ID Q9Z1I2_RAT Unreviewed; 265 AA.
AC Q9Z1I2;
DT 01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1999, sequence version 1.
DT 27-MAR-2024, entry version 127.
DE SubName: Full=p90 S6 kinase {ECO:0000313|EMBL:BAA74948.1};
DE Flags: Fragment;
GN Name=rsk {ECO:0000313|EMBL:BAA74948.1};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|EMBL:BAA74948.1};
RN [1] {ECO:0000313|EMBL:BAA74948.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Spraque-Dawley {ECO:0000313|EMBL:BAA74948.1};
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:BAA74948.1};
RX PubMed=9920808; DOI=10.1006/bbrc.1998.9940;
RA Kim Y.-B., Inoue T., Nakajima R., Shirai-Morishita Y., Tokuyama K.,
RA Suzuki M.;
RT "Effect of long-term exercise on gene expression of insulin signaling
RT pathway intermediates in skeletal muscle.";
RL Biochem. Biophys. Res. Commun. 254:720-727(1999).
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DR EMBL; D83013; BAA74948.1; -; mRNA.
DR IntAct; Q9Z1I2; 1.
DR MINT; Q9Z1I2; -.
DR PhylomeDB; Q9Z1I2; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR017892; Pkinase_C.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24347:SF197; CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1; 1.
DR PANTHER; PTHR24347; SERINE/THREONINE-PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00433; Pkinase_C; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:BAA74948.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT DOMAIN 1..68
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT DOMAIN 95..265
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 18..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 124
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAA74948.1"
FT NON_TER 265
FT /evidence="ECO:0000313|EMBL:BAA74948.1"
SQ SEQUENCE 265 AA; 30242 MW; B9ED252787517B47 CRC64;
IDWNKLYRKE IKPPFKPAVG RPEDTLHFDP EFTARTPTDS PGVPPSANAH HLFRGFSFVA
SSLVQEPSQQ DVPKAPIHPI VQQLHGNNIH FTDGYEIKED IGVGSYSVCK RCVHKATDAE
YAVKIIDKSK RDPSEEIEIL LRYGQHPNII TLKDVYDDGK YVYLVMELMR GGELXDRILR
QRCFSEREAS DVLYTIARTM DYLHSQGVVH RDLRPSNILY MDEXGNPESI RICDFGFAKQ
LRAENGLLMT PCYTANFVAP EVLKR
//
