ID R2XFR0_9ENTE Unreviewed; 866 AA.
AC R2XFR0;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Aldehyde-alcohol dehydrogenase {ECO:0000256|PIRNR:PIRNR000111};
GN ORFNames=UKC_03636 {ECO:0000313|EMBL:EOI53684.1};
OS Enterococcus gilvus ATCC BAA-350.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1158614 {ECO:0000313|EMBL:EOI53684.1, ECO:0000313|Proteomes:UP000013750};
RN [1] {ECO:0000313|EMBL:EOI53684.1, ECO:0000313|Proteomes:UP000013750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-350 {ECO:0000313|EMBL:EOI53684.1,
RC ECO:0000313|Proteomes:UP000013750};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Gilmore M.S., Lebreton F., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterococcus gilvus ATCC BAA-350.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SIMILARITY: In the C-terminal section; belongs to the iron-containing
CC alcohol dehydrogenase family. {ECO:0000256|ARBA:ARBA00035645,
CC ECO:0000256|PIRNR:PIRNR000111}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the aldehyde
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00035641,
CC ECO:0000256|PIRNR:PIRNR000111}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOI53684.1}.
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DR EMBL; AJDQ01000012; EOI53684.1; -; Genomic_DNA.
DR RefSeq; WP_010781976.1; NZ_KB946874.1.
DR AlphaFoldDB; R2XFR0; -.
DR PATRIC; fig|1158614.3.peg.3622; -.
DR eggNOG; COG1012; Bacteria.
DR eggNOG; COG1454; Bacteria.
DR HOGENOM; CLU_007207_1_0_9; -.
DR OrthoDB; 9815791at2; -.
DR Proteomes; UP000013750; Unassembled WGS sequence.
DR GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR GO; GO:0015976; P:carbon utilization; IEA:InterPro.
DR CDD; cd08178; AAD_C; 1.
DR CDD; cd07122; ALDH_F20_ACDH; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR034789; AAD_C.
DR InterPro; IPR001670; ADH_Fe/GldA.
DR InterPro; IPR018211; ADH_Fe_CS.
DR InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR012079; Bifunc_Ald-ADH.
DR PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR11496:SF83; HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00171; Aldedh; 1.
DR Pfam; PF00465; Fe-ADH; 1.
DR PIRSF; PIRSF000111; ALDH_ADH; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR PROSITE; PS00913; ADH_IRON_1; 1.
DR PROSITE; PS00060; ADH_IRON_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR000111}.
FT DOMAIN 17..406
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT DOMAIN 464..850
FT /note="Alcohol dehydrogenase iron-type/glycerol
FT dehydrogenase GldA"
FT /evidence="ECO:0000259|Pfam:PF00465"
SQ SEQUENCE 866 AA; 94151 MW; D93888D618BAAE11 CRC64;
MAKAIEKEKD AVSVEQVIDE LATKANVALK EMEDFDQEKI DHIVHEMAMA ALDKHMLLAK
MAVEETGRGV VEDKAIKNMY ASEYIWNSIK HDKTVGVIGE DKQKGLIEVA GPVGVVCGVT
PTTNPTSTTI FKSMIALKTG NPIVFAFHPS AQKCSAEAAR IVRDAAIAAG APENCIQWIE
KPSIDATSML MNHPGVAIVL ATGGPGMVKS AYSTGKPALG VGAGNVPSYI EKTAKIKRAV
NDLIVSKSFD NGMICASEQA VIVDKEVYEE VKAEFQAHQV YVVKKAELKR LEDAVMNEGK
YAVNPAIVGH SAEDIAQRAG IKVPAGTKIL IAELDGVGAD YPLSREKLSP VLAMIKANDH
VHGFDLCQGM LELGGLGHTA VIHTEDEDLQ VKFGLRMKAC RILVNSPSAE GGIGDIYNEM
IPSLTLGCGS YGKNSVSKNV SAINLINVKT IAKRRNNMQW FKLPPKIFFE KNSLLYLTKM
ENVERVMLVC DPGMVQFGYA DIVREVLGRR ENDVKVEVFS DVEPNPSTNT VYKGLEMFND
FQPDTVIALG GGSAMDAAKG MWMFFEHPDT SFFGAKQKFL DIRKRTYGIA KPEKAKLVCI
PTTSGTGAEV TPFAVITDSE THVKYPLADY ALTPDVAIVD PQFVMTVPAS VTADTGMDVL
THAIESYVSV MASDYTRGLS LQAIKLVFEN LEKSVKTADP EAREKMHNAS AMAGMAFANA
FLGICHSVAH KIGGEYGIPH GRTNAILLPH IIRYNAKDPQ KHAMFPKYDY FRADTDYADI
AKFLGLKGNT TAELVEALIE AVYNLGVTTG IDMNLKAQGV TQETLNTTVD RMAELAYEDQ
CTTANPKEPL ISELKEIIVT AYDYKA
//
