ID Q9N6U0_LEPDE Unreviewed; 955 AA.
AC Q9N6U0;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE RecName: Full=protein-synthesizing GTPase {ECO:0000256|ARBA:ARBA00011986};
DE EC=3.6.5.3 {ECO:0000256|ARBA:ARBA00011986};
DE Flags: Fragment;
GN Name=Su(var)3-9 {ECO:0000313|EMBL:CAB94835.1};
OS Leptinotarsa decemlineata (Colorado potato beetle) (Doryphora
OS decemlineata).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Chrysomeloidea; Chrysomelidae; Chrysomelinae; Doryphorini; Leptinotarsa.
OX NCBI_TaxID=7539 {ECO:0000313|EMBL:CAB94835.1};
RN [1] {ECO:0000313|EMBL:CAB94835.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11063691;
RA Krauss V., Reuter G.;
RT "Two genes become one: the genes encoding heterochromatin protein Su(var)3-
RT 9 and translation initiation factor subunit eIF-2gamma are joined to a
RT dicistronic unit in holometabolic insects.";
RL Genetics 156:1157-1167(2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.3;
CC Evidence={ECO:0000256|ARBA:ARBA00001874};
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere
CC {ECO:0000256|ARBA:ARBA00004584}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AJ290965; CAB94835.1; -; mRNA.
DR AlphaFoldDB; Q9N6U0; -.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00024; CD_CSD; 1.
DR CDD; cd01888; eIF2_gamma; 1.
DR CDD; cd03688; eIF2_gamma_II; 1.
DR CDD; cd15490; eIF2_gamma_III; 1.
DR CDD; cd10542; SET_SUV39H; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015256; eIF2g_C.
DR InterPro; IPR044127; eIF2g_dom_2.
DR InterPro; IPR044128; eIF2g_GTP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR PANTHER; PTHR42854; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER; 1.
DR PANTHER; PTHR42854:SF3; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF09173; eIF2_C; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00298; CHROMO; 1.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF82199; SET domain; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS51722; G_TR_2; 1.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 2: Evidence at transcript level;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 149..210
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 339..399
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 402..527
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 613..732
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT COILED 100..127
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 955
FT /evidence="ECO:0000313|EMBL:CAB94835.1"
SQ SEQUENCE 955 AA; 106623 MW; A041F6F4E03B2DA0 CRC64;
MASTDVAGVT TGQPNLHKQD LSKLDVTKLT ALSPEVISRQ ATINIGTIGH VAHGKSTVVK
AISGVQTVRF KNELERNITI KLEKLQFDGN GSIITWPKQL KGKKVSLKRA LEDCENFEEE
RKGIKRKYEP SKIRKLRPNK ANATYKKEFV VEKILAQEFD VSTKQFMFLV KWKGYSMVHN
TWEPLEHLTH CSLLLTQFLA ESLGSQVLDA LCDKLNISNK LSEQNLLDML KIDNLDNIPD
KLHLQEKLLR VVATPPKERH IHKLEEGKKA ILMYQLLLKR ETQLKKLKSW EEMINTMAKE
EAAITIENKV DLECPPEGFT YINEYVATEG IDIPVEPTSG CDCEECGPKI KNCCGKQPHN
GFTFKARGRI NVNPGIAVYE CNKKCKCDEN CRNRVVQNGR KVPLCIFRTA NGCGWGVKAM
RKIHCGEFVC EYVGEVITHE EAEIRGRTYD EEGRTYLFDL DYNSKDNPYT VDAAKFGNVS
HFINHSCDPN LGVYAVWINC SDPNLPKLAL FALREIERYE EITFDYMMNI DPVVPTTPEK
SRFLHTPDKN QVIQNGRSIC KCEADSCYAN AKIYHCDNPK CPRPVCFTSG SSSKDDNFPC
TRQSCTGRFQ LVRHVSFVDC PGHDILMATM LNGAAVMDAA LLLIAGNESC PQPQTSEHLA
AIEIMKLKHI IILQNKIDLV KEGQAKEQQE QIVKFVQGTV AEGAPIIPIS AQLKYNTEVL
CEYIIKKIPV PLRDFTSEPR LIVIRSFDVN KPGCEVNDLK GGVAGGSILR GVLRVGQEIE
VRPGLVSKDP EGKLTCRPIF SRIVSLFAEQ NELQFAVPGG LIGVGTKIEP TLCRADRLVG
QVLGAVGALP SIFIELEVSY YLLKRLLGVR TEGDKKGAKV QRLTKSEVLL VNIGSLSTGG
RVAATKADLC KIALTNPVCT EVGEKIALSR RVEKHWRLIG WGHIRGGETI EPSNN
//
