ID R0MMH2_NOSB1 Unreviewed; 439 AA.
AC R0MMH2;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Serine/threonine-protein kinase/endoribonuclease IRE1 {ECO:0000313|EMBL:EOB14063.1};
GN Name=ERN1 {ECO:0000313|EMBL:EOB14063.1};
GN ORFNames=NBO_41g0038 {ECO:0000313|EMBL:EOB14063.1};
OS Nosema bombycis (strain CQ1 / CVCC 102059) (Microsporidian parasite)
OS (Pebrine of silkworm).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nosematidae; Nosema.
OX NCBI_TaxID=578461 {ECO:0000313|EMBL:EOB14063.1, ECO:0000313|Proteomes:UP000016927};
RN [1] {ECO:0000313|EMBL:EOB14063.1, ECO:0000313|Proteomes:UP000016927}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CQ1 / CVCC 102059 {ECO:0000313|Proteomes:UP000016927};
RX PubMed=23496955; DOI=10.1186/1471-2164-14-186;
RA Pan G., Xu J., Li T., Xia Q., Liu S.L., Zhang G., Li S., Li C., Liu H.,
RA Yang L., Liu T., Zhang X., Wu Z., Fan W., Dang X., Xiang H., Tao M., Li Y.,
RA Hu J., Li Z., Lin L., Luo J., Geng L., Wang L., Long M., Wan Y., He N.,
RA Zhang Z., Lu C., Keeling P.J., Wang J., Xiang Z., Zhou Z.;
RT "Comparative genomics of parasitic silkworm microsporidia reveal an
RT association between genome expansion and host adaptation.";
RL BMC Genomics 14:186-186(2013).
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DR EMBL; KB908949; EOB14063.1; -; Genomic_DNA.
DR AlphaFoldDB; R0MMH2; -.
DR STRING; 578461.R0MMH2; -.
DR EnsemblFungi; EOB14063; EOB14063; NBO_41g0038.
DR VEuPathDB; MicrosporidiaDB:NBO_41g0038; -.
DR HOGENOM; CLU_624192_0_0_1; -.
DR OMA; LLIVCYN; -.
DR Proteomes; UP000016927; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF6; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51392; KEN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000313|EMBL:EOB14063.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000016927};
KW Transferase {ECO:0000313|EMBL:EOB14063.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 306..439
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
SQ SEQUENCE 439 AA; 52529 MW; 50EB5C3390A6CE8F CRC64;
MNRLYFYSGL EVYYPKEYGT SFTFLYLILL ILIIFIFLIK RKSVKIVLEL EKNESYTLYE
GLYMHKRVLI KWYKKRKPEI TKEIQILQEV HNNLYISRLV YYEDNYFNTF LVFEYLEEIN
SKLTKAMLHQ IVLAVKFLNE KNIFLKNFNP KNIRIQNGHT VLFNVGVHGD NKGWYSECQE
DDKIKNVFFL GCLLHYFITG YHPYDKRGLE KDCQSDEQSD LDNCDNRKDK DSCDNVKKDK
DKCEYKVNDL NNHDNNISNL TFLDHKSIQD NILLKKYKIR IEDPLVHDLI YHTIKAKIPE
RTSLQRLSAH PFFWDDSSKF EFIARYSDIL EGNPIQVKKI ERNKTRIFTK PWNSYLCSLV
SEELSVFRLY NFNSARDLIR VIRNKGRHYN QIPGNVKEVY RTFPGGFMSY WCGLFPGLLI
VCYNCGYQLR TNELLEKFY
//
