ID Q9UW64_CRYNE Unreviewed; 125 AA.
AC Q9UW64;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=orotate phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00011971};
DE EC=2.4.2.10 {ECO:0000256|ARBA:ARBA00011971};
DE Flags: Fragment;
GN Name=URA5 {ECO:0000313|EMBL:AAD51147.1};
OS Cryptococcus neoformans (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=5207 {ECO:0000313|EMBL:AAD51147.1};
RN [1] {ECO:0000313|EMBL:AAD51147.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11050543; DOI=10.1046/j.1365-294x.2000.01021.x;
RA Xu J., Vilgalys R., Mitchell T.G.;
RT "Multiple gene genealogies reveal recent dispersion and hybridization in
RT the human pathogenic fungus Cryptococcus neoformans.";
RL Mol. Ecol. 9:1471-1481(2000).
CC -!- FUNCTION: Catalyzes the transfer of a ribosyl phosphate group from 5-
CC phosphoribose 1-diphosphate to orotate, leading to the formation of
CC orotidine monophosphate (OMP). {ECO:0000256|ARBA:ARBA00003769}.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 1/2. {ECO:0000256|ARBA:ARBA00004889}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC family. PyrE subfamily. {ECO:0000256|ARBA:ARBA00006340}.
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DR EMBL; AF140193; AAD51147.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9UW64; -.
DR UniPathway; UPA00070; UER00119.
DR GO; GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06223; PRTases_typeI; 1.
DR Gene3D; 3.40.50.2020; -; 1.
DR HAMAP; MF_01208; PyrE; 1.
DR InterPro; IPR023031; OPRT.
DR InterPro; IPR004467; Or_phspho_trans_dom.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR NCBIfam; TIGR00336; pyrE; 1.
DR PANTHER; PTHR46683; OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED; 1.
DR PANTHER; PTHR46683:SF1; OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED; 1.
DR Pfam; PF00156; Pribosyltran; 1.
DR SUPFAM; SSF53271; PRTase-like; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000313|EMBL:AAD51147.1};
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|EMBL:AAD51147.1}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..125
FT /note="orotate phosphoribosyltransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004335322"
FT DOMAIN 31..124
FT /note="Phosphoribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00156"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAD51147.1"
FT NON_TER 125
FT /evidence="ECO:0000313|EMBL:AAD51147.1"
SQ SEQUENCE 125 AA; 13404 MW; 0AC1AC4D2661B842 CRC64;
FNVCLLYSSS LLSTTAHAYA KVLSSSRIPD FDVLFGPAYK GISLAAVSAV SLYQQTGKDI
GYCYNRKEKK DHGEGGTMVG APLKGRIVII DDVLTSGKAI REAIDILKAS PEAKLVGIVQ
LVDRQ
//
