ID Q9XV68_CAEEL Unreviewed; 550 AA.
AC Q9XV68;
DT 01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1999, sequence version 1.
DT 27-MAR-2024, entry version 128.
DE SubName: Full=4-coumarate--CoA ligase 1-like {ECO:0000313|EMBL:CAB04170.1};
GN Name=acs-12 {ECO:0000313|EMBL:CAB04170.1,
GN ECO:0000313|WormBase:F25C8.4};
GN ORFNames=CELE_F25C8.4 {ECO:0000313|EMBL:CAB04170.1}, F25C8.4
GN {ECO:0000313|WormBase:F25C8.4};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB04170.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAB04170.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB04170.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; BX284605; CAB04170.1; -; Genomic_DNA.
DR PIR; T21326; T21326.
DR RefSeq; NP_508035.1; NM_075634.3.
DR AlphaFoldDB; Q9XV68; -.
DR SMR; Q9XV68; -.
DR IntAct; Q9XV68; 1.
DR STRING; 6239.F25C8.4.1; -.
DR EPD; Q9XV68; -.
DR PaxDb; 6239-F25C8-4; -.
DR PeptideAtlas; Q9XV68; -.
DR EnsemblMetazoa; F25C8.4.1; F25C8.4.1; WBGene00009106.
DR GeneID; 180375; -.
DR KEGG; cel:CELE_F25C8.4; -.
DR UCSC; F25C8.4; c. elegans.
DR AGR; WB:WBGene00009106; -.
DR WormBase; F25C8.4; CE18637; WBGene00009106; acs-12.
DR eggNOG; KOG1176; Eukaryota.
DR HOGENOM; CLU_000022_59_2_1; -.
DR InParanoid; Q9XV68; -.
DR OMA; EYRIICT; -.
DR OrthoDB; 2872672at2759; -.
DR PhylomeDB; Q9XV68; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00009106; Expressed in material anatomical entity and 4 other cell types or tissues.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016405; F:CoA-ligase activity; IBA:GO_Central.
DR CDD; cd05911; Firefly_Luc_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR24096:SF381; FATTY ACID COA SYNTHETASE FAMILY; 1.
DR PANTHER; PTHR24096; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
PE 1: Evidence at protein level;
KW Ligase {ECO:0000313|EMBL:CAB04170.1};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q9XV68};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 23..386
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 437..511
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 550 AA; 62317 MW; 2087441CFE8260A3 CRC64;
MIIKSKLPNL DIPDKTFHDF LFHEWEKFRE DVALIDNDTF AQFTFQDVMQ KADFIAKSLV
YLKVEKSEVV LLVMDWSPAA IYIALGASMA GAAIQVVSPK LQAWEMQFPV KESESRFVFS
DPLGLHEIDK LMKTLNREYR IICTGSRDFA NGYPIIEDLA FAAKQNLPLP KIEPDTDIVY
LPYSSGIHGK RKGIVTTHKV MVAKTMVMWN TSKHHEFRRG DTTLTMIPLH KQCGLDAILC
ALLNGLTVVT EKNFCVHTFM TCIQRYKIRA VHLTPYLMNL MMFEAENHTY NIESLEWVVT
GADAVTEELY EEFTEIFPSV KTVTQTYGMT EVGLICRTYN KNYSPSCGQL TANLEMKVLD
ILTGKELGPR EKGQICVKGI AAESPYLNNP KATEEHFLDG WRRTGDIGFF DEEGNVHLVD
KLKEMIKVFG YQVIPKEIET LLLTHQAVEE AAVVAINNEL SGERPVAFVV LKKGFVATED
DLKDYVNKRV IRYKHLVRVN ITQFLPKSAC GTLLRRLLAE AAVMSVASIA EVEKEFVPEL
PADMKSILTH
//
