ID Q9N592_CAEEL Unreviewed; 504 AA.
AC Q9N592;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 139.
DE RecName: Full=U4/U6 small nuclear ribonucleoprotein Prp31 {ECO:0000256|ARBA:ARBA00013538};
DE AltName: Full=Pre-mRNA-processing factor 31 {ECO:0000256|ARBA:ARBA00030766};
GN Name=prp-31 {ECO:0000313|EMBL:CCD66198.1,
GN ECO:0000313|WormBase:Y110A7A.8};
GN ORFNames=CELE_Y110A7A.8 {ECO:0000313|EMBL:CCD66198.1}, Y110A7A.8
GN {ECO:0000313|WormBase:Y110A7A.8};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD66198.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD66198.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD66198.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PRP31 family.
CC {ECO:0000256|ARBA:ARBA00005572}.
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DR EMBL; BX284601; CCD66198.1; -; Genomic_DNA.
DR RefSeq; NP_491527.1; NM_059126.5.
DR AlphaFoldDB; Q9N592; -.
DR SMR; Q9N592; -.
DR STRING; 6239.Y110A7A.8.1; -.
DR EPD; Q9N592; -.
DR PaxDb; 6239-Y110A7A-8; -.
DR PeptideAtlas; Q9N592; -.
DR EnsemblMetazoa; Y110A7A.8.1; Y110A7A.8.1; WBGene00022458.
DR GeneID; 172146; -.
DR KEGG; cel:CELE_Y110A7A.8; -.
DR UCSC; Y110A7A.8.2; c. elegans.
DR AGR; WB:WBGene00022458; -.
DR WormBase; Y110A7A.8; CE24126; WBGene00022458; prp-31.
DR eggNOG; KOG2574; Eukaryota.
DR GeneTree; ENSGT00550000075069; -.
DR HOGENOM; CLU_026337_2_0_1; -.
DR InParanoid; Q9N592; -.
DR OMA; IGNGPMD; -.
DR OrthoDB; 4493115at2759; -.
DR PhylomeDB; Q9N592; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00022458; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR GO; GO:0097526; C:spliceosomal tri-snRNP complex; IBA:GO_Central.
DR GO; GO:0005687; C:U4 snRNP; IBA:GO_Central.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IEA:InterPro.
DR Gene3D; 1.10.287.4070; -; 1.
DR Gene3D; 1.10.246.90; Nop domain; 1.
DR InterPro; IPR042239; Nop_C.
DR InterPro; IPR002687; Nop_dom.
DR InterPro; IPR036070; Nop_dom_sf.
DR InterPro; IPR012976; NOSIC.
DR InterPro; IPR027105; Prp31.
DR InterPro; IPR019175; Prp31_C.
DR PANTHER; PTHR13904; PRE-MRNA SPLICING FACTOR PRP31; 1.
DR PANTHER; PTHR13904:SF0; U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31; 1.
DR Pfam; PF01798; Nop; 1.
DR Pfam; PF09785; Prp31_C; 1.
DR SMART; SM00931; NOSIC; 1.
DR SUPFAM; SSF89124; Nop domain; 1.
DR PROSITE; PS51358; NOP; 1.
PE 1: Evidence at protein level;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|EPD:Q9N592,
KW ECO:0007829|PeptideAtlas:Q9N592};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW ECO:0000313|EMBL:CCD66198.1}; RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 224..342
FT /note="Nop"
FT /evidence="ECO:0000259|PROSITE:PS51358"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..23
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 504 AA; 55618 MW; B87329A503748210 CRC64;
MSLAEELMAD FDDDDDEDLE DIPDLGENLK GVKKEELDDD IEEATEEPMD TTKYASVHDV
AKLARSDEYL ALVKQLEVEL KRPQDEVKVT APLEADPQYK LIVKLSHVAA DIDNEINVIH
KFVRDKYEKR FPELETLVPN ALTYLATVQL LGNEINSKVV KEQLGGILDA STCMVVSVTV
STTQGVKLEP NELETVMDAC NLAAQLHVNR LEMHQLVEWR MALIAPNLVA LLGSTTTAHL
VSQAGGLSPL ATMPSCNVQV LGKTKKNLIG FSTVSTNPHH GFIYFHQLVQ KMPPDLKNKA
AKILAAKVTL VARIDAQHES SNGEKGAEFL ALVESKFEKM LEPPPVKANK ALPKPLDKAS
KKRGGRRTRK MKERLGMTDL RKSANRMNFG ELGEDVMQEH MGFDIGQVKT GNVTGGRIRT
AAVDQKTRAR MSQKMMRQME RQKAAGGMTS IRSKMAGTAS SVTFTPIQGL EIINPAAQEQ
QQCSSTSNYF SSSGSFVNID RMTL
//
