ID Q9R3A9_ECOLX Unreviewed; 262 AA.
AC Q9R3A9;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 177.
DE RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252};
DE EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126};
GN Name=aadA5 {ECO:0000313|EMBL:AAF17880.1};
GN Synonyms=aadA {ECO:0000313|EMBL:ACQ42057.1}, aadA4
GN {ECO:0000313|EMBL:AAT37605.1}, aada5 {ECO:0000313|EMBL:AAV69850.1},
GN ant1 {ECO:0000313|EMBL:AKN35618.1};
GN ORFNames=C0P57_004907 {ECO:0000313|EMBL:EFB4535520.1}, C0P57_005478
GN {ECO:0000313|EMBL:EFB4536040.1}, EIA08_28800
GN {ECO:0000313|EMBL:RRD68299.1}, EIMP300_90630
GN {ECO:0000313|EMBL:BBU87663.1}, EIZ93_24720
GN {ECO:0000313|EMBL:MQK27398.1}, F7N46_18445
GN {ECO:0000313|EMBL:EFE8675069.1}, F7N46_27205
GN {ECO:0000313|EMBL:EFE8676688.1}, GRC73_23680
GN {ECO:0000313|EMBL:HAH4526954.1}, HMV95_21520
GN {ECO:0000313|EMBL:HAJ5960808.1}, HMV95_26385
GN {ECO:0000313|EMBL:HAJ5961692.1}, I4I37_26990
GN {ECO:0000313|EMBL:MBF9179898.1}, O2R_115
GN {ECO:0000313|EMBL:AAT37605.1}, pESCR_00112
GN {ECO:0000313|EMBL:AKN35618.1}, RCS76_PI0007
GN {ECO:0000313|EMBL:SPE02109.1};
OS Escherichia coli.
OG Plasmid RCS76_pI {ECO:0000313|EMBL:SPE02109.1},
OG Plasmid pAPEC-O2-R {ECO:0000313|EMBL:AAT37605.1},
OG Plasmid pC49-108 {ECO:0000313|EMBL:AIF79063.1},
OG Plasmid pCA14 {ECO:0000313|EMBL:AKD26486.1},
OG Plasmid pEK499 {ECO:0000313|EMBL:ACQ42057.1},
OG Plasmid pESBL-305 {ECO:0000313|EMBL:AIG72713.1},
OG Plasmid pESCR {ECO:0000313|EMBL:AKN35618.1},
OG Plasmid pHV114 {ECO:0000313|EMBL:AJM90859.1},
OG Plasmid pJIE118 {ECO:0000313|EMBL:AER36615.1},
OG Plasmid pYDC637 {ECO:0000313|EMBL:AIY22993.1},
OG Plasmid rcs76_pi {ECO:0000313|Proteomes:UP000307069}, and
OG Plasmid unnamed {ECO:0000313|EMBL:ACD03291.1}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:AAF17880.1};
RN [1] {ECO:0000313|EMBL:AAF17880.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=9516014-1 {ECO:0000313|EMBL:AAF17880.1};
RX PubMed=10582907;
RA Sandvang D.;
RT "Novel streptomycin and spectinomycin resistance gene as a gene cassette
RT within a class 1 integron isolated from Escherichia coli.";
RL Antimicrob. Agents Chemother. 43:3036-3038(1999).
RN [2] {ECO:0000313|EMBL:AAD50826.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=INS33 {ECO:0000313|EMBL:AAD50826.1};
RX PubMed=10620677; DOI=10.1111/j.1574-6968.2000.tb08906.x;
RA White P.A., McIver C.J., Deng Y., Rawlinson W.D.;
RT "Characterisation of two new gene cassettes, aadA5 and dfrA17.";
RL FEMS Microbiol. Lett. 182:265-269(2000).
RN [3] {ECO:0000313|EMBL:AAD50910.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EC107 {ECO:0000313|EMBL:AAD50910.1};
RX PubMed=10882694; DOI=10.1093/jac/46.1.87;
RA Chang C.Y., Chang L.L., Chang Y.H., Lee T.M., Li Y.H., Chang S.F.;
RT "Two new gene cassettes, dfr17 (for trimethoprim resistance) and aadA4 (for
RT spectinomycin/streptomycin resistance), inserted in an Escherichia coli
RT class 1 integron.";
RL J. Antimicrob. Chemother. 46:87-89(2000).
