ID Q9WZZ8_THEMA Unreviewed; 336 AA.
AC Q9WZZ8; G4FCS9;
DT 01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1999, sequence version 1.
DT 27-MAR-2024, entry version 141.
DE SubName: Full=Galactose-1-phosphate uridylyltransferase, putative {ECO:0000313|EMBL:AAD35977.1};
GN OrderedLocusNames=TM_0896 {ECO:0000313|EMBL:AAD35977.1};
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Thermotogaceae;
OC Thermotoga.
OX NCBI_TaxID=243274 {ECO:0000313|EMBL:AAD35977.1, ECO:0000313|Proteomes:UP000008183};
RN [1] {ECO:0000313|EMBL:AAD35977.1, ECO:0000313|Proteomes:UP000008183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8
RC {ECO:0000313|Proteomes:UP000008183};
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D., Heidelberg J.,
RA Sutton G.G., Fleischmann R.D., White O., Salzberg S.L., Smith H.O.,
RA Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC type 1 family. {ECO:0000256|ARBA:ARBA00010951}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00464}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE000512; AAD35977.1; -; Genomic_DNA.
DR PIR; A72322; A72322.
DR RefSeq; NP_228704.1; NC_000853.1.
DR RefSeq; WP_004080684.1; NZ_CP011107.1.
DR AlphaFoldDB; Q9WZZ8; -.
DR PaxDb; 243274-THEMA_00155; -.
DR EnsemblBacteria; AAD35977; AAD35977; TM_0896.
DR KEGG; tma:TM0896; -.
DR KEGG; tmw:THMA_0918; -.
DR PATRIC; fig|243274.17.peg.897; -.
DR InParanoid; Q9WZZ8; -.
DR OrthoDB; 9769064at2; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0033499; P:galactose catabolic process via UDP-galactose; IEA:InterPro.
DR CDD; cd00608; GalT; 1.
DR Gene3D; 3.30.428.10; HIT-like; 2.
DR InterPro; IPR001937; GalP_UDPtransf1.
DR InterPro; IPR005850; GalP_Utransf_C.
DR InterPro; IPR005849; GalP_Utransf_N.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR NCBIfam; TIGR00209; galT_1; 1.
DR PANTHER; PTHR42763; ADP-GLUCOSE PHOSPHORYLASE; 1.
DR PANTHER; PTHR42763:SF1; UDP-GLUCOSE--HEXOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR Pfam; PF02744; GalP_UDP_tr_C; 1.
DR Pfam; PF01087; GalP_UDP_transf; 1.
DR PIRSF; PIRSF000808; GalT; 1.
DR SUPFAM; SSF54197; HIT-like; 2.
DR PROSITE; PS51084; HIT_2; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:AAD35977.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008183};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 197..308
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT ACT_SITE 166
FT /note="Tele-UMP-histidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000808-1"
SQ SEQUENCE 336 AA; 39483 MW; 792CE19EED698DA8 CRC64;
MPEFRKDPII KRWVIIATER AKRPHDFART KVEEVREGFC PFDYGNEHTT PPEIFAFRPA
DTEPNTPGWW VRVVPNKFPA VDPNAPLRKY GRGMYDAAMG FGYHDVVVET PDHNSHLAVM
DYKNVEEVIW AYKIRYEQLM KDERIKYILI FKNHGRDAGA SLSHPHSQII ALPIMPKRVQ
EELDGSKEYY EYKERCPFCD IIDEEKRERE RIVEENDHFI ALEPFAARFP FETWILPKRH
MNSFHLISED EVGSLAKILK NVLYRIYAAL DNPPYNLLIH TAPTSLEGKD YYHWHIEIFP
RLTKVAGFEW GTGFYINTVP PEDAARYLRE VSLEQV
//
