ID R3GZK7_ENTFL Unreviewed; 807 AA.
AC R3GZK7;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=DNA translocase FtsK {ECO:0000256|ARBA:ARBA00020887};
GN ORFNames=WOK_02175 {ECO:0000313|EMBL:EOJ98577.1};
OS Enterococcus faecalis EnGen0359.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1169307 {ECO:0000313|EMBL:EOJ98577.1, ECO:0000313|Proteomes:UP000013601};
RN [1] {ECO:0000313|EMBL:EOJ98577.1, ECO:0000313|Proteomes:UP000013601}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TR197 {ECO:0000313|EMBL:EOJ98577.1,
RC ECO:0000313|Proteomes:UP000013601};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Gilmore M.S., Lebreton F., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterococcus faecalis TR197.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA.
CC {ECO:0000256|ARBA:ARBA00025923}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOJ98577.1}.
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DR EMBL; ASDV01000011; EOJ98577.1; -; Genomic_DNA.
DR RefSeq; WP_010826565.1; NZ_KB944819.1.
DR AlphaFoldDB; R3GZK7; -.
DR PATRIC; fig|1169307.3.peg.2174; -.
DR HOGENOM; CLU_001981_9_6_9; -.
DR Proteomes; UP000013601; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000313|EMBL:EOJ98577.1};
KW Cell division {ECO:0000313|EMBL:EOJ98577.1};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 462..659
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 779..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..728
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 480..487
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 807 AA; 88949 MW; 31E0CA68C4336285 CRC64;
MAQKRATNKK KSTTKKKTKK QQQQQERLNY MFLGLIFILF GVFGLFRLGF LGTLLANCLR
LVVGNTFPFA AILLILYGLL VMIYGKDFPL KRGRPIFGAV LIYISVLLFF HAFMFRNVSG
SQPDILGNTW EFLQSDLKAN QVTQNVGGGM IGALLYQGTY FLVAQFGSYL IATLLLLAGI
FLMSMWDFQQ IVDHFQSIQD RLSHVSAKSQ ARQEEKEAKR AGKKEAKAAE RQAKIEAAAQ
QKLQERERME QAAAERLTKT PVETHQPMVE EPAAPTPVQI DSFQQQNQAM PVPPIAATKP
QREQEEEAAD EAGVLEFEIS EEAEDRDYQL PPTDLLDTIQ ATDQSGEYEK IEKNIGVLEQ
TFKSFGVDAK VVKASLGPSV TKFEVQPAVG VKVSKIVNLT DDIALALAAK DVRMEAPIPG
KSLIGIEVPN SAISTVSFRD IVEAQPSHPD KLLEVPLGRD ISGMVQTADL SKMPHLLIAG
STGSGKSVAI NGIITGILMQ AKPHEVKLMM IDPKMVELNV YNGIPHLLTP VVTNPRKAAQ
ALQKVVQEME FRYEKFAATG VRNITGYNQL IQQKNAEDGE NRPILPFIVV IVDELADLMM
VASNEVEDAI IRLAQMARAA GIHMILATQR PSVDVITGII KANVPSRMAF AVSSGTDSRT
IIDTNGAEKL LGRGDMLFLP MGENKPIRIQ GAFISDQEVE RVVAFVTDQQ EAEYQESMMP
TDEPTTSGGG EAPQDELFEE AKNLVVEMQT ASISLLQRRF RIGYNRAARL VDELEAHGVI
GPSEGSKPRK VFLQAESEEA APETPEQ
//