RN [4] {ECO:0000313|EMBL:AAV69850.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15383699;
RA Zhang H., Shi L., Li L., Guo S., Zhang X., Yamasaki S., Miyoshi S.,
RA Shinoda S.;
RT "Identification and characterization of class 1 integron resistance gene
RT cassettes among Salmonella strains isolated from healthy humans in China.";
RL Microbiol. Immunol. 48:639-645(2004).
RN [5] {ECO:0000313|EMBL:BAD38869.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=D20 {ECO:0000313|EMBL:BAD38869.1};
RA Su J.Y., Shi L., Zheng M.P., Yang L.S., Cao Y.C., Li L., Li X.H.;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:AAV69850.1}
RP NUCLEOTIDE SEQUENCE.
RA Lu S.-J., Guan X.-Z., Liu Y.-N.;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:AAT37605.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A2363 {ECO:0000313|EMBL:AAT37605.1};
RC PLASMID=pAPEC-O2-R {ECO:0000313|EMBL:AAT37605.1};
RX PubMed=16251312; DOI=10.1128/AAC.49.11.4681-4688.2005;
RA Johnson T.J., Siek K.E., Johnson S.J., Nolan L.K.;
RT "DNA sequence and comparative genomics of pAPEC-O2-R, an avian pathogenic
RT Escherichia coli transmissible R plasmid.";
RL Antimicrob. Agents Chemother. 49:4681-4688(2005).
RN [8] {ECO:0000313|EMBL:AAY43142.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C262 {ECO:0000313|EMBL:AAY43142.1};
RX PubMed=15837385; DOI=10.1016/j.femsle.2005.03.021;
RA Du X., Shen Z., Wu B., Xia S., Shen J.;
RT "Characterization of class 1 integrons-mediated antibiotic resistance among
RT calf pathogenic Escherichia coli.";
RL FEMS Microbiol. Lett. 245:295-298(2005).
RN [9] {ECO:0000313|EMBL:BAD38869.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=D20 {ECO:0000313|EMBL:BAD38869.1};
RX PubMed=16451182; DOI=10.1111/j.1574-6968.2005.00025.x;
RA Su J., Shi L., Yang L., Xiao Z., Li X., Yamasaki S.;
RT "Analysis of integrons in clinical isolates of Escherichia coli in China
RT during the last six years.";
RL FEMS Microbiol. Lett. 254:75-80(2006).
RN [10] {ECO:0000313|EMBL:BAD38869.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=D20 {ECO:0000313|EMBL:BAD38869.1};
RX PubMed=16785718;
RA Shi L., Zheng M., Xiao Z., Asakura M., Su J., Li L., Yamasaki S.;
RT "Unnoticed spread of class 1 integrons in gram-positive clinical strains
RT isolated in Guangzhou, China.";
RL Microbiol. Immunol. 50:463-467(2006).
RN [11] {ECO:0000313|EMBL:ABG46353.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E3 {ECO:0000313|EMBL:ABG46353.1};
RA Vo A.T.T., van Duijkeren E., Fluit A.C., Gaastra W.;
RT "Class I integron in Escherichia coli.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:ABG46353.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E3 {ECO:0000313|EMBL:ABG46353.1};
RX PubMed=17521833; DOI=10.1016/j.vetmic.2007.04.027;
RA Vo A.T., van Duijkeren E., Fluit A.C., Gaastra W.;
RT "Characteristics of extended-spectrum cephalosporin-resistant Escherichia
RT coli and Klebsiella pneumoniae isolates from horses.";
RL Vet. Microbiol. 124:248-255(2007).
RN [13] {ECO:0000313|EMBL:ABP35555.1}
RP NUCLEOTIDE SEQUENCE.
