ID R4Q4Q8_HELPX Unreviewed; 380 AA.
AC R4Q4Q8;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=alanine dehydrogenase {ECO:0000256|ARBA:ARBA00012897};
DE EC=1.4.1.1 {ECO:0000256|ARBA:ARBA00012897};
GN ORFNames=K750_00525 {ECO:0000313|EMBL:AGL69068.1};
OS Helicobacter pylori UM037.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1321939 {ECO:0000313|EMBL:AGL69068.1, ECO:0000313|Proteomes:UP000013898};
RN [1] {ECO:0000313|EMBL:AGL69068.1, ECO:0000313|Proteomes:UP000013898}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UM037 {ECO:0000313|EMBL:AGL69068.1,
RC ECO:0000313|Proteomes:UP000013898};
RA Khosravi Y., Rehvathy V., Amoyo A., Seow S., Ong J., Susana W., Primo B.,
RA Meredith A., Siddarth S., Pettersson S., Loke M., Goh K., Vadivelu J.;
RT "Draft Genome Sequences of Helicobacter pylori Strain UM037 and UM066 using
RT PacBio Sequencing Platform.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the AlaDH/PNT family.
CC {ECO:0000256|ARBA:ARBA00005689}.
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DR EMBL; CP005492; AGL69068.1; -; Genomic_DNA.
DR RefSeq; WP_015643545.1; NC_021217.3.
DR AlphaFoldDB; R4Q4Q8; -.
DR KEGG; hpyi:K750_00525; -.
DR PATRIC; fig|1321939.6.peg.114; -.
DR HOGENOM; CLU_003376_3_0_7; -.
DR Proteomes; UP000013898; Chromosome.
DR GO; GO:0000286; F:alanine dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0042853; P:L-alanine catabolic process; IEA:InterPro.
DR CDD; cd05305; L-AlaDH; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR008141; Ala_DH.
DR InterPro; IPR007886; AlaDH/PNT_N.
DR InterPro; IPR007698; AlaDH/PNT_NAD(H)-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42795; ALANINE DEHYDROGENASE; 1.
DR PANTHER; PTHR42795:SF1; ALANINE DEHYDROGENASE 1; 1.
DR Pfam; PF01262; AlaDh_PNT_C; 1.
DR Pfam; PF05222; AlaDh_PNT_N; 1.
DR SMART; SM01002; AlaDh_PNT_C; 1.
DR SMART; SM01003; AlaDh_PNT_N; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 4..135
FT /note="Alanine dehydrogenase/pyridine nucleotide
FT transhydrogenase N-terminal"
FT /evidence="ECO:0000259|SMART:SM01003"
FT DOMAIN 152..300
FT /note="Alanine dehydrogenase/pyridine nucleotide
FT transhydrogenase NAD(H)-binding"
FT /evidence="ECO:0000259|SMART:SM01002"
SQ SEQUENCE 380 AA; 40989 MW; 6F4E73422A1613BB CRC64;
MTIGLVKESM DLESRVALVP DDVALIVQKG VEVLVENSAG ANSGYSNEAY ESVGAKIVDS
KTAWGQDLVV KCKEPLEHEY HLLKEKATLF SYLDLAYQKS LCEMFIDKKI TSICTETIAG
PKNDYPILAP MSVVAGRLAA HLVQHYLLAL EHVKGFMGKG VMLGGLSGAQ RAKIVVVGGG
VVGMESAKVL SQMGAKVTIL ELDYAKLQNH PYYHLYDLEV LSVNEANIIQ ALNGAVGLVG
AVLVTASQTP KVILRRHLKC MQKQGVVIDV ACDLGGCIET IHQTSHSNPV YVEEDLLHYG
VPNMPGIAAK TSSVAYSHAS VPYLLYYLEH GLKGFLKANT KIVANTLGGL SAYNGYITQE
GIAKAFNLAF KSPLEVLKEL
//
