ID R2PAP1_ENTFC Unreviewed; 225 AA.
AC R2PAP1;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN ORFNames=UA3_01364 {ECO:0000313|EMBL:EOH56180.1};
OS Enterococcus faecium EnGen0263.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1158553 {ECO:0000313|EMBL:EOH56180.1, ECO:0000313|Proteomes:UP000013667};
RN [1] {ECO:0000313|EMBL:EOH56180.1, ECO:0000313|Proteomes:UP000013667}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAA1280 {ECO:0000313|EMBL:EOH56180.1,
RC ECO:0000313|Proteomes:UP000013667};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Gilmore M.S., Lebreton F., Courvalin P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterococcus faecium UAA1280.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOH56180.1}.
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DR EMBL; AJAD01000011; EOH56180.1; -; Genomic_DNA.
DR RefSeq; WP_010732525.1; NZ_KB946086.1.
DR AlphaFoldDB; R2PAP1; -.
DR PATRIC; fig|1158553.3.peg.1384; -.
DR HOGENOM; CLU_070319_1_0_9; -.
DR Proteomes; UP000013667; Unassembled WGS sequence.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 4: Predicted;
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT DOMAIN 84..222
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
SQ SEQUENCE 225 AA; 25551 MW; 26FAE07AC29A81BB CRC64;
MKKILIVETN VNQYKGTNKA TGLWLGETVE FLAETYKYQF EADFVSPLGG YVPIDPRSMK
NLDSDVMDIY SNKTFIEKGL RNTLSPANVK SEDYIAIYFT GGHGVMWDFP ENNALQKIAS
DIYESNGYVL SVCHGIAGLL NIRLANNDYL IANKKLTGFT KTEERLAMKS KIVPFDNEEM
TVSRKGHFIK KRFFKSHVVK DGHLITGQNP YSTRELARTF IKEVI
//