RA Wang G., Shen J.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [14] {ECO:0000313|EMBL:ACF04951.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ZJ157 {ECO:0000313|EMBL:ACF04951.1};
RX PubMed=18647745; DOI=10.1093/jac/dkn300;
RA Su Z., Dai X., Chen J., Kong F., Wang H., Li Y., Peng S., Wang S., Shao Q.,
RA Lv L., Xu H.;
RT "The bla(CTX-M-1) gene located in a novel complex class I integron bearing
RT an ISCR1 element in Escherichia coli isolates from Zhenjiang, China.";
RL J. Antimicrob. Chemother. 62:1150-1151(2008).
RN [15] {ECO:0000313|EMBL:ABP35555.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17897793; DOI=10.1016/j.vetmic.2007.08.003;
RA Wang G.Q., Wu C.M., Du X.D., Shen Z.Q., Song L.H., Chen X., Shen J.Z.;
RT "Characterization of integrons-mediated antimicrobial resistance among
RT Escherichia coli strains isolated from bovine mastitis.";
RL Vet. Microbiol. 127:73-78(2008).
RN [16] {ECO:0000313|EMBL:ACD03291.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ECT10 {ECO:0000313|EMBL:ACD03291.1};
RC PLASMID=unnamed {ECO:0000313|EMBL:ACD03291.1};
RA Nawaz M.N., Khan A.A., Khan S., Sung K., Kerdahi K., Steele R.;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [17] {ECO:0000313|EMBL:ACQ42057.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A {ECO:0000313|EMBL:ACQ42057.1};
RC PLASMID=pEK499 {ECO:0000313|EMBL:ACQ42057.1};
RX PubMed=19687243; DOI=10.1128/AAC.00688-09;
RA Woodford N., Carattoli A., Karisik E., Underwood A., Ellington M.J.,
RA Livermore D.M.;
RT "Complete Nucleotide Sequences of Plasmids pEK204, pEK499, and pEK516,
RT Encoding CTX-M Enzymes in Three Major Escherichia coli Lineages from the
RT United Kingdom, All Belonging to the International O25:H4-ST131 Clone.";
RL Antimicrob. Agents Chemother. 53:4472-4482(2009).
RN [18] {ECO:0000313|EMBL:ACJ47209.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=unnamed {ECO:0000313|EMBL:ACJ47209.1};
RX PubMed=19538087; DOI=10.1086/600301;
RA Ajiboye R.M., Solberg O.D., Lee B.M., Raphael E., Debroy C., Riley L.W.;
RT "Global spread of mobile antimicrobial drug resistance determinants in
RT human and animal Escherichia coli and Salmonella strains causing community-
RT acquired infections.";
RL Clin. Infect. Dis. 49:365-371(2009).
RN [19] {ECO:0000313|EMBL:ACL98094.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EC_435-1 {ECO:0000313|EMBL:ACL98094.1};
RA Laroche E., Pawlak B., Berthe T., Skurnik D., Petit F.;
RT "Occurrence of antibiotic resistance and class 1, 2 and 3 integrons in
RT Escherichia coli isolated from a densely populated estuary (Seine,
RT France).";
RL FEMS Microbiol. Ecol. 68:118-130(2009).
RN [20] {ECO:0000313|EMBL:ACD03291.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ECT10 {ECO:0000313|EMBL:ACD03291.1};
RC PLASMID=unnamed {ECO:0000313|EMBL:ACD03291.1};
RX PubMed=19388830; DOI=10.1089/fpd.2008.0204;
RA Nawaz M., Khan A.A., Khan S., Sung K., Kerdahi K., Steele R.;
RT "Molecular characterization of tetracycline-resistant genes and integrons
RT from avirulent strains of Escherichia coli isolated from catfish.";
RL Foodborne Pathog. Dis. 6:553-559(2009).
RN [21] {ECO:0000313|EMBL:ACC93626.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=P65 {ECO:0000313|EMBL:ACC93626.1};
RX PubMed=19744463; DOI=10.1016/j.actatropica.2009.08.028;
RA Lu L., Dai L., Wang Y., Wu C., Chen X., Li L., Qi Y., Xia L., Shen J.;
RT "Characterization of antimicrobial resistance and integrons among
RT Escherichia coli isolated from animal farms in Eastern China.";
RL Acta Trop. 113:20-25(2010).
