ID Q9VA99_DROME Unreviewed; 1154 AA.
AC Q9VA99;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 5.
DT 24-JAN-2024, entry version 158.
DE RecName: Full=superoxide dismutase {ECO:0000256|ARBA:ARBA00012682};
DE EC=1.15.1.1 {ECO:0000256|ARBA:ARBA00012682};
GN Name=Rsod {ECO:0000313|FlyBase:FBgn0051028};
GN Synonyms=CG2176 {ECO:0000313|EMBL:AAF57015.5}, Dmel\CG31028
GN {ECO:0000313|EMBL:AAF57015.5};
GN ORFNames=CG31028 {ECO:0000313|EMBL:AAF57015.5,
GN ECO:0000313|FlyBase:FBgn0051028}, Dmel_CG31028
GN {ECO:0000313|EMBL:AAF57015.5};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF57015.5, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AAF57015.5, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:AAF57015.5, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:AAF57015.5, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:AAF57015.5, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AAF57015.5, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AAF57015.5, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AAF57015.5, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AAF57015.5, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
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DR EMBL; AE014297; AAF57015.5; -; Genomic_DNA.
DR RefSeq; NP_733352.3; NM_170473.3.
DR AlphaFoldDB; Q9VA99; -.
DR SMR; Q9VA99; -.
DR IntAct; Q9VA99; 1.
DR STRING; 7227.FBpp0288489; -.
DR PaxDb; 7227-FBpp0288490; -.
DR EnsemblMetazoa; FBtr0290050; FBpp0288489; FBgn0051028.
DR GeneID; 43586; -.
DR KEGG; dme:Dmel_CG31028; -.
DR UCSC; CG31028-RC; d. melanogaster.
DR AGR; FB:FBgn0051028; -.
DR FlyBase; FBgn0051028; Rsod.
DR VEuPathDB; VectorBase:FBgn0051028; -.
DR eggNOG; ENOG502QW6R; Eukaryota.
DR GeneTree; ENSGT00530000064791; -.
DR HOGENOM; CLU_004514_0_0_1; -.
DR InParanoid; Q9VA99; -.
DR OMA; VWSWAVR; -.
DR OrthoDB; 2912800at2759; -.
DR PhylomeDB; Q9VA99; -.
DR BioGRID-ORCS; 43586; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 43586; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0051028; Expressed in embryonic foregut (Drosophila) and 26 other cell types or tissues.
DR ExpressionAtlas; Q9VA99; baseline and differential.
DR Genevisible; Q9VA99; DM.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004784; F:superoxide dismutase activity; NAS:FlyBase.
DR Gene3D; 2.60.40.200; Superoxide dismutase, copper/zinc binding domain; 4.
DR InterPro; IPR036423; SOD-like_Cu/Zn_dom_sf.
DR InterPro; IPR001424; SOD_Cu_Zn_dom.
DR PANTHER; PTHR20910; AGAP001623-PA; 1.
DR PANTHER; PTHR20910:SF1; SOD_CU DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00080; Sod_Cu; 1.
DR SUPFAM; SSF49329; Cu,Zn superoxide dismutase-like; 5.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1154
FT /note="superoxide dismutase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004334468"
FT DOMAIN 697..821
FT /note="Superoxide dismutase copper/zinc binding"
FT /evidence="ECO:0000259|Pfam:PF00080"
SQ SEQUENCE 1154 AA; 129364 MW; 3FF7EE0C88D37FAF CRC64;
MAPGGRQLLW MASICWIASL MSGADAQHLI AYISQRGLHG EITFRQMNAT TVEIKANLEA
TLQYPDQVWS WGVRRFPVDY SNIDPDERCE LSRLGSQVLS FDEDLEYLVL PGNETSSWER
NMQLIGDRGI WGKSLVLTEV NANARICATI TTIQSSVEHM AEARFNTPVA GSVHFRWLAP
AEGAVGDTLI YSDLYHIRAQ PAALEEDRSQ AGPFTQHHWK IYVTDIFKHD HHRTEDNCNF
LQQVFDPQGS GAGKGIGDLD ARLGRIGVAK NALRSPQRSV FRDAQLALLP SDLTIPHRTL
YLVLFDNQHP DSYLACTKIR HVQPLTHKTF INSGGVKGEV TFMQRSKFDP TFLNFTLGAP
LSQHVSRKFA EDVAAFRIHS LPPVPSRMGH EDYCLTTGDM HNPREINENI PPPGYGTQEQ
YPVGDLSGKL QGRNKGYWHQ YVLPGTSSEL NGLYWDVFLP LQGRYSIAQR SLVIYTFNRS
NVTNITKMIW GCSSLSQYQR NGIYQQNMVT AQVLFRYPVV GRVIFRQTAE QPWQDTTVLF
EYLIQADGST QNTTHDHRWA IHSNAPGKDF YDWQQRCISA GPVYNPFRVD WGNRSVDDFC
RPSLASMCRV GAMDARSGTL TIAGGRRVAQ KISRKMFVDG NLPLSGRHSI LGKSLVIYED
SGPKARGERL ACSAVIGHFR RKVVAKEWYA NGDSLTVSGR VEITQQSEYD VSNVEVQLKG
LQDNTGYYIH RTPVEANLAF PCEASTLYGH WNPFDVSPKS SPPPKRGTTD QYEMGDLSGK
FGGLEGVTQF EDAYNDTNLP LFGYNSIIGR SVVIQKKQKN ARWACSTLER GYSPSEAREL
RAIASFHHPT GYAYGYIKMT QLIHNDGSQS ETVIEVKLRH PGKNDRNSTR NHNWQIFVNP
VGVDAAVKPT ITRCVAGGYV WNPYYTQLAD PLNLDLYEQE CSPDNPLRCY VGDVGARLGT
IDLGGERVVL TDSNFPLEAP VGAIGRSIVI FGPDHSHERF ACANIEPDHN VIKYINLQKP
PRFVVAQFLD ELRSVMGIPE WMLDVDARKT KELHGGACIQ MIIHFKGPLA HRLELDMSRL
IAAGRLDAPS LFIPGYVNQK RKATISYRTC GVRDTNEKRT KNFKGGFYSS SSAPNEPKPL
VLAFVVIGLA FRFL
//
