ID Q9ZFC9_9LACT Unreviewed; 333 AA.
AC Q9ZFC9;
DT 01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1999, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=Catabolite control protein A {ECO:0000256|ARBA:ARBA00019435, ECO:0000256|RuleBase:RU368079};
GN Name=ccpA {ECO:0000313|EMBL:AAC96330.1};
OS Lactococcus lactis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=1358 {ECO:0000313|EMBL:AAC96330.1};
RN [1] {ECO:0000313|EMBL:AAC96330.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IL1403 {ECO:0000313|EMBL:AAC96330.1};
RA Aleksandrzak T., Kowalczyk M., Kok J., Bardowski J.;
RT "Dual role of CcpA protein in regulation of sugar metabolism in Lactococcus
RT lactis.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Global transcriptional regulator of carbon catabolite
CC repression (CCR) and carbon catabolite activation (CCA), which ensures
CC optimal energy usage under diverse conditions.
CC {ECO:0000256|RuleBase:RU368079}.
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DR EMBL; AF106673; AAC96330.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9ZFC9; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR CDD; cd01392; HTH_LacI; 1.
DR CDD; cd06298; PBP1_CcpA; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR006377; CcpA.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR046335; LacI/GalR-like_sensor.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR NCBIfam; TIGR01481; ccpA; 1.
DR PANTHER; PTHR30146:SF150; CATABOLITE CONTROL PROTEIN A; 1.
DR PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF13377; Peripla_BP_3; 1.
DR PRINTS; PR00036; HTHLACI.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|RuleBase:RU368079};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU368079};
KW Repressor {ECO:0000256|RuleBase:RU368079};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU368079};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU368079}.
FT DOMAIN 6..60
FT /note="HTH lacI-type"
FT /evidence="ECO:0000259|PROSITE:PS50932"
SQ SEQUENCE 333 AA; 36721 MW; 38DB6738AE7272DE CRC64;
MVESTTTIYD VARVAGVSMA TVSRVVNGNA NVKEKTRQKV LEAIAELDYR PNAVARGLAS
KRTTTVGVIL PTITSTYFAA ITRGVDDIAS MYKYNMILAN SDNDVEKEEK VLETFLSKQV
DGIVYMGSSL DEKIRTSLKN SRTPVVLVGT IDGDKEIPSV NIDYHLAAYQ STKKLIDSGN
KKIAYIMGSL KDVENTERMV GYQQALLEKA NIEFDENLVF EGNYSYEQGK ALAERLLERG
ATSAVVSHDT VAVGLLSAMM DKGVKVPEDF EIISGANSPI TQYTYPTLTS VNQPLYDLGA
VAMRLLTKLM LKEDVEQNQL VLDQEIFSRR STK
//
