ID R1CGH7_EMIHU Unreviewed; 1179 AA.
AC R1CGH7;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
GN ORFNames=EMIHUDRAFT_469732 {ECO:0000313|EMBL:EOD21888.1};
OS Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi).
OC Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Isochrysidales;
OC Noelaerhabdaceae; Emiliania.
OX NCBI_TaxID=2903 {ECO:0000313|EMBL:EOD21888.1};
RN [1] {ECO:0000313|EMBL:EOD21888.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|EMBL:EOD21888.1};
RG DOE Joint Genome Institute;
RA Read B., Kegel J., Klute M., Kuo A., Lefebvre S.C., Maumus F., Mayer C.,
RA Miller J., Allen A., Bidle K., Borodovsky M., Bowler C., Brownlee C.,
RA Claverie J.-M., Cock M., De Vargas C., Elias M., Frickenhaus S.,
RA Gladyshev V.N., Gonzalez K., Guda C., Hadaegh A., Herman E.,
RA Iglesias-Rodriguez D., Jones B., Lawson T., Leese F., Lin Y.-C.,
RA Lindquist E., Lobanov A., Lucas S., Malik S.-H.B., Marsh M.E., Mock T.,
RA Monier A., Moreau H., Mueller-Roeber B., Napier J., Ogata H., Parker M.,
RA Probert I., Quesneville H., Raines C., Rensing S., Riano-Pachon D.M.,
RA Richier S., Rokitta S., Salamov A., Sarno A.F., Schmutz J., Schroeder D.,
RA Shiraiwa Y., Soanes D.M., Valentin K., Van Der Giezen M., Van Der Peer Y.,
RA Vardi A., Verret F., Von Dassow P., Wheeler G., Williams B., Wilson W.,
RA Wolfe G., Wurch L.L., Young J., Dacks J.B., Delwiche C.F., Dyhrman S.,
RA Glockner G., John U., Richards T., Worden A.Z., Zhang X., Grigoriev I.V.;
RT "Genome variability drives Emilianias global distribution.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000013827}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP1516 {ECO:0000313|Proteomes:UP000013827};
RX PubMed=23760476; DOI=10.1038/nature12221;
RA Read B.A., Kegel J., Klute M.J., Kuo A., Lefebvre S.C., Maumus F.,
RA Mayer C., Miller J., Monier A., Salamov A., Young J., Aguilar M.,
RA Claverie J.M., Frickenhaus S., Gonzalez K., Herman E.K., Lin Y.C.,
RA Napier J., Ogata H., Sarno A.F., Shmutz J., Schroeder D., de Vargas C.,
RA Verret F., von Dassow P., Valentin K., Van de Peer Y., Wheeler G.,
RA Dacks J.B., Delwiche C.F., Dyhrman S.T., Glockner G., John U., Richards T.,
RA Worden A.Z., Zhang X., Grigoriev I.V., Allen A.E., Bidle K., Borodovsky M.,
RA Bowler C., Brownlee C., Cock J.M., Elias M., Gladyshev V.N., Groth M.,
RA Guda C., Hadaegh A., Iglesias-Rodriguez M.D., Jenkins J., Jones B.M.,
RA Lawson T., Leese F., Lindquist E., Lobanov A., Lomsadze A., Malik S.B.,
RA Marsh M.E., Mackinder L., Mock T., Mueller-Roeber B., Pagarete A.,
RA Parker M., Probert I., Quesneville H., Raines C., Rensing S.A.,
RA Riano-Pachon D.M., Richier S., Rokitta S., Shiraiwa Y., Soanes D.M.,
RA van der Giezen M., Wahlund T.M., Williams B., Wilson W., Wolfe G.,
RA Wurch L.L.;
RT "Pan genome of the phytoplankton Emiliania underpins its global
RT distribution.";
RL Nature 499:209-213(2013).
RN [3] {ECO:0000313|EnsemblProtists:EOD21888}
RP IDENTIFICATION.
RG EnsemblProtists;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; KB865803; EOD21888.1; -; Genomic_DNA.
DR RefSeq; XP_005774317.1; XM_005774260.1.
