ID Q9X7E2_MYCLR Unreviewed; 3076 AA.
AC Q9X7E2;
DT 01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1999, sequence version 1.
DT 27-MAR-2024, entry version 133.
DE SubName: Full=Putative type I fatty acid synthase {ECO:0000313|EMBL:CAB39571.1};
GN Name=fas {ECO:0000313|EMBL:CAB39571.1};
OS Mycobacterium leprae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1769 {ECO:0000313|EMBL:CAB39571.1};
RN [1] {ECO:0000313|EMBL:CAB39571.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=8446027; DOI=10.1111/j.1365-2958.1993.tb01111.x;
RA Eiglmeier K., Honore N., Woods S.A., Caudron B., Cole S.T.;
RT "Use of an ordered cosmid library to deduce the genomic organization of
RT Mycobacterium leprae.";
RL Mol. Microbiol. 7:197-206(1993).
RN [2] {ECO:0000313|EMBL:CAB39571.1}
RP NUCLEOTIDE SEQUENCE.
RA James K.D., Parkhill J., Barrell B.G., Rajandream M.A.;
RL Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CAB39571.1}
RP NUCLEOTIDE SEQUENCE.
RA Seeger K.J., Harris D.;
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254}.
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DR EMBL; AL049478; CAB39571.1; -; Genomic_DNA.
DR PIR; A87058; A87058.
DR RefSeq; WP_010908189.1; NZ_CP029543.1.
DR SMR; Q9X7E2; -.
DR Leproma; ML1191; -.
DR OMA; WQVTRKA; -.
DR GO; GO:0005835; C:fatty acid synthase complex; IEA:InterPro.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NADH) activity; IEA:InterPro.
DR GO; GO:0004312; F:fatty acid synthase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00828; elong_cond_enzymes; 1.
DR CDD; cd03447; FAS_MaoC; 1.
DR CDD; cd08950; KR_fFAS_SDR_c_like; 1.
DR Gene3D; 1.20.930.70; -; 1.
DR Gene3D; 3.30.70.2430; -; 1.
DR Gene3D; 3.30.70.3320; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.90.25.70; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR013565; Fas1/AflB-like_central.
DR InterPro; IPR047224; FAS_alpha_su_C.
DR InterPro; IPR003965; Fatty_acid_synthase.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR10982:SF23; FATTY ACID SYNTHASE SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10982; MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF18094; DNA_pol_B_N; 1.
DR Pfam; PF08354; Fas1-AflB-like_hel; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR Pfam; PF16073; SAT; 1.
DR PRINTS; PR01483; FASYNTHASE.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 2542..2997
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 3076 AA; 328361 MW; D88556730478E549 CRC64;
MTIHEHDQVS ADRNGNSLHG SRALADRLKA GEPYVVAFGG QGSAWLETLE ELVSSAGLEA
DLATLVCEVE LLLEPVAKEL VVVRPIGFEP LQWVRALLAE DLVPSDKHLT SAAVSVPGVL
LTQIAVGRAL ARQGMDLIAT PPVGIVGHSQ GVLAVEALKA GGARDAELLA MAQLIGAAGT
LVARRRGISV LGDRPPMVSV TNADPERIRR LLDEFAQDVR TVLPPVLSIR NGWRSVVITG
TPEQLSRFER YCRQISDKEE EDRRKKIRGG DIFAPVFDPV QVEIGFHTPH LADGIGIVGG
WAEKVGLDVT LARELTEAIL VRGVDWVREI TRVHGAGVRW IIDLGPGDIL TRLTAPVIRG
LGVGIVPVAN RGGQRTLFTV GAVPEVVRAW LSYAPTVVQL PDGRIKLSTK FTRLTGRSPI
