ID Q9ZBK1_STRCO Unreviewed; 447 AA.
AC Q9ZBK1;
DT 01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1999, sequence version 1.
DT 27-MAR-2024, entry version 134.
DE SubName: Full=Crotonyl CoA reductase {ECO:0000313|EMBL:CAA22721.1};
GN OrderedLocusNames=SCO6473 {ECO:0000313|EMBL:CAA22721.1};
GN ORFNames=SC9C7.09c {ECO:0000313|EMBL:CAA22721.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAA22721.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAA22721.1, ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145
RC {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
RN [2] {ECO:0007829|PDB:3KRT}
RP X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 2-446.
RA Malashkevich V.N., Patskovsky Y., Toro R., Sauder J.M., Burley S.K.,
RA Almo S.C.;
RT "CRYSTAL STRUCTURE OF putative crotonyl CoA reductase from Streptomyces
RT coelicolor A3(2).";
RL Submitted (NOV-2009) to the PDB data bank.
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DR EMBL; AL939127; CAA22721.1; -; Genomic_DNA.
DR PIR; T35960; T35960.
DR RefSeq; NP_630556.1; NC_003888.3.
DR PDB; 3KRT; X-ray; 2.19 A; A/B/C/D=2-446.
DR PDBsum; 3KRT; -.
DR AlphaFoldDB; Q9ZBK1; -.
DR SMR; Q9ZBK1; -.
DR STRING; 100226.gene:17764130; -.
DR PaxDb; 100226-SCO6473; -.
DR DNASU; 1101912; -.
DR PATRIC; fig|100226.15.peg.6573; -.
DR eggNOG; COG0604; Bacteria.
DR HOGENOM; CLU_026673_5_0_11; -.
DR InParanoid; Q9ZBK1; -.
DR OrthoDB; 9790818at2; -.
DR PhylomeDB; Q9ZBK1; -.
DR EvolutionaryTrace; Q9ZBK1; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0043880; F:crotonyl-CoA reductase activity; IEA:InterPro.
DR CDD; cd08246; crotonyl_coA_red; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 2.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR010085; Crot_CoA_red.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR NCBIfam; TIGR01751; crot-CoA-red; 1.
DR PANTHER; PTHR44154; QUINONE OXIDOREDUCTASE; 1.
DR PANTHER; PTHR44154:SF1; QUINONE OXIDOREDUCTASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3KRT};
KW Reference proteome {ECO:0000313|Proteomes:UP000001973}.
FT DOMAIN 51..417
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 447 AA; 49279 MW; 435E5894797E93C1 CRC64;
MTVKDILDAI QSPDSTPADI AALPLPESYR AITVHKDETE MFAGLETRDK DPRKSIHLDD
VPVPELGPGE ALVAVMASSV NYNSVWTSIF EPLSTFGFLE RYGRVSDLAK RHDLPYHVIG
SDLAGVVLRT GPGVNAWQAG DEVVAHCLSV ELESSDGHND TMLDPEQRIW GFETNFGGLA
EIALVKSNQL MPKPDHLSWE EAAAPGLVNS TAYRQLVSRN GAGMKQGDNV LIWGASGGLG
SYATQFALAG GANPICVVSS PQKAEICRAM GAEAIIDRNA EGYRFWKDEN TQDPKEWKRF
GKRIRELTGG EDIDIVFEHP GRETFGASVF VTRKGGTITT CASTSGYMHE YDNRYLWMSL
KRIIGSHFAN YREAWEANRL IAKGRIHPTL SKVYSLEDTG QAAYDVHRNL HQGKVGVLCL
APEEGLGVRD REKRAQHLDA INRFRNI
//