DR STRING; 2903.R1CGH7; -.
DR PaxDb; 2903-EOD21888; -.
DR EnsemblProtists; EOD21888; EOD21888; EMIHUDRAFT_469732.
DR GeneID; 17267433; -.
DR KEGG; ehx:EMIHUDRAFT_469732; -.
DR eggNOG; KOG1778; Eukaryota.
DR HOGENOM; CLU_273251_0_0_1; -.
DR OMA; CAPKHER; -.
DR Proteomes; UP000013827; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15517; PHD_TCF19_like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR031162; CBP_P300_HAT.
DR InterPro; IPR013178; Histone_AcTrfase_Rtt109/CBP.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13808; CBP/P300-RELATED; 1.
DR PANTHER; PTHR13808:SF1; HISTONE ACETYLTRANSFERASE; 1.
DR Pfam; PF08214; HAT_KAT11; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM01250; KAT11; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR PROSITE; PS51727; CBP_P300_HAT; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000013827};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 779..1113
FT /note="CBP/p300-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51727"
FT DOMAIN 1112..1166
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 92..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..162
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1179 AA; 130343 MW; 00DEDEA99B995D43 CRC64;
MGRKSVFSKR SRFGGSDLIT RIPRSDRSSS QTRHFTFFLS RYTGGGSRLD GPLAGAAQPA
REPLQLELRS VAGRDALRQA LLAMVPQIDE LQKKRELMKR SGPPPQRPTP MGMPQQGQLP
PGTVQPLAQP TTVQGHVLPN QPGPPPLPQP PPPIPKPVIG PVPPQRSHSQ VGLAESAVSG
SAMLEPKMGL PPVAHPPEYK PNLGQHGGQH GMGGVNQNRK STLPVQALVH AFHCNEAGCK
QKSCVETKQV PSGGHPGATG AAAPRRMSVP SPPDGRVSGG APRLGGVHSN NEAVRQKLRQ
LDPAQVKRML LQHVRSCQNK QCHTCHKLRE RIKASRANNT GGGGSSHDPL QRPFGGGGIP
PLQRPGSIGG MTAGGMEGSS NILMGGGFGG GGGFGGFPGL DGGPGLLGAG TGVGFGLQGS
SPWVPSAQSG LQRKTKVKQR GRENIQPGLA WSSRQGDQRT ALAEGTRFSR IRLKLKGVAP
TLAPSRSRDR KKKARADDDD GGRGEKADIK RLRRQISQKS TQDEEEEMAQ AGMDQYRVAP
GRPASLELNK FEVGSWVEHR EDASTWRLAI VRSQQQAGGQ LQYTIQLEPV EQNRHKQTGV
PHADLRMACS HPECKKHALH LAALPLFCDR CRKALMSTPQ QRVYFQEKEA VESGQSLRLC
STCVGSLRAE LKSKGQAGLD AEVQKFTRDL PQGADRQSLV LETLEETALP QRAENSDAPI
LSTDIDTRWA QCAGCFKWWH WVCAMYVETQ YKNGRPFYCR GCAPKHERLS DELQSLLENN
DATKLTQIPM GEFIEEQVRS DLEEAKIDCT PITIRIVSSL LMNSYTPERL VEHQQALGES
YPREFPYKSK ALLAFQKRDG LDVCLFALYV QEYGSDCPEP NKNRVYISYL DSVRYFESEP
MGHRSTVYHS ILVAYLQWTR MLGFKYVHIW VEPPKSGDEY IFFARSDQQR KPMKREKLRE
WYKGMLDKAK AKNVVEHYGT MHDMFNGLKS LAEIPLFHGD QWEITVPSLL GLDDEEYVSA
PKSNKLVRMD SKDVVQKAQQ EMQHLKRHFL VAVLRDPDLS PMKDNDPVIS TDLTDSRQTF
LGQCQMCHWQ FNTLRHAQYS TRMILNHIHN KPSYCVEDCQ RGRVEDGSFM VGCDVCDNWY
HGDCVGISKD EANTMDSYLC ARCRALDESG GLDEGGGGS
//