RN [22] {ECO:0000313|EMBL:ACJ22909.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=D3 {ECO:0000313|EMBL:ACJ22909.1};
RA Sandalli C., Buruk C.K., Sancaktar M., Ozgumus O.B.;
RT "Prevalence of integrons and a new dfrA17 variant in Gram-negative bacilli
RT which cause community-acquired infections.";
RL Microbiol. Immunol. 54:164-169(2010).
RN [23] {ECO:0000313|EMBL:AER36615.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Transconjugant Tx118 {ECO:0000313|EMBL:AER36615.1};
RC PLASMID=pJIE118 {ECO:0000313|EMBL:AER36615.1};
RX PubMed=21859935; DOI=10.1128/AAC.00025-11;
RA Partridge S.R., Zong Z., Iredell J.R.;
RT "Recombination in IS26 and Tn2 in the Evolution of Multiresistance Regions
RT Carrying blaCTX-M-15 on Conjugative IncF Plasmids from Escherichia coli.";
RL Antimicrob. Agents Chemother. 55:4971-4978(2011).
RN [24] {ECO:0000313|EMBL:AIM47121.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GCK 27 {ECO:0000313|EMBL:AIM47121.1};
RX PubMed=25167818;
RA Kotlarska E., Luczkiewicz A., Pisowacka M., Burzynski A.;
RT "Antibiotic resistance and prevalence of class 1 and 2 integrons in
RT Escherichia coli isolated from two wastewater treatment plants, and their
RT receiving waters (Gulf of Gdansk, Baltic Sea, Poland).";
RL Environ. Sci. Pollut. Res. Int. 0:0-0(2014).
RN [25] {ECO:0000313|EMBL:AJM90859.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HV114 {ECO:0000313|EMBL:AJM90859.1};
RC PLASMID=pHV114 {ECO:0000313|EMBL:AJM90859.1};
RX PubMed=25324838; DOI=10.3389/fmicb.2014.00519;
RA Zurfluh K., Wang J., Klumpp J., Nuesch-Inderbinen M., Fanning S.,
RA Stephan R.;
RT "Vertical transmission of highly similar bla CTX-M-1-harboring IncI1
RT plasmids in Escherichia coli with different MLST types in the poultry
RT production pyramid.";
RL Front. Microbiol. 5:519-519(2014).
RN [26] {ECO:0000313|EMBL:AIG72713.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ESBL-305 {ECO:0000313|EMBL:AIG72713.1};
RC PLASMID=pESBL-305 {ECO:0000313|EMBL:AIG72713.1};
RX PubMed=25169863;
RA Brouwer M.S., Bossers A., Harders F., van Essen-Zandbergen A., Mevius D.J.,
RA Smith H.E.;
RT "Complete Genome Sequences of IncI1 Plasmids Carrying Extended-Spectrum
RT beta-Lactamase Genes.";
RL Genome Announc. 2:e00859-14(2014).
RN [27] {ECO:0000313|EMBL:AIF79063.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Chicken-49 {ECO:0000313|EMBL:AIF79063.1};
RC PLASMID=pC49-108 {ECO:0000313|EMBL:AIF79063.1};
RX PubMed=24920651; DOI=10.1093/jac/dku206;
RA Wang J., Stephan R., Power K., Yan Q., Hachler H., Fanning S.;
RT "Nucleotide sequences of 16 transmissible plasmids identified in nine
RT multidrug-resistant Escherichia coli isolates expressing an ESBL phenotype
RT isolated from food-producing animals and healthy humans.";
RL J. Antimicrob. Chemother. 69:2658-2668(2014).
