ID Q9KUU3_VIBCH Unreviewed; 481 AA.
AC Q9KUU3;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=TldD protein {ECO:0000313|EMBL:AAF93595.1};
GN OrderedLocusNames=VC_0422 {ECO:0000313|EMBL:AAF93595.1};
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277 {ECO:0000313|EMBL:AAF93595.1, ECO:0000313|Proteomes:UP000000584};
RN [1] {ECO:0000313|EMBL:AAF93595.1, ECO:0000313|Proteomes:UP000000584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961
RC {ECO:0000313|Proteomes:UP000000584};
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D., Ermolaeva M.D.,
RA Vamathevan J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.,
RA Utterback T., Fleishmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
CC -!- SIMILARITY: Belongs to the peptidase U62 family.
CC {ECO:0000256|ARBA:ARBA00005836}.
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DR EMBL; AE003852; AAF93595.1; -; Genomic_DNA.
DR PIR; G82325; G82325.
DR RefSeq; NP_230076.1; NC_002505.1.
DR RefSeq; WP_000178532.1; NZ_LT906614.1.
DR AlphaFoldDB; Q9KUU3; -.
DR SMR; Q9KUU3; -.
DR STRING; 243277.VC_0422; -.
DR DNASU; 2615683; -.
DR EnsemblBacteria; AAF93595; AAF93595; VC_0422.
DR KEGG; vch:VC_0422; -.
DR PATRIC; fig|243277.26.peg.397; -.
DR eggNOG; COG0312; Bacteria.
DR HOGENOM; CLU_026425_1_0_6; -.
DR Proteomes; UP000000584; Chromosome 1.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR InterPro; IPR025502; TldD.
DR InterPro; IPR035068; TldD/PmbA_N.
DR InterPro; IPR036059; TldD/PmbA_sf.
DR PANTHER; PTHR30624:SF4; METALLOPROTEASE TLDD; 1.
DR PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR Pfam; PF01523; PmbA_TldD_1st; 1.
DR Pfam; PF19290; PmbA_TldD_2nd; 1.
DR Pfam; PF19289; PmbA_TldD_3rd; 1.
DR PIRSF; PIRSF004919; TldD; 1.
DR SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000000584}.
FT DOMAIN 36..100
FT /note="Metalloprotease TldD/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01523"
FT DOMAIN 125..238
FT /note="Metalloprotease TldD/E central"
FT /evidence="ECO:0000259|Pfam:PF19290"
FT DOMAIN 246..479
FT /note="Metalloprotease TldD/E C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19289"
SQ SEQUENCE 481 AA; 51204 MW; D5790AAA1B169A98 CRC64;
MTMNQIETAL LAPAGLTEQD IADTLSSIAT RQIDYADIYF QSSWHESLVL EDSIIKDGSF
NIDCGVGVRA VSGEKTGFAY SDQIQLEGLK QSAIAARGIA QQGQNLTVQA FKRAQHPAFY
GAHNPLESWE KQQKTELLKQ LDAYIRTKEP LITEVSVSLS GVHEQILVAA TDGTYAGDIR
PLVRLSISVL AQKGDRRERG SAGGGGRFGY DYFLQEEAGQ KIAFSFADEA IRQALVNLEA
VAAPAGTMPV VLGSGWPGVL LHEAVGHGLE GDFNRKGSSV FAGKVGKKVT SDLCTIVDDG
TLKDLRGSLN VDDEGVSGQY NVLIEKGILK GYIQDKLNAR LMGVAPTGNG RRESYAHLPM
PRMTNTYMLP GEHTPEEIIA SVKKGIYAPN FGGGQVDITS GKFVFSASEA YLIENGKITR
PIKGATLIGS GIEAMQQVSM VGNDLALDRG VGVCGKAGQS VPVGVGQPTL KLDALTVGGT
E
//
