ID R2M9W5_ENTFC Unreviewed; 547 AA.
AC R2M9W5;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=UA3_01702 {ECO:0000313|EMBL:EOH55373.1};
OS Enterococcus faecium EnGen0263.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1158553 {ECO:0000313|EMBL:EOH55373.1, ECO:0000313|Proteomes:UP000013667};
RN [1] {ECO:0000313|EMBL:EOH55373.1, ECO:0000313|Proteomes:UP000013667}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAA1280 {ECO:0000313|EMBL:EOH55373.1,
RC ECO:0000313|Proteomes:UP000013667};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Gilmore M.S., Lebreton F., Courvalin P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterococcus faecium UAA1280.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOH55373.1}.
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DR EMBL; AJAD01000012; EOH55373.1; -; Genomic_DNA.
DR RefSeq; WP_010732734.1; NZ_KB946086.1.
DR AlphaFoldDB; R2M9W5; -.
DR PATRIC; fig|1158553.3.peg.1729; -.
DR HOGENOM; CLU_020211_11_2_9; -.
DR Proteomes; UP000013667; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR033463; sCache_3.
DR InterPro; IPR029151; Sensor-like_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR016120; Sig_transdc_His_kin_SpoOB.
DR InterPro; IPR039506; SPOB_a.
DR PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF17203; sCache_3_2; 1.
DR Pfam; PF14689; SPOB_a; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR SUPFAM; SSF55890; Sporulation response regulatory protein Spo0B; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EOH55373.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 341..537
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 547 AA; 61260 MW; 6BD85980790D543E CRC64;
MFPFLKKKPL KLQNTIILVV CFSTFVSLIV SAILIRNFIL SMNRSSVSDR ISSIAKIVAS
DKLIQKKLQT GDPTHVIQGI TNEIMVASNL DFIVVMDPEG IRYSHADPSY IGLPFSSHED
VKKVIGGQEF FSEKEGMLGF GFRYFVPIYY DQEIIGAVCV GLTNNTIDNQ VKDGQKMIVF
SLIIGLSVGI IGAVFLAQKM KKVLLGLEPQ EIAEQLSEKT IIENEVDEGI LAISSDKTIL
LINTPAKNIF YQIKRLSDFE VGKKISDNLY DVLFKETIEH QTTVRTQSMY LNGIETISSV
TPLFSNDRFL GAVATLRNRS EVMKLMEELG GTKQYINSMR AQTHEFMNKL HVISGLIDLK
KYEEVTHFIQ QLNQNYKKEI GQVSNLIKVP AIAGFLLGKI NEAKEQSVEM LLESDSFIPK
MEMDDSIHSL LQVLGNLLDN AKEAVLQMPE RNGQVRLHLN YDTEAEVFIV TVCDDGVGIS
EEISEKIFTL GFSTKGINRG YGLNIIHSIV KRHGGILEFS KQTNGGTIVY LELPKKEDQN
DDKCPNN
//
