ID Q9U5A8_BOMMO Unreviewed; 1472 AA.
AC Q9U5A8;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 158.
DE RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312};
DE EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312};
GN Name=BIR {ECO:0000313|EMBL:AAF21243.1};
OS Bombyx mori (Silk moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Bombycidae; Bombycinae; Bombyx.
OX NCBI_TaxID=7091 {ECO:0000313|EMBL:AAF21243.1};
RN [1] {ECO:0000313|EMBL:AAF21243.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Ovary vitellogenic follicles {ECO:0000313|EMBL:AAF21243.1};
RA Lindstrom-Dinnetz I., Iatrou K.;
RT "Cloning and functional characterization of an insulin receptor-like mRNA
RT expressed in the silkmoth ovary.";
RL Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000005204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=p50T {ECO:0000313|Proteomes:UP000005204};
RX PubMed=19121390; DOI=10.1016/j.ibmb.2008.11.004;
RG International Silkworm Genome Consortium;
RT "The genome of a lepidopteran model insect, the silkworm Bombyx mori.";
RL Insect Biochem. Mol. Biol. 38:1036-1045(2008).
RN [3] {ECO:0000313|EnsemblMetazoa:NP_001037011.1}
RP IDENTIFICATION.
RC STRAIN=p50T (Dazao) {ECO:0000313|EnsemblMetazoa:NP_001037011.1};
RG EnsemblMetazoa;
RL Submitted (JUN-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171,
CC ECO:0000256|RuleBase:RU000312};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. Insulin receptor subfamily.
CC {ECO:0000256|RuleBase:RU000312}.
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DR EMBL; AF025542; AAF21243.1; -; mRNA.
DR RefSeq; NP_001037011.1; NM_001043546.1.
DR SMR; Q9U5A8; -.
DR EnsemblMetazoa; NM_001043546.1; NP_001037011.1; GeneID_692560.
DR GeneID; 692560; -.
DR KEGG; bmor:692560; -.
DR CTD; 42549; -.
DR HOGENOM; CLU_000288_166_5_1; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000005204; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0043560; F:insulin receptor substrate binding; IEA:InterPro.
DR GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IEA:InterPro.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR GO; GO:0000003; P:reproduction; IEA:UniProt.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd00064; FU; 1.
DR CDD; cd05032; PTKc_InsR_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016246; Tyr_kinase_insulin-like_rcpt.
DR InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR PANTHER; PTHR24416:SF525; INSULIN-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PIRSF; PIRSF000620; Insulin_receptor; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00261; FU; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000620-
KW 2}; Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR000620-2};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU000312};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000312};
KW Reference proteome {ECO:0000313|Proteomes:UP000005204};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000312};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 663..767
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 909..1014
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1082..1360
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1426..1472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1433..1451
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1221
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000620-1"
FT BINDING 1092
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000620-2"
FT BINDING 1116
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000620-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
FT BINDING 1163..1169
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000620-2"
FT BINDING 1225..1226
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000620-2"
FT BINDING 1239
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000620-2"
SQ SEQUENCE 1472 AA; 164583 MW; CB6631C67906AF8E CRC64;
MLEVRRGVMR RACDRLGWPA VACALLIACA RTYAGTEVVP ARGVCPSMDL RNNPDQIRRL
EGCRVIEGQL SIVLMERATN KIFDNMSFPQ LREVTGYILI YKTKGLRNLG DLFPNLPVVR
GMQLFKDFAL VIFDNEHLEA LGLNSLMKIE RGGVRIQHND RLCYTNTIDW SRITRDDAEI
IVRSNYDTRL CGLCPNAQSR VEEDHRQSLP QCPADTKGKL LCWDEKHCQK ICPSACGDHG
CMSNGTCCNS ACLGGCDGPL ASNCFVCKKF SFEYGSEMTC MESCPGGTYE LSRRCVTEQE
CRSMSPPPQP VGAADSTYFR FAIKVPAYKT FNSSRCLFMC PSGYMEVGNE TNATCQPCPR
SGCVRECLGG KIDSVATAEQ FRGCTHIKGK MEFTLRSSGG KTLSLLESAL GEIREIHGCL
QVTRSYPLVS LMFLKKLRKI IANPSEDKGE ALHIINNENL ELLWDWSTYG PIEIIGSCYI
HSNPKLCYTQ LMPLMNMSYP KTNFTELEVS QDSNGYQASC LPDVLKLSVS ELTQIAVVLT
WDVYCPDDMR KLLGYSLYFM ATEKNVSLYD QRDACSDIWK VLDKPIEETR KVNRNAKPSH
ARNKTEVIFN PCADMQPLFY PITQLRPYTR YAAYVKTYTT IQDRKGAQSS IIYFRTLPMQ
PSPPTAVTVE LLTPHSIFIK WSPPTMPNGT IILYHVEVQA NSYNRPQILA GNINYCGNPS
ILANMIKASL EEAPETPEEK ITGDVKNGVC ACKEEAKPSL RFSTRAEEER VDSINFENEL
QNQVYRKSER VNPKIHKSID GTSKVKRSVD HSLNSMLVKL TENNSPRPGL NYSNITDDEG
YVKSLYYELD GSTRTLTVKN MRHFTWYTVN IWACRNKDLN ETDPVYAENW CSVRAYNTFR
TLELPNADVV SNFQVEIMPA NKTLPEVNVT WEPPLNPNGF VVAYNVHYSR IEDSAQGPDV
GLQSCITVDD YEANGHGYVL KTLSPGNYSV KVTPITVSGA GNVSEEIYVF IPERVSESGH
AWAWGVGAGG VVLALLVGAA VWYARRGLMS HAEASKLFAS VNPEYVPTVY VPDEWEVTRD
SIHFIRELGQ GSFGMVYEGI AKEIVKGKPE TRCAIKTVNE HATDRERIEF LNEASVMKAF
DTFHVVRLLG VVSRGQPTLV VMELMERGDL KTYLRSMRPD AEGSLPSSPP VPPTLQNILQ
MAIEIADGMA YLSAKKFVHR DLAARNCMVA GDLTVKVGDF GMTRDIYETD YYRKGTKGLM
PVRWMSPESL KDGVFSSSSD AWSYGVVLWE MATLAMQPYQ GLSNEQVLRY VVEGGVMERP
EQCPDRLYEL MRACWTHRPS ARPTFLQLVA DLVPHAMPYF RHRSFFHSPQ GQELYALQRS
ALDEEQELPE VDVGAVATGS VSNLFGVSGR LASWVRELSS LRSRGSDDAA AEPLQPLPPP
GTSPAPILAP APAIKGPNGV LRDSHSARFR NH
//
