ID Q9M0Q5_ARATH Unreviewed; 853 AA.
AC Q9M0Q5;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 160.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN OrderedLocusNames=At4g09360 {ECO:0000313|Araport:AT4G09360,
GN ECO:0000313|EMBL:CAB78059.1};
GN ORFNames=T15G18.1 {ECO:0000313|EMBL:AEE82745.1}, T15G18_1
GN {ECO:0000313|EMBL:AEE82745.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:CAB78059.1};
RN [1] {ECO:0000313|EMBL:AEE82745.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=10617198; DOI=10.1038/47134;
RG EU;
RG CSHL and WU Arabidopsis Sequencing Project;
RA Mayer K., Schuller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Dusterhoft A., Stiekema W., Entian K.D., Terryn N., Harris B., Ansorge W.,
RA Brandt P., Grivell L., Rieger M., Weichselgartner M., de Simone V.,
RA Obermaier B., Mache R., Muller M., Kreis M., Delseny M., Puigdomenech P.,
RA Watson M., Schmidtheini T., Reichert B., Portatelle D., Perez-Alonso M.,
RA Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H.,
RA Ridley P., Langham S.A., McCullagh B., Bilham L., Robben J.,
RA Van der Schueren J., Grymonprez B., Chuang Y.J., Vandenbussche F.,
RA Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E.,
RA Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E.,
RA Brandt A., Peters S., van Staveren M., Dirske W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Kotter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., Van Montagu M., Rogers J.,
RA Cronin A., Quail M., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M.,
RA Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M.,
RA Benes V., Rechmann S., Borkova D., Blocker H., Scharfe M., Grimm M.,
RA Lohnert T.H., Dose S., de Haan M., Maarse A., Schafer M., Muller-Auer S.,
RA Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A.,
RA Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O.,
RA Quigley F., Clabauld G., Mundlein A., Felber R., Schnabl S., Hiller R.,
RA Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C.,
RA Montfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sehkon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L., Nelson J.,
RA Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J.,
RA Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffmann J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2] {ECO:0000313|EMBL:CAB78059.1}
RP NUCLEOTIDE SEQUENCE.
RA Spiegel L.A., Huang E.N., Nascimento L.U., de la Bastide M., Vil D.M.,
RA Preston R.R., Matero A., Shah R., O'Shaughnessy A., Rodriguez M.,
RA Shekher M., Schutz K., See L.H., Swaby I., Habermann K., Dedhia N.N.,
RA Mewes H.W., Lemcke K., Mayer K.F.X.;
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CAB78059.1}
RP NUCLEOTIDE SEQUENCE.
RA EU Arabidopsis sequencing project;
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0007829|PubMed:17272265}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17272265; DOI=10.1074/mcp.M600408-MCP200;
RA Maor R., Jones A., Nuhse T.S., Studholme D.J., Peck S.C., Shirasu K.;
RT "Multidimensional protein identification technology (MudPIT) analysis of
RT ubiquitinated proteins in plants.";
RL Mol. Cell. Proteomics 6:601-610(2007).
RN [5] {ECO:0000313|EMBL:AEE82745.1}
RP NUCLEOTIDE SEQUENCE.
RG TAIR;
RA Swarbreck D., Lamesch P., Wilks C., Huala E.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:AEE82745.1}
RP NUCLEOTIDE SEQUENCE.
RA Krishnakumar V., Cheng C.-Y., Chan A.P., Schobel S., Kim M., Ferlanti E.S.,
RA Belyaeva I., Rosen B.D., Micklem G., Miller J.R., Vaughn M., Town C.D.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; CP002687; AEE82745.1; -; Genomic_DNA.
DR EMBL; AL161514; CAB78059.1; -; Genomic_DNA.
DR PIR; B85095; B85095.
DR RefSeq; NP_192674.1; NM_117004.1.
DR AlphaFoldDB; Q9M0Q5; -.
DR SMR; Q9M0Q5; -.
DR STRING; 3702.Q9M0Q5; -.
DR PaxDb; 3702-AT4G09360-1; -.
DR EnsemblPlants; AT4G09360.1; AT4G09360.1; AT4G09360.
DR GeneID; 826518; -.
DR Gramene; AT4G09360.1; AT4G09360.1; AT4G09360.
DR KEGG; ath:AT4G09360; -.
DR Araport; AT4G09360; -.
DR TAIR; AT4G09360; -.
DR HOGENOM; CLU_001561_0_2_1; -.
DR OMA; CILISCE; -.
DR OrthoDB; 687499at2759; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9M0Q5; baseline and differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF511; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 1: Evidence at protein level;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548}.
FT DOMAIN 19..154
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 853 AA; 96663 MW; 4D976466C99B5D03 CRC64;
MDVDMERLNP LLSIESENEV RMIGIWGMGG IGKTTIAKCL YEEYSRRFVH YCFIENVRIF
AKNGLPYLQE KLLSEIRGKK QETLWSVEKG CRLIKSKLKE KNFLVLDDVD NVDQLHALAK
ETSWFGPGSR IIITTRDFGL LYSFGVRLLY RVSFLDDNDA IKVFKHVAFD GGQPPFDVYH
QFSVRASRLA QGLPSALEAF GALGILETVP QKRIKDILKT SYDGLDEEEQ AAFLHVACLF
NGDSVHRVNA LIDDGDMRIK ALEVKSLIDI SLDGCITLHV LIEQAAREID TAMVEGVALH
MCEMIHVLPI DGNILNTINN LKFFKAFTHI EVMNSKLQFL PGTANNSGGL GQLRRLDVTG
SKNLREIPDL SRTMLLEELI MKGCTRLEKT LDIRKGCPSR TWTKATPTNN IEASQRSKEA
EFSCKPIYRR EDTHRLVASH GNRRAPLLYS EQKIPDELVM VPKKRFPIIS SFYDLKSLSI
MRFSHIADGT PFRCISFSGF QCLVELNLIN LNIQKIPDNI GLMQSLEKVD LSGNDFRNLP
ASTKNLSKLK YARLSNCIKL EAFVELTELQ TLKLSGCTNL ESLLELPYAV QDVGRFCLLA
LELDNCKNLQ ALSEQLSHFS NLIHLDLSSH DFEKLKSVEE LPLNLKHLYA HGCDSLESVD
LSPKHSIKHL DLSHCFGLQQ DEQQITQFLN DKCSQEVSQR FLCLPGTEVP RNFDNQSHGT
STKISLFTPT LLSFAACILI SCERSFYLQF PAFSYDWNRK DDEVISINLT PNLNLSSEIE
EEETVTSHHL VIIHVPSSIN TDKIEDLRLE SSLQFPEEFQ FSPCEIRACG IRMVDEETKC
LESSPLMPLL EKK
//
