ID Q9N452_CAEEL Unreviewed; 326 AA.
AC Q9N452;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 2.
DT 27-MAR-2024, entry version 132.
DE SubName: Full=G-protein coupled receptors family 1 profile domain-containing protein {ECO:0000313|EMBL:CCD68050.1};
GN Name=npr-23 {ECO:0000313|EMBL:CCD68050.1,
GN ECO:0000313|WormBase:Y34D9A.2};
GN ORFNames=CELE_Y34D9A.2 {ECO:0000313|EMBL:CCD68050.1}, Y34D9A.2
GN {ECO:0000313|WormBase:Y34D9A.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD68050.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD68050.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD68050.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; BX284601; CCD68050.1; -; Genomic_DNA.
DR RefSeq; NP_490815.2; NM_058414.4.
DR AlphaFoldDB; Q9N452; -.
DR SMR; Q9N452; -.
DR STRING; 6239.Y34D9A.2.1; -.
DR PaxDb; 6239-Y34D9A-2; -.
DR EnsemblMetazoa; Y34D9A.2.1; Y34D9A.2.1; WBGene00021328.
DR GeneID; 189587; -.
DR KEGG; cel:CELE_Y34D9A.2; -.
DR UCSC; Y34D9A.2; c. elegans.
DR AGR; WB:WBGene00021328; -.
DR WormBase; Y34D9A.2; CE30217; WBGene00021328; npr-23.
DR eggNOG; ENOG502SMHI; Eukaryota.
DR HOGENOM; CLU_886529_0_0_1; -.
DR InParanoid; Q9N452; -.
DR OMA; LSWIISW; -.
DR OrthoDB; 2875538at2759; -.
DR Reactome; R-CEL-202040; G-protein activation.
DR Reactome; R-CEL-391908; Prostanoid ligand receptors.
DR Reactome; R-CEL-416476; G alpha (q) signalling events.
DR Reactome; R-CEL-418594; G alpha (i) signalling events.
DR Reactome; R-CEL-5620922; BBSome-mediated cargo-targeting to cilium.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00021328; Expressed in larva and 3 other cell types or tissues.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR CDD; cd00637; 7tm_classA_rhodopsin-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24228; B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR; 1.
DR PANTHER; PTHR24228:SF72; G-PROTEIN COUPLED RECEPTOR MOODY; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:CCD68050.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..285
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 326 AA; 36561 MW; 65E1D199D6510A44 CRC64;
MYGFFNSSEI DEEYYNSTHT SAPSPILALI FTIICIIGVI GNASLLVYIF AKKLYQNFIS
SRFIGHLCFT NLIALLVLVP VIIHNVFTGV NLLQDSNMLC RIQVSITVTV WTVIAMMNLC
IAGVHLLTFA RIHYEQLFGL TPTKLCILSW IISWLLSLPS LTNGHVAIYG PAVRTCVFSH
SDSGLKFLTY TMIFGVFIPA LFSSIAYFRI LQTLFHSPIV FQSLGLYKSR FLVYFFLLGP
LYALPFYILT ALDPSDPVRM SQDTLWTIGC TMFAFVPCII APLLYGASIF IIKEEDMALT
ARTHTKTGTG AYHHVAHQHN MQAQLI
//
