ID Q9XCC7_STRFR Unreviewed; 226 AA.
AC Q9XCC7;
DT 01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1999, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE SubName: Full=Gamma-butyrolactone receptor protein TylP {ECO:0000313|EMBL:AAD40801.1};
GN Name=tylP {ECO:0000313|EMBL:AAD40801.1};
OS Streptomyces fradiae (Streptomyces roseoflavus).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1906 {ECO:0000313|EMBL:AAD40801.1};
RN [1] {ECO:0000313|EMBL:AAD40801.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=T59235 {ECO:0000313|EMBL:AAD40801.1};
RX PubMed=10467127; DOI=10.1016/S1074-5521(99)80113-6;
RA Bate N., Butler A.R., Gandecha A.R., Cundliffe E.;
RT "Multiple regulatory genes in the tylosin biosynthetic cluster of
RT Streptomyces fradiae.";
RL Chem. Biol. 6:617-624(1999).
RN [2] {ECO:0007829|PDB:5XAY, ECO:0007829|PDB:5XAZ}
RP X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 2-226.
RX PubMed=28739805; DOI=10.1074/jbc.M117.788000;
RA Ray S., Maitra A., Biswas A., Panjikar S., Mondal J., Anand R.;
RT "Functional insights into the mode of DNA and ligand binding of the TetR
RT family regulator TylP from <i>Streptomyces fradiae</i>.";
RL J. Biol. Chem. 292:15301-15311(2017).
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DR EMBL; AF145049; AAD40801.1; -; Genomic_DNA.
DR PIR; T44586; T44586.
DR RefSeq; WP_043470766.1; NZ_MCNU01000172.1.
DR PDB; 5XAY; X-ray; 2.58 A; A/B/C/D/E/F/G/H=2-226.
DR PDB; 5XAZ; X-ray; 2.30 A; A/B/C/D/E/F/G/H=2-226.
DR PDBsum; 5XAY; -.
DR PDBsum; 5XAZ; -.
DR AlphaFoldDB; Q9XCC7; -.
DR SMR; Q9XCC7; -.
DR PATRIC; fig|1906.11.peg.6051; -.
DR eggNOG; COG1309; Bacteria.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProt.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR InterPro; IPR047923; ArpA-like.
DR InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR NCBIfam; NF041196; ScbR_bind_reg; 1.
DR PANTHER; PTHR47506:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR LMRA; 1.
DR PANTHER; PTHR47506; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS01081; HTH_TETR_1; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:5XAY, ECO:0007829|PDB:5XAZ};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW Receptor {ECO:0000313|EMBL:AAD40801.1};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 8..68
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 31..50
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 226 AA; 24820 MW; 863175B923E26DF4 CRC64;
MARQERAAQT RRTIVAAAAA VFDELGYEAT TIAEILKRSG VTKGALYFHF TSKEQLAQEV
LTSQLRAVPP VEEQRLVLQQ IIDETLLLAQ LLSKGDPLVR GSVRLTVEPG APRDGLDRRA
PMQEWIGHGR DLLRRAEAGG ELLPRLDVDA VARMLVGGFT GAQILSNILT GHADLLERVT
DMHRHLMTSV AVPAVLVRLD FSAERSITVY DEAMRRREAP LPAAGD
//
