ID Q9LLI2_MAIZE Unreviewed; 1094 AA.
AC Q9LLI2;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 149.
DE RecName: Full=Cellulose synthase {ECO:0000256|RuleBase:RU361116};
DE EC=2.4.1.12 {ECO:0000256|RuleBase:RU361116};
GN Name=CesA-8 {ECO:0000313|EMBL:AAF89968.1};
GN Synonyms=541806 {ECO:0000313|EnsemblPlants:Zm00001eb304560_P002};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577 {ECO:0000313|EMBL:AAF89968.1};
RN [1] {ECO:0000313|EMBL:AAF89968.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10938350; DOI=10.1104/pp.123.4.1313;
RA Holland N., Holland D., Helentjaris T., Dhugga K.S., Xoconostle-Cazares B.,
RA Delmer D.P.;
RT "A comparative analysis of the plant cellulose synthase (CesA) gene
RT family.";
RL Plant Physiol. 123:1313-1324(2000).
RN [2] {ECO:0000313|EnsemblPlants:Zm00001eb304560_P002, ECO:0000313|Proteomes:UP000007305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001eb304560_P002,
RC ECO:0000313|Proteomes:UP000007305};
RG Maize Genome Sequencing Project;
RA Ware D.;
RT "Update maize B73 reference genome by single molecule sequencing
RT technologies.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:Zm00001eb304560_P002}
RP IDENTIFICATION.
RC STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001eb304560_P002};
RG EnsemblPlants;
RL Submitted (MAY-2021) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-
CC beta-D-glucosyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:19929, Rhea:RHEA-
CC COMP:10033, Rhea:RHEA-COMP:10034, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:18246, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.12;
CC Evidence={ECO:0000256|ARBA:ARBA00000122,
CC ECO:0000256|RuleBase:RU361116};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361116};
CC Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000256|RuleBase:RU361116};
CC -!- PATHWAY: Glycan metabolism; plant cellulose biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004768, ECO:0000256|RuleBase:RU361116}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361116}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361116}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. Plant
CC cellulose synthase subfamily. {ECO:0000256|ARBA:ARBA00007548,
CC ECO:0000256|RuleBase:RU361116}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF200532; AAF89968.1; -; mRNA.
DR RefSeq; NP_001104958.1; NM_001111488.2.
DR AlphaFoldDB; Q9LLI2; -.
DR CAZy; GT2; Glycosyltransferase Family 2.
DR EnsemblPlants; Zm00001eb304560_T002; Zm00001eb304560_P002; Zm00001eb304560.
DR GeneID; 541806; -.
DR Gramene; Zm00001eb304560_T002; Zm00001eb304560_P002; Zm00001eb304560.
DR KEGG; zma:541806; -.
DR HOGENOM; CLU_001418_0_2_1; -.
DR InParanoid; Q9LLI2; -.
DR OrthoDB; 1210919at2759; -.
DR UniPathway; UPA00695; -.
DR Proteomes; UP000007305; Chromosome 7.
DR ExpressionAtlas; Q9LLI2; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016760; F:cellulose synthase (UDP-forming) activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0030244; P:cellulose biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0071669; P:plant-type cell wall organization or biogenesis; IEA:UniProt.
DR CDD; cd16617; mRING-HC-C4C4_CesA; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR005150; Cellulose_synth.
DR InterPro; IPR027934; CES_Znf_RING.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13301:SF255; CELLULOSE SYNTHASE A CATALYTIC SUBUNIT 6 [UDP-FORMING]-RELATED; 1.
DR PANTHER; PTHR13301; X-BOX TRANSCRIPTION FACTOR-RELATED; 1.
DR Pfam; PF03552; Cellulose_synt; 1.
DR Pfam; PF14569; zf-UDP; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU361116};
KW Cell wall biogenesis/degradation {ECO:0000256|RuleBase:RU361116};
KW Cellulose biosynthesis {ECO:0000256|ARBA:ARBA00022916,
KW ECO:0000256|RuleBase:RU361116};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU361116}; Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361116};
KW Metal-binding {ECO:0000256|RuleBase:RU361116};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q9LLI2};
KW Reference proteome {ECO:0000313|Proteomes:UP000007305};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361116};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361116};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361116};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361116};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 277..295
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361116"
FT TRANSMEM 307..326
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361116"
FT TRANSMEM 872..892
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361116"
FT TRANSMEM 904..922
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361116"
FT TRANSMEM 942..962
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361116"
FT TRANSMEM 991..1014
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361116"
FT TRANSMEM 1020..1042
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361116"
FT TRANSMEM 1054..1074
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361116"
FT DOMAIN 41..87
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 1094 AA; 122576 MW; DFBBC18F49D23F5E CRC64;
MEASAGLVAG SHNRNELVVI RRDRESGAAG GGAARRAEAP CQICGDEVGV GFDGEPFVAC
NECAFPVCRA CYEYERREGS QACPQCRTRY KRLKGCPRVA GDEEEDGVDD LEGEFGLQDG
AAHEDDPQYV AESMLRAQMS YGRGGDAHPG FSPVPNVPLL TNGQMVDDIP PEQHALVPSY
MSGGGGGGKR IHPLPFADPN LPVQPRSMDP SKDLAAYGYG SVAWKERMEG WKQKQERLQH
VRSEGGGDWD GDDADLPLMD EARQPLSRKV PISSSRINPY RMIIVIRLVV LGFFFHYRVM
HPAKDAFALW LISVICEIWF AMSWILDQFP KWLPIERETY LDRLSLRFDK EGQPSQLAPI
DFFVSTVDPT KEPPLVTANT VLSILSVDYP VEKVSCYVSD DGAAMLTFEA LSETSEFAKK
WVPFSKKFNI EPRAPEWYFQ QKIDYLKDKV AASFVRERRA MKREYEEFKV RINALVAKAQ
KVPEEGWTMQ DGSPWPGNNV RDHPGMIQVF LGQSGGRDVE GNELPRLVYV SREKRPGYNH
HKKAGAMNAL VRVSAVLSNA AYLLNLDCDH YINNSKAIKE AMCFMMDPLV GKKVCYVQFP
QRFDGIDKND RYANRNVVFF DINMKGLDGI QGPIYVGTGC VFRRQALYGY DAPKTKKPPS
RTCNCWPKWC LSCCCSRNKN KKKTTKPKTE KKKRLFFKKA ENPSPAYALG EIDEGAPGAD
IEKAGIVNQQ KLEKKFGQSS VFVASTLLEN GGTLKSASPA SLLKEAIHVI SCGYEDKTDW
GKEIGWIYGS ITEDILTGFK MHCHGWRSIY CIPKRPAFKG SAPLNLSDRL HQVLRWALGS
VEIFFSKHCP LWYGYGGGLK FLERFSYINS IVYPWTSIPL LAYCTLPAIC LLTGKFITPE
LTNVASIWFM ALFICISVTG ILEMRWSGVA IDDWWRNEQF WVIGGVSAHL FAVFQGLLKV
FAGIDTSFTV TSKAGDDEEF SELYTFKWTT LLIPPTTLLL LNFIGVVAGI SNAINNGYES
WGPLFGKLFF AFWVIVHLYP FLKGLVGRQN RTPTIVIVWS ILLASIFSLL WVRVDPFLAK
SNGPLLEECG LDCN
//
