ID WDR46_MOUSE Reviewed; 622 AA.
AC Q9Z0H1;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 24-JAN-2024, entry version 156.
DE RecName: Full=WD repeat-containing protein 46;
DE AltName: Full=WD repeat-containing protein BING4;
GN Name=Wdr46; Synonyms=Bing4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129/SvJ;
RA Rowen L., Qin S., Madan A., Loretz C., Hall J., James R., Dors M.,
RA Shaffer T., Abbasi N., Ratcliffe A., Dickhoff R., Lasky S., Hood L.;
RT "Sequence of the mouse major histocompatibility complex class II region.";
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Scaffold component of the nucleolar structure. Required for
CC localization of DDX21 and NCL to the granular compartment of the
CC nucleolus. Part of the small subunit (SSU) processome, first precursor
CC of the small eukaryotic ribosomal subunit. During the assembly of the
CC SSU processome in the nucleolus, many ribosome biogenesis factors, an
CC RNA chaperone and ribosomal proteins associate with the nascent pre-
CC rRNA and work in concert to generate RNA folding, modifications,
CC rearrangements and cleavage as well as targeted degradation of pre-
CC ribosomal RNA by the RNA exosome. {ECO:0000250|UniProtKB:O15213}.
CC -!- SUBUNIT: Part of the small subunit (SSU) processome, composed of more
CC than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
CC Interacts with DDX21, NCL, NOP2 and EBNA1BP2.
CC {ECO:0000250|UniProtKB:O15213}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:O15213}.
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DR EMBL; AF110520; AAC97976.1; -; Genomic_DNA.
DR EMBL; AF100956; AAC69896.1; -; Genomic_DNA.
DR EMBL; BC046977; AAH46977.1; -; mRNA.
DR CCDS; CCDS28637.1; -.
DR RefSeq; NP_065628.1; NM_020603.2.
DR AlphaFoldDB; Q9Z0H1; -.
DR SMR; Q9Z0H1; -.
DR BioGRID; 208253; 3.
DR IntAct; Q9Z0H1; 1.
DR MINT; Q9Z0H1; -.
DR STRING; 10090.ENSMUSP00000025170; -.
DR GlyGen; Q9Z0H1; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9Z0H1; -.
DR PhosphoSitePlus; Q9Z0H1; -.
DR SwissPalm; Q9Z0H1; -.
DR EPD; Q9Z0H1; -.
DR jPOST; Q9Z0H1; -.
DR MaxQB; Q9Z0H1; -.
DR PaxDb; 10090-ENSMUSP00000025170; -.
DR PeptideAtlas; Q9Z0H1; -.
DR ProteomicsDB; 299971; -.
DR Pumba; Q9Z0H1; -.
DR Antibodypedia; 29045; 61 antibodies from 19 providers.
DR Ensembl; ENSMUST00000025170.11; ENSMUSP00000025170.10; ENSMUSG00000024312.11.
DR GeneID; 57315; -.
DR KEGG; mmu:57315; -.
DR UCSC; uc008cai.1; mouse.
DR AGR; MGI:1931871; -.
DR CTD; 9277; -.
DR MGI; MGI:1931871; Wdr46.
DR VEuPathDB; HostDB:ENSMUSG00000024312; -.
DR eggNOG; KOG1272; Eukaryota.
DR GeneTree; ENSGT00390000007075; -.
DR HOGENOM; CLU_022996_2_0_1; -.
DR InParanoid; Q9Z0H1; -.
DR OMA; KYTFIYD; -.
DR OrthoDB; 125824at2759; -.
DR PhylomeDB; Q9Z0H1; -.
DR TreeFam; TF300861; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 57315; 26 hits in 82 CRISPR screens.
DR ChiTaRS; Wdr46; mouse.
DR PRO; PR:Q9Z0H1; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9Z0H1; Protein.
DR Bgee; ENSMUSG00000024312; Expressed in gonadal ridge and 245 other cell types or tissues.
DR ExpressionAtlas; Q9Z0H1; baseline and differential.
DR Genevisible; Q9Z0H1; MM.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0032040; C:small-subunit processome; ISS:UniProtKB.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR012952; BING4_C_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR040315; WDR46/Utp7.
DR PANTHER; PTHR14085:SF3; WD REPEAT-CONTAINING PROTEIN 46; 1.
DR PANTHER; PTHR14085; WD-REPEAT PROTEIN BING4; 1.
DR Pfam; PF08149; BING4CT; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM01033; BING4CT; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..622
FT /note="WD repeat-containing protein 46"
FT /id="PRO_0000051396"
FT REPEAT 192..233
FT /note="WD 1"
FT REPEAT 234..271
FT /note="WD 2"
FT REPEAT 314..353
FT /note="WD 3"
FT REPEAT 356..395
FT /note="WD 4"
FT REPEAT 398..435
FT /note="WD 5"
FT REGION 1..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..588
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..622
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 41
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O15213"
SQ SEQUENCE 622 AA; 69048 MW; B1BF9A36AC612612 CRC64;
METAPKPGRG VPPKRDKPQA KRKKPRRYWE EETTPAAVAT SPGPPRKKAR TGESRPPRSK
SAHIAQKSRF SKKPPISKTA PDWKKPQRTL SGAQDPFPGP VPAPLEEARK FCRIDKSKTL
PHSKPKTQSK LEKAEAQEEE ASVRAARAEL LLAEEPGFLV GEDGEDTAKI LQTDIVEAVD
IASAAKHFDL NLRQFGPYRL NYSRTGRHLA LGGRRGHVAA LDWVTKKLMC EINVMEAVRD
IHFLHSEALL AVAQNRWLYI YDNQGIELHC IRRCDRVTRL EFLPFHFLLA TTSETGFLTY
LDVSVGKIVT ALNVRAGRLS VMAQNPYNAV IHLGHSNGTV SLWSPAVKEP LAKILCHRGG
VRAVAVDSTG TYMATSGLDH QLKIFDLRGT FQPLSSRTLP QGAGHLAFSQ RGLLVAGMGD
VVNIWAGQGK ASPPSLEQPY LTHRLSGHVH GLQFCPFEDV LGVGHSGGFT SMLVPGAAEP
NFDGLENNPY RSRKQRQEWE VKALLEKVPA ELICLNPRAL AEVDVVTLEQ QKKERIERLG
YDPDAKAAFQ PKAKQKGRSS TASLVKRKKK VMDQEHRDKV RQSLEQQQQK KKQDMAMPPG
ARPSALDRFV RRAREGGLQV DP
//