RN [28] {ECO:0000313|EMBL:AIG72713.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ESBL-305 {ECO:0000313|EMBL:AIG72713.1};
RC PLASMID=pESBL-305 {ECO:0000313|EMBL:AIG72713.1};
RA Brouwer M.S.M., Bossers A., Harders F., Mevius D.J., Smith H.E.;
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN [29] {ECO:0000313|EMBL:AKD26486.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CA14 {ECO:0000313|EMBL:AKD26486.1};
RC PLASMID=pCA14 {ECO:0000313|EMBL:AKD26486.1};
RX PubMed=25753630; DOI=10.1128/AAC.04772-14;
RA Li J.J., Spychala C.N., Hu F., Sheng J.F., Doi Y.;
RT "Complete nucleotide sequences of bla(CTX-M)-harboring IncF plasmids from
RT community-associated Escherichia coli strains in the United States.";
RL Antimicrob. Agents Chemother. 59:3002-3007(2015).
RN [30] {ECO:0000313|EMBL:AIY22993.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=YDC637 {ECO:0000313|EMBL:AIY22993.1};
RC PLASMID=pYDC637 {ECO:0000313|EMBL:AIY22993.1};
RX PubMed=25896689; DOI=10.1128/AAC.00852-15;
RA Lee C.S., Li J.J., Doi Y.;
RT "Complete Sequence of Conjugative IncA/C Plasmid Encoding CMY-2 ?-Lactamase
RT and RmtE 16S rRNA Methyltransferase.";
RL Antimicrob. Agents Chemother. 59:4360-4361(2015).
RN [31] {ECO:0000313|EMBL:AKN35618.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M63 {ECO:0000313|EMBL:AKN35618.1};
RC PLASMID=pESCR {ECO:0000313|EMBL:AKN35618.1};
RX PubMed=26077254; DOI=10.1128/AAC.00177-15;
RA Fleury M.A., Mourand G., Jouy E., Touzain F., Le Devendec L.,
RA de Boisseson C., Eono F., Cariolet R., Guerin A., Le Goff O.,
RA Blanquet-Diot S., Alric M., Kempf I.;
RT "Impact of ceftiofur injection on gut microbiota and Escherichia coli
RT resistance in pigs.";
RL Antimicrob. Agents Chemother. 59:5171-5180(2015).
RN [32] {ECO:0000313|EMBL:ALL73823.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MDJ-203 {ECO:0000313|EMBL:ALL73823.1};
RX PubMed=26500640; DOI=10.3389/fmicb.2015.01103;
RA Xu G., An W., Wang H., Zhang X.;
RT "Prevalence and characteristics of extended-spectrum ?-lactamase genes in
RT Escherichia coli isolated from piglets with post-weaning diarrhea in
RT Heilongjiang province, China.";
RL Front. Microbiol. 6:1103-1103(2015).
RN [33] {ECO:0000313|EMBL:AKD26486.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CA14 {ECO:0000313|EMBL:AKD26486.1};
RC PLASMID=pCA14 {ECO:0000313|EMBL:AKD26486.1};
RA Li J.-J., Doi Y.;
RT "CTX-M-encoding plasmid pCA14 from community associated ESBL-producing
RT E.coli.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [34] {ECO:0000313|EMBL:HAH4526954.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EC00763 {ECO:0000313|EMBL:HAH4526954.1}, and EuSCAPE_DE065
RC {ECO:0000313|EMBL:HAJ5960808.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [35] {ECO:0000313|EMBL:SPE02109.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=13948 {ECO:0000313|EMBL:SPE02109.1};
RA Cohen D.B., Kent A.D.;
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN [36] {ECO:0000313|Proteomes:UP000307069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=13948 {ECO:0000313|Proteomes:UP000307069};
RC PLASMID=rcs76_pi {ECO:0000313|Proteomes:UP000307069};
RA Cea G.-C., William W.;
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN [37] {ECO:0000313|EMBL:EFB4535520.1, ECO:0000313|Proteomes:UP000542214}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FSIS11706358 {ECO:0000313|EMBL:EFB4535520.1,
