ID Q9LCG8_LACPN Unreviewed; 440 AA.
AC Q9LCG8;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 136.
DE SubName: Full=Acetyl-CoA carboxylase {ECO:0000313|EMBL:APD00259.1, ECO:0000313|EMBL:ODO60653.1};
DE EC=6.3.4.14 {ECO:0000313|EMBL:ODO60653.1, ECO:0000313|EMBL:QHM36427.1};
DE SubName: Full=Biotin carboxylase {ECO:0000313|EMBL:BAA93643.1, ECO:0000313|EMBL:BBA81464.1};
DE EC=6.4.1.2 {ECO:0000313|EMBL:BBA81464.1, ECO:0000313|EMBL:ODO60653.1};
DE SubName: Full=Biotin carboxylase of acetyl-CoA carboxylase {ECO:0000313|EMBL:KZU94095.1};
GN Name=accC {ECO:0000313|EMBL:BAA93643.1};
GN Synonyms=accC1 {ECO:0000313|EMBL:BBA81464.1}, accC_1
GN {ECO:0000313|EMBL:QHM36427.1}, accC_2 {ECO:0000313|EMBL:QHM49603.1};
GN ORFNames=ASV54_02445 {ECO:0000313|EMBL:APD00259.1}, C7M36_00687
GN {ECO:0000313|EMBL:QHM36427.1}, C7M40_01558
GN {ECO:0000313|EMBL:QHM49603.1}, Lp19_2069
GN {ECO:0000313|EMBL:KZU94095.1}, LPJSA22_00597
GN {ECO:0000313|EMBL:ODO60653.1}, LpLQ80_02545
GN {ECO:0000313|EMBL:AWI39449.1}, SN35N_1085
GN {ECO:0000313|EMBL:BBA81464.1};
OS Lactiplantibacillus plantarum (Lactobacillus plantarum).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactiplantibacillus.
OX NCBI_TaxID=1590 {ECO:0000313|EMBL:BAA93643.1};
RN [1] {ECO:0000313|EMBL:BAA93643.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=L137 {ECO:0000313|EMBL:BAA93643.1};
RX PubMed=11133475; DOI=10.1128/AEM.67.1.426-433.2001;
RA Kiatpapan P., Kobayashi H., Sakaguchi M., Ono H., Yamashita M., Kaneko Y.,
RA Murooka Y.;
RT "Molecular characterization of Lactobacillus plantarum genes for beta-
RT ketoacyl-acyl carrier protein synthase III(fabH) and acetyl coenzyme A
RT carboxylase (accBCDA), which are essential for fatty acid biosynthesis.";
RL Appl. Environ. Microbiol. 67:426-433(2001).
RN [2] {ECO:0000313|Proteomes:UP000183026}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MF1298 {ECO:0000313|Proteomes:UP000183026};
RA McLeod A., Rud I., Axelsson L.;
RT "Genome sequence of Lactobacillus plantarum MF1298, a candidate probiotic
RT associated with unfavorable effect.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KZU94095.1, ECO:0000313|Proteomes:UP000076882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=19.1 {ECO:0000313|EMBL:KZU94095.1,
RC ECO:0000313|Proteomes:UP000076882};
RA Martino M.E.;
RT "Comparative genomics of 54 Lactobacillus plantarum strains reveals genomic
RT uncoupling from niche constraints.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ODO60653.1, ECO:0000313|Proteomes:UP000094892}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JSA22 {ECO:0000313|EMBL:ODO60653.1,
RC ECO:0000313|Proteomes:UP000094892};
RA Choi H.S.;
RT "Genome sequencing of Lactobacillus plantarum JSA22, isolated from
RT fermented soybean paste.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:BBA81464.1, ECO:0000313|Proteomes:UP000269784}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SN35N {ECO:0000313|EMBL:BBA81464.1,
RC ECO:0000313|Proteomes:UP000269784};
RX PubMed=29607926; DOI=.1248/bpb.b17-00840;
RA Noda M., Shiraga M., Kumagai T., Danshiitsoodol N., Sugiyama M.;
RT "Characterization of the SN35N Strain-Specific Exopolysaccharide Encoded in
RT the Whole Circular Genome of a Plant-Derived Lactobacillus plantarum.";
RL Biol. Pharm. Bull. 41:536-545(2018).
