DR AlphaFoldDB; Q9KLU5; -.
DR STRING; 243277.VC_A0646; -.
DR DNASU; 2612265; -.
DR EnsemblBacteria; AAF96547; AAF96547; VC_A0646.
DR KEGG; vch:VC_A0646; -.
DR eggNOG; COG0204; Bacteria.
DR eggNOG; COG3176; Bacteria.
DR HOGENOM; CLU_033329_1_0_6; -.
DR Proteomes; UP000000584; Chromosome 2.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd07986; LPLAT_ACT14924-like; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR InterPro; IPR045746; ACT14924-like_Acyltransf_dom.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR002123; Plipid/glycerol_acylTrfase.
DR PANTHER; PTHR37323; GCN5-RELATED N-ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR37323:SF1; L-ORNITHINE N(ALPHA)-ACYLTRANSFERASE; 1.
DR Pfam; PF13444; Acetyltransf_5; 1.
DR Pfam; PF19576; Acyltransf_2; 1.
DR SMART; SM00563; PlsC; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR SUPFAM; SSF69593; Glycerol-3-phosphate (1)-acyltransferase; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022516};
KW Reference proteome {ECO:0000313|Proteomes:UP000000584};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 99..222
FT /note="Phospholipid/glycerol acyltransferase"
FT /evidence="ECO:0000259|SMART:SM00563"
SQ SEQUENCE 605 AA; 67612 MW; 4BCEA7841955EB46 CRC64;
MGKRSGASYR SRRPKLACAD WDKRMMQTQP FRLPRFTPFG VIEKGVELAT GLSQLERYYQ
QRPTTRDGFE FMRYTLEALN VHYQVDRGRV EQIPAQGPVV IVANHPLGAI EGVILADLVG
QVRKDVKVLA NQLLKRLPEI EPLFIGVDVF NGAQASKTNA RGIREAHRHL AEGGVLIVFP
AGEVSTPQKE TGQLSDIDWS QSVAKFIQRS QARCVPIYIH GRNSAWFYRA GKIHPLLRTA
MLGRELLNKS ASTISLCIGQ PIPYAELKEF TKDEDVVNYL RLNTYLMSPH GQVESAKVSF
TIPVIDPVPK AALIAELAQL DKQAKLLEQG EFTVYCVPST HIPLMMQEIG RVREISFRAV
GEGSGQACDV DAYDHHYWQL FVWNREQSEL VGAYRMGLVD KIVAERGLQG LYSRSLFHYD
HAFLATLENA IELGRSVVAE QYQRNLNSLL LLWKGIARFV ELNPHYTHLF GPVSISNDYS
PAARQLMAAT LSIHHYDQHK AALVSPSTPL RAGTEVFWQK SLLSALASVS LLSKVVARME
QGNGLPVLLR QYLGMNGKLV CLNVDPAFND ALDGLIVVNL KQVPLKTLAK YMGKEAAQHY
LCSVT
//
