ID   Q9XSI4_PIG              Unreviewed;       142 AA.
AC   Q9XSI4;
DT   01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1999, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   RecName: Full=Hypoxanthine-guanine phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00022099};
DE            EC=2.4.2.8 {ECO:0000256|ARBA:ARBA00011895};
DE   Flags: Fragment;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|EMBL:AAD30159.1};
RN   [1] {ECO:0000313|EMBL:AAD30159.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Landrace x Large White {ECO:0000313|EMBL:AAD30159.1};
RA   Gyoerffy A., Steinborn R., Balasch M., Plana-Duran J., Klein D.,
RA   Mueller M., Brem G.;
RT   "Variant pHPRT sequence.";
RL   Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAD30159.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Landrace x Large White {ECO:0000313|EMBL:AAD30159.1};
RX   PubMed=15847915; DOI=10.1016/j.jviromet.2005.01.018;
RA   Revilla-Fernandez S., Wallner B., Truschner K., Benczak A., Brem G.,
RA   Schmoll F., Mueller M., Steinborn R.;
RT   "The use of endogenous and exogenous reference RNAs for qualitative and
RT   quantitative detection of PRRSV in porcine semen.";
RL   J. Virol. Methods 126:21-30(2005).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from hypoxanthine: step 1/1. {ECO:0000256|ARBA:ARBA00004669}.
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DR   EMBL; AF143818; AAD30159.1; -; mRNA.
DR   AlphaFoldDB; Q9XSI4; -.
DR   HOGENOM; CLU_073615_3_0_1; -.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   PANTHER; PTHR43340; HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE; 1.
DR   PANTHER; PTHR43340:SF6; HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE; 1.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   SUPFAM; SSF53271; PRTase-like; 1.
PE   2: Evidence at transcript level;
KW   Glycosyltransferase {ECO:0000313|EMBL:AAD30159.1};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transferase {ECO:0000313|EMBL:AAD30159.1}.
FT   DOMAIN          23..142
FT                   /note="Phosphoribosyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00156"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAD30159.1"
FT   NON_TER         142
FT                   /evidence="ECO:0000313|EMBL:AAD30159.1"
SQ   SEQUENCE   142 AA;  15966 MW;  4FA8CEB7D25F4983 CRC64;
     DLFCIPNHYA EDLEKVFIPH GLIMDRTERL ARDVMKEMGG HHIVALCVLK GGYKFFADLL
     DYIKALNRNS DRSIPMTVDF IRLKSYCNDQ STGDIKVIGG DDLSTLTGKN VLIVEDIIDT
     GKTMQTLLSL VKQHNPKMVK VA
//