RN [6] {ECO:0000313|EMBL:QHM36427.1, ECO:0000313|Proteomes:UP000464882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRCM101167 {ECO:0000313|EMBL:QHM36427.1,
RC ECO:0000313|Proteomes:UP000464882};
RA Jeong D.-Y.;
RT "Lactobacillus plantatrum SRCM101167 having anti-virus activity species
RT isolated from Korea kimchi.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:QHM49603.1, ECO:0000313|Proteomes:UP000465032}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRCM101518 {ECO:0000313|EMBL:QHM49603.1,
RC ECO:0000313|Proteomes:UP000465032};
RA Jeong D.-Y.;
RT "Lactobacillus plantatrum SRCM101518 having antimicrbial activity species
RT isolated from Korea kimchi.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:AWI39449.1, ECO:0000313|Proteomes:UP000244922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LQ80 {ECO:0000313|EMBL:AWI39449.1,
RC ECO:0000313|Proteomes:UP000244922};
RA Moriya N., Nakano K., Shiroma A., Shinzato M., Ashimine N., Minami M.,
RA Tamotsu H., Shimoji M., Nakanishi T., Ohki S., Teruya K., Satou K.,
RA Hirano T., Hagi T., Kobayashi M., Nomura M., Kimoto H.N., Tajima K.,
RA Cai Y., Suzuki C.;
RT "Complete Genome Sequence of Lactobacillus plantarum Strain LQ80 Selected
RT for Preparation of Fermented Liquid Feed for Pig.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:APD00259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MF1298 {ECO:0000313|EMBL:APD00259.1};
RA McLeod A., Fagerlund A., Rud I., Axelsson L.;
RT "Genome sequence of Lactobacillus plantarum MF1298, a candidate probiotic
RT associated with unfavorable effect.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR EMBL; CP013149; APD00259.1; -; Genomic_DNA.
DR EMBL; CP028977; AWI39449.1; -; Genomic_DNA.
DR EMBL; AB025973; BAA93643.1; -; Genomic_DNA.
DR EMBL; AP018405; BBA81464.1; -; Genomic_DNA.
DR EMBL; LUXM01000033; KZU94095.1; -; Genomic_DNA.
DR EMBL; MCOL01000001; ODO60653.1; -; Genomic_DNA.
DR EMBL; CP028334; QHM36427.1; -; Genomic_DNA.
DR EMBL; CP028241; QHM49603.1; -; Genomic_DNA.
DR RefSeq; WP_015379847.1; NZ_WWDG01000013.1.
DR KEGG; lpb:SH83_02575; -.
DR PATRIC; fig|1590.144.peg.536; -.
DR Proteomes; UP000076882; Unassembled WGS sequence.
DR Proteomes; UP000094892; Unassembled WGS sequence.
DR Proteomes; UP000183026; Chromosome.
DR Proteomes; UP000244922; Chromosome.
DR Proteomes; UP000269784; Chromosome.
DR Proteomes; UP000464882; Chromosome.
DR Proteomes; UP000465032; Chromosome.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004075; F:biotin carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR18866:SF33; METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:BBA81464.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}.
FT DOMAIN 1..438
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 120..315
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
SQ SEQUENCE 440 AA; 48264 MW; 28A000C01223E8B1 CRC64;
MFRKLLIANR GEIAVRIIKA CQQLNIQTVA VCSTADRHAG YTQLADEVVC IGPAAASGSY
LNAEAILMAA INTHADAIHP GYGFLAENAD FAAMCAECGI AWIGPQTEQI KLMGDKARAK
DFARQQAVPV LAGQSLQGLA WPDIKHAAAK IGFPLVLKAS YGGGGKGIRV LTDVHELHQQ
LRAARQEAAA SFLNDAMYLE QFLTTARHIE VQVLGTGTKL FILGDRDCSL QLHKQKVLEE
SPASILTETQ RRTLYDLSRQ LLAGTHYQSL GTIEYLFADG QFYFMEMNTR LQVEHGVTEL
TTGIDIVAEQ IKQAAGVTVD FPEHVGLQPK CTAIEARLTA TLPVKQTRIE TLSWPADVRV
DTDYHQGDRL VTMYDGLIAK LMVTGANRQQ AVRNLQRALA QVTLTGPTTN LTFLQQTVAR
PAYIHDQYTI HSLARWEASK
//
