ID R2M8U5_ENTFC Unreviewed; 787 AA.
AC R2M8U5;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Probable phosphoketolase {ECO:0000256|HAMAP-Rule:MF_01403};
DE EC=4.1.2.- {ECO:0000256|HAMAP-Rule:MF_01403};
GN ORFNames=UA3_01191 {ECO:0000313|EMBL:EOH56007.1};
OS Enterococcus faecium EnGen0263.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1158553 {ECO:0000313|EMBL:EOH56007.1, ECO:0000313|Proteomes:UP000013667};
RN [1] {ECO:0000313|EMBL:EOH56007.1, ECO:0000313|Proteomes:UP000013667}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAA1280 {ECO:0000313|EMBL:EOH56007.1,
RC ECO:0000313|Proteomes:UP000013667};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Gilmore M.S., Lebreton F., Courvalin P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterococcus faecium UAA1280.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964,
CC ECO:0000256|HAMAP-Rule:MF_01403};
CC -!- SIMILARITY: Belongs to the XFP family. {ECO:0000256|ARBA:ARBA00005623,
CC ECO:0000256|HAMAP-Rule:MF_01403}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOH56007.1}.
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DR EMBL; AJAD01000011; EOH56007.1; -; Genomic_DNA.
DR RefSeq; WP_010732413.1; NZ_KB946086.1.
DR AlphaFoldDB; R2M8U5; -.
DR PATRIC; fig|1158553.3.peg.1211; -.
DR HOGENOM; CLU_013954_2_0_9; -.
DR Proteomes; UP000013667; Unassembled WGS sequence.
DR GO; GO:0016832; F:aldehyde-lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR HAMAP; MF_01403; Phosphoketolase; 1.
DR InterPro; IPR023962; Phosphoketolase.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005593; Xul5P/Fru6P_PKetolase.
DR InterPro; IPR018969; Xul5P/Fru6P_PKetolase_C.
DR InterPro; IPR019790; Xul5P/Fru6P_PKetolase_CS.
DR InterPro; IPR018970; Xul5P/Fru6P_PKetolase_N.
DR InterPro; IPR019789; Xul5P/Fru6P_PKetolase_ThDP_BS.
DR PANTHER; PTHR31273; PHOSPHOKETOLASE-RELATED; 1.
DR PANTHER; PTHR31273:SF0; PHOSPHOKETOLASE-RELATED; 1.
DR Pfam; PF03894; XFP; 1.
DR Pfam; PF09363; XFP_C; 1.
DR Pfam; PF09364; XFP_N; 1.
DR PIRSF; PIRSF017245; Phosphoketolase; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS60002; PHOSPHOKETOLASE_1; 1.
DR PROSITE; PS60003; PHOSPHOKETOLASE_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_01403};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052, ECO:0000256|HAMAP-
KW Rule:MF_01403}.
FT DOMAIN 5..367
FT /note="Xylulose 5-phosphate/Fructose 6-phosphate
FT phosphoketolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF09364"
FT DOMAIN 584..782
FT /note="Xylulose 5-phosphate/Fructose 6-phosphate
FT phosphoketolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09363"
SQ SEQUENCE 787 AA; 89780 MW; 48EB3B3578DAC912 CRC64;
MDYSSKEYFD KMTAWWRAAN YLSVGQIYLK DNPLLRRTLK PEDVKKHPIG HWGTIPGQNF
IYVHLNRVIN KYDLNMFYIE GPGHGGQVMV SNAYLDGSYT EIYPEVTEDE TGMQKLFKRF
SFPGGIASHA APETPGSIHE GGELGYSLSH GVGAVLDNPE VISAVVIGDG EAETGPLAGS
WFSNVFINPV KDGAVLPILH LNGAKIANPT ILARKSDEEL ANYFNGLGWE PFFIEGNDPE
KLNPVMAEKM DQAIEKIKSI QKEARLKTAT DVVMPKWPVL IVRTPKGWTG LEEWDGKPIE
GTFRAHQVPI PVDQEHMDHA DDLLRWLKSY EPEKLFDAQG RILEEIREIA PTGDQRMAKN
PITNGGIDPK PLVMPDWKKY TLQFEQPGSV KAEDMTELGK FVREIIEENP ENFRIFGPDE
TKSNRLNQVF KTTNRQWMEK IELENDEWLS PSGRVIDSQL SEHQDEGFLE GYVLTGRHGF
FASYESFLRV VDSMLTQHFK WMRKSHDLSW RNDYPSLNLI ASSTVFQQDH NGYSHQDPGI
LTHLAEKKAE FIREYLPADA NTLLAVMDKA FRSSEKINLI ISSKHPRAQF YSAEEAAVLV
NEGLKIIDWA STAKEEEPEL VIAAAGTESN LEALAAVTLL LEEFPKLKIR FINIVDLLKL
RHPSQDPRGL SDEEFDQYFT KDKPILFAFH GYETLVRTIF FDRHNHHLMI HGYKENGDIT
TPFDMRVVNE LDRYHLAKDA ALKIKGSQAE DFAKKMDQRL QEHQNYIREN GIDLPEVLDW
KWKNLGQ
//
