ID Q9YH35_TETFL Unreviewed; 1106 AA.
AC Q9YH35;
DT 01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1999, sequence version 1.
DT 27-MAR-2024, entry version 132.
DE RecName: Full=Proto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000256|PIRNR:PIRNR000631};
DE EC=2.7.10.1 {ECO:0000256|PIRNR:PIRNR000631};
GN Name=RET {ECO:0000313|EMBL:AAD10845.1};
OS Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=47145 {ECO:0000313|EMBL:AAD10845.1};
RN [1] {ECO:0000313|EMBL:AAD10845.1}
RP NUCLEOTIDE SEQUENCE.
RA Leu J.H., Huang C.J.;
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor tyrosine-protein kinase involved in numerous
CC cellular mechanisms including cell proliferation, neuronal navigation,
CC cell migration, and cell differentiation upon binding with glial cell
CC derived neurotrophic factor family ligands.
CC {ECO:0000256|PIRNR:PIRNR000631}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171,
CC ECO:0000256|PIRNR:PIRNR000631};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR000631}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. {ECO:0000256|PIRNR:PIRNR000631}.
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DR EMBL; U58673; AAD10845.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9YH35; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd11304; Cadherin_repeat; 2.
DR CDD; cd05045; PTKc_RET; 1.
DR Gene3D; 2.60.40.60; Cadherins; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR041163; Ret_CLD1.
DR InterPro; IPR040667; Ret_CLD3.
DR InterPro; IPR041317; RET_CLD4.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016249; Tyr_kinase_Ret_rcpt.
DR PANTHER; PTHR24416:SF485; PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00028; Cadherin; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF17756; RET_CLD1; 1.
DR Pfam; PF17812; RET_CLD3; 1.
DR Pfam; PF17813; RET_CLD4; 1.
DR PIRSF; PIRSF000631; TyrPK_receptor_Ret; 1.
DR PRINTS; PR00205; CADHERIN.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00112; CA; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49313; Cadherin-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50268; CADHERIN_2; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000631};
KW Calcium {ECO:0000256|PROSITE-ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|PIRNR:PIRNR000631};
KW Cell membrane {ECO:0000256|PIRNR:PIRNR000631};
KW Kinase {ECO:0000256|PIRNR:PIRNR000631, ECO:0000313|EMBL:AAD10845.1};
KW Membrane {ECO:0000256|PIRNR:PIRNR000631};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000631, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Receptor {ECO:0000313|EMBL:AAD10845.1};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|PIRNR:PIRNR000631};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137,
KW ECO:0000256|PIRNR:PIRNR000631}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1106
FT /note="Proto-oncogene tyrosine-protein kinase receptor Ret"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004337048"
FT DOMAIN 193..266
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 716..1008
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 866
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000631-1"
FT BINDING 750
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1106 AA; 124995 MW; EC4045464974D56A CRC64;
MGSSYGFSRG NVILMLLLLL LDGVRGLYFS QSEYIETVYV GQPAGTPVLQ VHALRDNVSQ
LPHFYLCWVK FLRRPAYISW FSLDVNTGVL YLNKTLEESD FASVYQSNQA VKKLSLHVMA
SPGFTKKPLC NSRNYPRITL DFVNALMPQC GETDLKELCF PRKDTSNPHI TENRFPGGLR
QLRRLSWLNV CPNYTISYSV ETESPAPFAV NENTTELVVT APLDREESES YRLLLVCTVR
TEAVITKVET SLDVFVDDED DNAPYMNGTD TSDIVISFNR TAGGSFGTLS VFDRDLTPII
DRTHNKYVGT LLNIDPWVKE TFDIKGTFSE KKAAQGGIRE TVHDYHLVLK RNLYVTENRT
LQLDYLVNDT TYPGLEGTVL LHFNVTILPV HIFFSNITHT FPLTRRASSY AQVGKVCVEN
CRQFDGFRIA YRLELPDKNV SADVLSCHSA VSIAQAPDEM WGLLYVNDTE ELRRPECQDL
QYLVVVKEQH TQMETSVQIQ IILDNEVGQE SQPLLSCAEN RRRGDCESAR GLGTTTGRCQ
WRQGSDKGIS KNYSTCSPDL RTCPDSVCDA VESKDASICP QDCTKKTVIG GHEPGLRNGI
QAGHGTCYCY SEKCFCEKED IDETMCDDMC KTIIATALLL SFIVSILLSS YFIHRYHKNS
PKPPIASAEM TFRRPAQAYP ISFPANNLRR GSQESIETDT FKIPEDPKWE FPRKNLVLGK
TLGEGEFGKV VKATAFRLKG KAGYTTVAVK MLKENASHSG LRSLLSEFTL LKQVNHPHVI
KMYGACSQDG PLYLIVEYAK YGSLRNFLRE SRKVGPSYMG RDANRNSSYL ENPDDRALTM
GDLISFAWQI SRGMQYLAEM KLVHRDLAAR NVLVAEGRKM KISDFGLSRD VYEEDSYVKR
SKGRIPVKWM AIESLFDHIY TTQSDVWSFG VLLWEIVMLG GNPYPGIAPE RLFNLLKTGY
RMERPENCSE EMYNLMLRCW KQEADKRPTF SDISKELEKM MVKSRDYLDL AASTPADALL
YDDALSEEDT PLVDCNNAPL PRTLPSTWIE NKLYGMSYPN WPEKSPVPLS RHDATNPVFT
RYANDSVYAN WMALPSPAKA VDKVDS
//
