ID R0L7Y8_ANAPL Unreviewed; 1099 AA.
AC R0L7Y8;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 22-FEB-2023, entry version 57.
DE SubName: Full=Ras-specific guanine nucleotide-releasing factor 2 {ECO:0000313|EMBL:EOB01734.1};
DE Flags: Fragment;
GN ORFNames=Anapl_15731 {ECO:0000313|EMBL:EOB01734.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOB01734.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
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DR EMBL; KB743051; EOB01734.1; -; Genomic_DNA.
DR AlphaFoldDB; R0L7Y8; -.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF187; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 2; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049}.
FT DOMAIN 1..38
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 148..334
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 375..493
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 540..657
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 916..1099
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 631..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 66..93
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 634..651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EOB01734.1"
FT NON_TER 1099
FT /evidence="ECO:0000313|EMBL:EOB01734.1"
SQ SEQUENCE 1099 AA; 125130 MW; 94D20CFF4148D291 CRC64;
QYYFTVLFGH EGQKPLELRC EDEVDGDEWV EAIHQASYSD ILIEREVLMQ KYIHLVQIVE
TEKIAANQLR HQLEDQDTEI ERLKSEIIAL NKTKERMRPY QGNQEDEDPD IKKIKKVQSF
MRGWLCRRKW KTIVQDYICS PHAESMRKRN QIVFNMVEAE SEYVHQLYVL VNCFLRPLRM
AASSKKPPIS HDDVSSIFLN SETIMFLHEI FHQGLKARIA NWPTLILADL FDILLPMLNI
YQEFVRNHQY SLQVLANCKQ NRDFDKLLKQ YEANPACEGR MLETFLTYPM FQIPRYIITL
HELLAHTPHE HVERKSLEFA KSKLEELSRV MHDEVSDTEN IRKNLAIERT IVEGCDILLD
TSQTFIRQGS LIQVPSVERG KLSKVRLGSL SLKKEGERQC FLFTKHFLIC TRSSGGKLHL
LKTGGVLSLI ECTLVEETDA ADDDSKSSGQ VFGHLDFKLV VEPTDAPSFT VVLLAPSRQE
KAAWTSDISQ CIDNIRCNGL MTIVFEENSK VTVPHMIKSD ARLHRDDIDI CFSKTLNSCK
VPQIRYASVE RLLERLTDLR FLSIDFLNTF LHTYRIFTTA AVVLEKLSDI YRRPFTSIPV
RSLELFFATN QNNRGEYLAD GKSPHLCRKF SSPPPLSLSR TSSPVRTRKL SLTSPLNSRI
GALDLTTSSV ASSPTSTYSP ATSPPPTGSK VPLDLSKGPS SPEQSPGSIE DSLENPRIDL
CNKLRRSIRR AVLESVSVDR TIPESTSAVD TTELSPCRSP STPRHLRYRQ SGGQSGVQTA
DNSHCAVSPA SAFAIATAAA GHGSPPGFNN SERMCDKEFI MFLIHRAATN RVLNVLRHWV
SKHSQDFELN NELKMNVLNL LEEVLRDPDL LPQERKATAN ILRALSQDDQ DDNHLKIEDI
IQMVKCPKPE CFETLSAMEL AEQITLLDHI VFRSIPYEEF LGQGWMKLDK NERTPYIMKT
SQHFNDMSNL VASQIMNYAD VSSRANSIEK WVAVADICRC MHNYNGVLEI TSALNRSAIY
RLKKTWAKVS KQAKALMDKL QKTVSSEGRF KNLRETLKNC NPPAVPYLGM YLTDLAFIEE
GTPNFTEEGL VNFSKMRMV
//
