ID R4W836_9EURY Unreviewed; 433 AA.
AC R4W836;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Carboxypeptidase Q {ECO:0000256|ARBA:ARBA00014116};
DE AltName: Full=Plasma glutamate carboxypeptidase {ECO:0000256|ARBA:ARBA00033328};
GN ORFNames=L593_01605 {ECO:0000313|EMBL:AGN00274.1};
OS Salinarchaeum sp. Harcht-Bsk1.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Natronoarchaeaceae; Salinarchaeum.
OX NCBI_TaxID=1333523 {ECO:0000313|EMBL:AGN00274.1, ECO:0000313|Proteomes:UP000014072};
RN [1] {ECO:0000313|EMBL:AGN00274.1, ECO:0000313|Proteomes:UP000014072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Harcht-Bsk1 {ECO:0000313|EMBL:AGN00274.1};
RX PubMed=23868130;
RA Dominova I.N., Sorokin D.Y., Kublanov I.V., Patrushev M.V.,
RA Toshchakov S.V.;
RT "Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T,
RT Isolated from Hypersaline Lake Baskunchak, Russia.";
RL Genome Announc. 1:E00505-13(2013).
CC -!- SUBUNIT: Homodimer. The monomeric form is inactive while the homodimer
CC is active. {ECO:0000256|ARBA:ARBA00025833}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}.
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DR EMBL; CP005962; AGN00274.1; -; Genomic_DNA.
DR RefSeq; WP_020445168.1; NC_021313.1.
DR AlphaFoldDB; R4W836; -.
DR STRING; 1333523.L593_01605; -.
DR GeneID; 16179873; -.
DR KEGG; sali:L593_01605; -.
DR PATRIC; fig|1333523.5.peg.326; -.
DR eggNOG; arCOG02959; Archaea.
DR HOGENOM; CLU_033697_0_0_2; -.
DR OrthoDB; 18376at2157; -.
DR Proteomes; UP000014072; Chromosome.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0070573; F:metallodipeptidase activity; IEA:InterPro.
DR CDD; cd04819; PA_2; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR039866; CPQ.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR12053:SF3; CARBOXYPEPTIDASE Q; 1.
DR PANTHER; PTHR12053; PROTEASE FAMILY M28 PLASMA GLUTAMATE CARBOXYPEPTIDASE-RELATED; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022645};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Protease {ECO:0000256|ARBA:ARBA00022645};
KW Reference proteome {ECO:0000313|Proteomes:UP000014072}.
FT DOMAIN 91..184
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 208..392
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 433 AA; 47043 MW; 8EEE8F3B05A1A8E1 CRC64;
MTNWIGEAFT SDAGWNHLET LVDVGDRMAG SEGEREAAAA TRDALAEVGA RDAHLESFDV
QGWTRGTSEL RAGDTSQECI ALPRSPSGEA TGELIDVGYG LPSDFEQDLE GAVVMAASNV
PGWYDRFLHR REKYYHAVEA GAAAFVFRNH VEGCLAPTGS VGTEDDPIGD VPAIGVSKEV
GDRLLRRWEG DSVTVDVEAE ISDATSRNVH ATLGPDTDEE VLLTSHVDAH DIAEGAGDNG
AGTAVVVEAA KALAAREDEL DTKVHLLVYG AEEVGLCGSA YDSDQRDHDD IKAIVNSDGV
VRGRTLRCYT HDFDELEAAA ETVADRFDHP IETTPKLNPH SDHWPYVQWG VPGFHLMSET
DYEGRGWGHT RADTLDKLEQ RTLREQSILI ADLVDHLADS DTTIEHRTPE SIAAQLEDDD
LAEGMKVIGD WPY
//