LLAGMTPTTV DANIVAAAAN AGHWAELAGG GQVTEEIFAN RVEQLSGLLE PGRTYQFNAL
FLDPYLWKLQ VGGKRLVQKA RQSGAAIDGV VISGGILDLE DAVELIEELG GIGISYVVFK
PGTIEQIRSV IRIATEMSTK PVIMHVEGGR AGGHHSWEDL DDLLLATYSE LRSHANITVC
VGGGIGTPEK AAEYLSGRWA QAYGFPLMPI DGILVGTAAM ATKEATTSPS VKRMLVETQG
TDQWIGSGKA QGGMASSRSQ LGADIHEIDN AASRCGRLLD EVAGDAEAVA ERRDEIIAAM
ANTAKPYFGD VSEMTYLQWL QRYVELTIGE GNSTADTASP GSPWLADTWR DRFQKMLQRA
ESRLHPSDFG LIKTIFTDPV LLEKPNQAIA ALLKYYPDAE TVQLHPADAP FFVMLCQMLG
KPVNFVPVID KDVRRWWRSD SLWQAHDARY DADQVCIIPG IAAVAGITQM DEPVGELLDR
FEQAAIDEVL AGGAEPVVVM SRRLGRADVA GPLAVVLDAP DVLWAGRIAT NPVHRIADPN
EWQVNGNLSA THSSTGAQLQ VKSEDQQVVL SVPVSNGWID IPFTLPTNTV DGGALLVSTE
DATSAMRAVL AIVAGVDGPE LLSPVKDGTA IVTVDWNPER VADHTGVTAT FREPLAPSLA
TVPDALVGAC WPAVFSAIGS AVTEAGVLVV EGLLNLLHLD HAVCVVGKLP TVPAQLTVTA
TVSLAIDTDM GRVVPVSVTI RDTTGADGAV LATLEERFVI LGRTGTAELT GPVRAGGAIS
ENATDTPRRR RRDVTLTAPI DMRPFAVVSG DHNPIHTDRT AALLAGLESP IVHGMWLSAA
AQHVVMATDG QARPAARLIG WTARFLGMAH PGDKVDFRVD RIGIDQGAEI LEVSARISSG
LVMSATARLA APKTVYAFPG QGIQHKGMGM DVRARSKAAR RVWDDADKFT RSGLGFSVLH
VVRDNPTNIT ANGVHYHHPD GVLYLTQFTQ VAMATVAVAQ VAEMREQGAF VEGAIACGHS
VGEYTALACV MGVYELEALL ETVFHRGSKM HDIVLRDELG RSNYRLAAIR PSQIGLPDDE
VPAFVRGIAE STGEFLEIVN FNLRGSQYAI AGTVHGLEAL EAEVERRREL TGGRRSFILV
PGIDVPFHSR VLRVGVAEFR RSLDRVLPQD QDPDWIIGRY IPNLVPRPFT LARDFIQEIR
DLVPAEPLDD ILADYDTWRR ERPSEMARRV LIELLAWQFA SPVRWIETQD LLFTEEAAGG
LGVERFVEIG VKSAPTVAGL ATDTLKLPEY SHNTVEVLNV ERDAAVLFAT DTDPELEPEP
ENVSDASAAL PAESALALGT VAPAPVVPSG PRPEDISFGA ADATLALIAL SAKMRLDQIE
EMDSIESITD GASSRRNQLL VDLGSELSLG AIDGVAEADL AGLRSQVTKL ARTYKPYGPV
LSELINDQLR SALGPSGKRP GVIAERVKKI WELGDGWVKH VTVEIALGTR EGTSVRGGPL
GNLNEGALAD VDSVDKAVDA AVASVAARHG VVVALPSAGS GGSATVDVAA LSEFTDQITG
HDGVLASAAR LVLGQLGLDG PVTAAPATTD TGLIDLVTAE LSTDWPRLVA PVFDVKKAVV
FDDRWASARE DLVRLWLNDE GEIEAQWSHL SERFEGAGHV VATQATWWQG KSLAAGRQIH
ASLYGRIAAG AQNPDRGLYS SEIAVVTGAS KGSIAASVAA RLLDGGATVI ATTSKLDEER
ITFYRALYRD HARYGAALWV VAANMASYSD IDALVEWIGN EQTESLGPQS IHIKDAQTPT
LLFPFAAPRV IGDLSEAGAR SEIEMKVLLW AVQRLIVGLS KIGTERDVAS RLHVVLPGSP
NRGMFGGDGA YGEAKSALDA VVSRWHAESS WAARVSLAHA LIGWTRGTGL MGHNDVIVSA
VEEAGVTTYS TDEMAAMLLD LCNAESKVAA AGTPITVDLT GGLGEVDLDM AELAAKARED
HAAQAAEDEA TEASEVAGTI AALPSPPRGY TPASPHWDDL DVDPADLVVI VGGAEIGPYG
SSRTRFEMEV AGELSAAGVL ELVWTTGLIR WEDDPQPGWY DTESGELVDE SELVERYHDT
VVQRCGIREF VDDGTIDPDH AYPLLVSVFL DKDFAFVVSS EADARAFVEF DPEHTVIRPV
PDSSDWQVIR KAGTEIRVPR KMKLSRVVGG QIPTGFDPTV WGISPDMVSS IDRVAVWSIV
ATVDAFLSAG FTPAEVMRYV HPSLVANTMG TGMGGGTSIQ RLYHSSLLGR NKPNDIFQEI
LPNIVAAHVV QSYIGSYGSM IHPVAACATA AVSVEEGVDK IRLGKAELVV AGGIDDLTLE
GIIGFGDMAA TADTAMMRGR GIHDSKFSRP NDRRRLGFVE AQGGGTILLA RGDLALKMGL
PVFAVVAFAQ SFGDGVHTSI PAPGLGALGA GRGGKDSPLV QSLAKLGVSA DDIAVISKHD
TSTLANDPNE TELHERLADA MGRSAGAPLF VVSQKSLTGH AKGGAAVFQM MGLCQMLRDG
VIPPNRSLDC VDEELAGAAH FVWLRDTLRL GEKFPLKAGM LTSLGFGHVS GLVALVHPQA
FIAALDPGQR DDYQRRANVR LLAGQRRLAS AIAGGAPMYE RPPDRRFDHH VPEKLQEAAM
LLNPAARLGD GDAYIG
//
