ID Q9NIR9_LEIDO Unreviewed; 625 AA.
AC Q9NIR9;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Peroxisomal targeting signal-1 receptor {ECO:0000313|EMBL:AAF67841.1};
DE SubName: Full=Peroxisome_targeting_signal_1_receptor_putative/G eneDB:LmjF.35.1420 {ECO:0000313|EMBL:CAC5434165.1};
DE SubName: Full=TPR repeat family protein {ECO:0000313|EMBL:TPP46405.1};
GN Name=PEX5 {ECO:0000313|EMBL:AAF67841.1};
GN ORFNames=CGC20_0315 {ECO:0000313|EMBL:TPP46405.1}, LDHU3_35.1870
GN {ECO:0000313|EMBL:CAC5434165.1};
OS Leishmania donovani.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5661 {ECO:0000313|EMBL:AAF67841.1};
RN [1] {ECO:0000313|EMBL:AAF67841.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DI700 {ECO:0000313|EMBL:AAF67841.1};
RX PubMed=10788481; DOI=10.1074/jbc.275.18.13637;
RA Jardim A., Liu W., Zheleznova E., Ullman B.;
RT "Peroxisomal targeting signal-1 receptor protein PEX5 from Leishmania
RT donovani. Molecular, biochemical, and immunocytochemical
RT characterization.";
RL J. Biol. Chem. 275:13637-13644(2000).
RN [2] {ECO:0000313|EMBL:TPP46405.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FDAARGOS_360 {ECO:0000313|EMBL:TPP46405.1};
RA Duncan R., Fisher C., Tallon L.J., Sadzewicz L., Sengamalay N., Ott S.,
RA Godinez A., Nagaraj S., Nadendla S., Sichtig H.;
RT "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
RT Supporting development and validation of Infectious Disease Dx tests.";
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000318821}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FDAARGOS_360 {ECO:0000313|Proteomes:UP000318821};
RA Duncan R., Fisher C., Tallon L., Sadzewicz L., Sengamalay N., Ott S.,
RA Godinez A., Nagaraj S., Vavikolanu K., Vyas G., Nadendla S.,
RA Aluvathingal J., Sichtig H.;
RT "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
RT Supporting development and validation of Infectious Disease Dx tests.";
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CAC5434165.1}
RP NUCLEOTIDE SEQUENCE.
RA Camacho E., Gonzalez-de la Fuente S., Rastrojo A., Peiro-Pastor R.,
RA Solana JC., Tabera L., Gamarro F., Carrasco-Ramiro F., Requena JM.,
RA Aguado B.;
RL Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peroxisomal targeting signal receptor
CC family. {ECO:0000256|ARBA:ARBA00005348}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF198051; AAF67841.1; -; Genomic_DNA.
DR EMBL; LR812655; CAC5434165.1; -; Genomic_DNA.
DR EMBL; RHLD01000029; TPP46405.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9NIR9; -.
DR SMR; Q9NIR9; -.
DR VEuPathDB; TriTrypDB:LdBPK_351430.1; -.
DR VEuPathDB; TriTrypDB:LdCL_350019200; -.
DR VEuPathDB; TriTrypDB:LDHU3_35.1870; -.
DR Proteomes; UP000318821; Unassembled WGS sequence.
DR Proteomes; UP000601710; Chromosome 35.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR024111; PEX5/PEX5L.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR10130:SF0; GH08708P; 1.
DR PANTHER; PTHR10130; PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5; 1.
DR Pfam; PF13432; TPR_16; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Receptor {ECO:0000313|EMBL:AAF67841.1};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 471..504
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 505..538
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT COILED 283..310
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 625 AA; 69691 MW; ABED68CFAA3BB314 CRC64;
MDCNTGMQLG QQFSKDATMM HGGVPMSGAM SEQDALMVGA QVAGANPMMA AQWAQNFQQQ
QAMQAMRQQH EMEQAFQNSQ QQQAAAAQSR QMLGMAGPQQ QQFMAQQQQA SMMNAAMMSQ
GMMAANMGLG MMMPRTQYQP LPNLSALQPK QQQPLANLAP AAQDSAWADQ LSQQQWSTDY
SQVQTFSAPG MEDKTVEERI KDSEFYKFMD QVKNKEVLID EEKGELVQGP GPEVGVPEDA
EYLRHWAEME GLHMPESVFQ SPPPASAMTS PENGDPDAYV KEMDMAANDV EDWAQEYAEM
QERLQKVTNS TDYPFEPNNP YMFHDFPFDE GMEMLQLGNL AEAALAFEAV CHKDSSNEKA
WQILGTTQAE NEKDGLAIIA LNNARKLNPR NLEVHAALSV SHTNERNADA AMDSLKAWLI
NHPEYEQLAS VSIPPNAELD VQETFFFADP SRMREARTLY EAAIEMNPSD SQLFTNLGVL
HNVAHEFDEA AECFRKAVAL HPDDPKMWNK LGATLANGGH PDQALEAYNR ALDINPGYVR
AMYNMAVAYS NMSQYNMAAR QIVKAIASQQ GGTKPSGEGS IMATRNMWDL LRMTLNLMDR
DDLVQLTYNE QLEPFVKEFG LEGHV
//