RC ECO:0000313|Proteomes:UP000542214}, and FSIS11923834
RC {ECO:0000313|EMBL:EFE8675069.1, ECO:0000313|Proteomes:UP000533482};
RG NARMS: The National Antimicrobial Resistance Monitoring System;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [38] {ECO:0000313|EMBL:RRD68299.1, ECO:0000313|Proteomes:UP000271008}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GBGD28 {ECO:0000313|EMBL:RRD68299.1,
RC ECO:0000313|Proteomes:UP000271008};
RA Shen C., Yang Y., Tian G.;
RT "Enterobacteriaceae from Patient.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [39] {ECO:0000313|EMBL:HAJ5960808.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EC00763 {ECO:0000313|EMBL:HAH4526954.1}, and EuSCAPE_DE065
RC {ECO:0000313|EMBL:HAJ5960808.1};
RG NCBI Pathogen Detection Project;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN [40] {ECO:0000313|EMBL:MQK27398.1, ECO:0000313|Proteomes:UP000359125}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A016f {ECO:0000313|EMBL:MQK27398.1,
RC ECO:0000313|Proteomes:UP000359125};
RX PubMed=31642700; DOI=.1289/EHP5251;
RA Li J., Bi Z., Ma S., Chen B., Cai C., He J., Schwarz S., Sun C., Zhou Y.,
RA Yin J., Hulth A., Wang Y., Shen Z., Wang S., Wu C., Nilsson L.E.,
RA Walsh T.R., Borjesson S., Shen J., Sun Q., Wang Y.;
RT "Inter-host Transmission of Carbapenemase-Producing Escherichia coli among
RT Humans and Backyard Animals.";
RL Environ. Health Perspect. 127:107009-107009(2019).
RN [41] {ECO:0000313|EMBL:BBU87663.1, ECO:0000313|Proteomes:UP000467488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E300 {ECO:0000313|EMBL:BBU87663.1,
RC ECO:0000313|Proteomes:UP000467488};
RA Abe R., Akeda Y., Sugawara Y., Yamamoto N., Tomono K., Takeuchi D.,
RA Kawahara R., Hamada S.;
RT "Dynamics of blaIMP-6 dissemination in carbapenem resistant
RT Enterobacteriacea isolated from regional surveillance in Osaka, Japan.";
RL Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
RN [42] {ECO:0000313|EMBL:MBF9179898.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E3 {ECO:0000313|EMBL:MBF9179898.1};
RA Hetsa B., Amoako D.G., Akebe A.L., Asante J., Essack S.Y.;
RT "Genomic surveiliance of eskapee pathogens from blood stream infections in
RT kzn.";
RL Submitted (NOV-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC Evidence={ECO:0000256|ARBA:ARBA00035070};
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DR EMBL; AF169041; AAD50826.1; -; Genomic_DNA.
DR EMBL; AF170088; AAD50910.1; -; Genomic_DNA.
DR EMBL; AF137361; AAF17880.1; -; Genomic_DNA.
DR EMBL; AY214164; AAT37605.1; -; Genomic_DNA.
DR EMBL; AY828551; AAV69850.1; -; Genomic_DNA.
DR EMBL; DQ018381; AAY43142.1; -; Genomic_DNA.
DR EMBL; DQ663488; ABG46353.1; -; Genomic_DNA.
DR EMBL; EF488368; ABP35555.1; -; Genomic_DNA.
DR EMBL; EU598449; ACC93626.1; -; Genomic_DNA.
DR EMBL; EU650403; ACD03291.1; -; Genomic_DNA.
DR EMBL; EU687490; ACF04951.1; -; Genomic_DNA.
DR EMBL; FJ001843; ACJ22909.1; -; Genomic_DNA.
DR EMBL; FJ381673; ACJ47209.1; -; Genomic_DNA.
DR EMBL; FJ591051; ACL98094.1; -; Genomic_DNA.
DR EMBL; EU935739; ACQ42057.1; -; Genomic_DNA.
DR EMBL; EU418924; AER36615.1; -; Genomic_DNA.
DR EMBL; KJ484638; AIF79063.1; -; Genomic_DNA.
DR EMBL; CP008737; AIG72713.1; -; Genomic_DNA.
DR EMBL; KJ192400; AIM47121.1; -; Genomic_DNA.
DR EMBL; KP056256; AIY22993.1; -; Genomic_DNA.
DR EMBL; KM377238; AJM90859.1; -; Genomic_DNA.
DR EMBL; CP009231; AKD26486.1; -; Genomic_DNA.
DR EMBL; KR494248; AKN35618.1; -; Genomic_DNA.
DR EMBL; KT692981; ALL73823.1; -; Genomic_DNA.
DR EMBL; AB189264; BAD38869.1; -; Genomic_DNA.
DR EMBL; AP022360; BBU87663.1; -; Genomic_DNA.
DR EMBL; AASFZR010000146; EFB4535520.1; -; Genomic_DNA.
DR EMBL; AASFZR010000303; EFB4536040.1; -; Genomic_DNA.
DR EMBL; AASOHJ010000025; EFE8675069.1; -; Genomic_DNA.
DR EMBL; AASOHJ010000156; EFE8676688.1; -; Genomic_DNA.
DR EMBL; DABBJX010000056; HAH4526954.1; -; Genomic_DNA.
DR EMBL; DABHXT010000049; HAJ5960808.1; -; Genomic_DNA.
DR EMBL; DABHXT010000174; HAJ5961692.1; -; Genomic_DNA.
DR EMBL; JADQTC010000902; MBF9179898.1; -; Genomic_DNA.
DR EMBL; RYCF01000194; MQK27398.1; -; Genomic_DNA.
DR EMBL; RQTU01000245; RRD68299.1; -; Genomic_DNA.
DR EMBL; LT985286; SPE02109.1; -; Genomic_DNA.
DR RefSeq; WP_000503573.1; NZ_WWEL01000045.1.
DR RefSeq; YP_001816600.1; NC_010558.1.
DR RefSeq; YP_003108350.1; NC_013122.1.
DR RefSeq; YP_009061546.1; NC_024979.1.
DR RefSeq; YP_009068730.1; NC_025142.1.
DR RefSeq; YP_009068856.1; NC_025143.1.
DR RefSeq; YP_009069124.1; NC_025144.1.
DR RefSeq; YP_009070862.1; NC_025176.1.
DR RefSeq; YP_190214.1; NC_006671.1.
DR KEGG; ag:AAF17880; -.
DR PATRIC; fig|562.10483.peg.5691; -.
DR BRENDA; 2.7.7.47; 2026.
DR Proteomes; UP000271008; Unassembled WGS sequence.
DR Proteomes; UP000307069; Plasmid rcs76_pi.
DR Proteomes; UP000359125; Unassembled WGS sequence.
DR Proteomes; UP000467488; Chromosome.
DR Proteomes; UP000533482; Unassembled WGS sequence.
DR Proteomes; UP000542214; Unassembled WGS sequence.
DR Proteomes; UP000647581; Unassembled WGS sequence.
DR Proteomes; UP000846355; Unassembled WGS sequence.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd05403; NT_KNTase_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR025184; AadA_C.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR Pfam; PF13427; AadA_C; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE 4: Predicted;
KW Nucleotidyltransferase {ECO:0000313|EMBL:AAD50910.1};
KW Oxidoreductase {ECO:0000313|EMBL:ALL73823.1};
KW Plasmid {ECO:0000313|EMBL:AAT37605.1};
KW Transferase {ECO:0000313|EMBL:AAF17880.1}.
FT DOMAIN 29..59
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 153..255
FT /note="Adenylyltransferase AadA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13427"
SQ SEQUENCE 262 AA; 29042 MW; 94DD4B1AD7941B1C CRC64;
MGEFFPAQVF KQLSHARAVI ERHLAATLDT IHLFGSAIDG GLKPDSDIDL LVTVSAAPND
SLRQALMLDL LKVSSPPGDG GTWRPLELTV VARSEVVPWR YPARRELQFG EWLRHDILSG
TFEPAVLDHD LAILLTKARQ HSLALLGPSA ATFFEPVPKE HFSKALFDTI AQWNAESDWK
GDERNVVLAL ARIWYSASTG LIAPKDVAAA WVSERLPAEH RPLICKARAA YLGSEDDDLA
MRVEETAAFV RYAKATIERI LR
//
